Patents by Inventor E. Hallinan

E. Hallinan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amidino compounds useful as nitric oxide synthase inhibitors
    Publication number: 20050165106
    Abstract: The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
    Type: Application
    Filed: January 10, 2005
    Publication date: July 28, 2005
    Applicant: Pharmacia Corporation
    Inventors: Ronald Webber, Richard Durley, Alok Awasthi, Arijia Bergmanis, Kam Fok, Scott Ganser, Timothy Hagen, E. Hallinan, Donald Hansen, Brian Hickory, Pamela Manning, Michael Mao, Alan Moormann, Barnett Pitzele, Michelle Promo, Richard Schartman, Jeffrey Scholten, Jeffrey Snyder, Mihaly Toth, Mahima Trivedi, Sofya Tsymbalov, Foe Tjoeng
  • Benzopyran compounds useful for treating inflammatory conditions
    Publication number: 20050148777
    Abstract: The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 Wherein Z, X, R1, R 2, R3, and R4 are as described in the specification.
    Type: Application
    Filed: March 16, 2004
    Publication date: July 7, 2005
    Inventors: Jeffery Carter, David Brown, Li Xing, Karl Aston, John Springer, Francis Koszyk, Steven Kramer, Renee Huff, Yi Yu, Bruce Hamper, Subo Laio, Angela Deprow, Theresa Fletcher, E. Hallinan, James Kiefer, David Limburg, Lijuan Wang, Cindy Ludwig, John McCall, John Talley
  • Benzopyran compounds for use in the treatment and prevention of inflammation related conditions
    Publication number: 20050148627
    Abstract: The subject invention concerns methods and compounds that have utility in the treatment of a condition associated with cyclooxygenase-2 mediated disorders. Compounds of particular interest are benzopyrans and their analogs defined by formula 1 Wherein Z, X, R1, R2, R3, and R4 are as described in the specification.
    Type: Application
    Filed: March 16, 2004
    Publication date: July 7, 2005
    Inventors: Jeffery Carter, David Brown, Li Xing, Karl Aston, John Springer, Francis Koszyk, Steven Kramer, Sofya Tsymbalov, Renee Huff, Yi Yu, Bruce Hamper, Subo Laio, Angela Deprow, Theresa Fletcher, E. Hallinan, James Kiefer, David Limburg, Lijuan Wang
  • 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors
    Publication number: 20050113451
    Abstract: The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
    Type: Application
    Filed: November 1, 2004
    Publication date: May 26, 2005
    Applicant: Pharmacia Corporation
    Inventors: Donald Hansen, Ronald Webber, Barnett Pitzele, James Sikorski, Mark Massa, Timothy Hagen, Margaret Grapperhaus, Lijuan Wang, Arija Bergmanis, Steven Kramer, E. Hallinan
  • Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5981511
    Abstract: The current invention discloses hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: March 5, 1997
    Date of Patent: November 9, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Rolando E. Gapud, Timothy J. Hagen, Ann E. Hallinan, Donald W. Hansen, Jr., Robert E. Manning, Suzanne Metz, Barnett S. Pitzele, Foe S. Tjoeng, Mihaly V. Toth, R. Keith Webber
  • Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
    Patent number: 5854251
    Abstract: Aminotetrazole derivatives of the formula (I) wherein the variables are as defined in the disclosure are useful as nitric oxide synthase inhibitors.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: December 29, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Ann E. Hallinan, Donald W. Hansen, Jr., Sofya Tsymbalov
  • Process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-penty noate
    Patent number: 5631399
    Abstract: The present invention relates to a novel process for the preparation of ethyl 3S-[[4-[[4-(aminoiminomethyl)phenyl]amino]-1,4-dioxobutyl]amino]-4-pentyno ate and pharmaceutically acceptable acid addition salt thereof.
    Type: Grant
    Filed: May 14, 1996
    Date of Patent: May 20, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Kevin A. Babiak, Srinivasan Babu, James R. Behling, Mark L. Boys, Kimberly J. Cain-Janicki, Wendel W. Doubleday, Payman Farid, Timothy J. Hagen, E. A. Hallinan, Donald W. Hansen, Jr., Donald E. Korte, Kathleen T. Mc Laughlin, John R. Medich, Sean T. Nugent, Vlasdislav Orlovski, Jung M. Park, Karen B. Peterson, Daniel R. Pilipauskas, Barnett S. Pitzele, Sofya Tsymbalov, Glenn L. Stahl
  • 2-,3-,8-and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating osteoporosis
    Patent number: 5288719
    Abstract: The present invention provides a method for treating osteoporosis in a mammal comprising administering to said mammal a therapeutically-effective amount of a 2-, 3-, 8- and/or 10-substituted dibenzoxazepine compound having a structure of the formula: ##STR1## or a pharmaceutically-acceptable salt thereof, wherein: X is --NH-- or --CH.sub.2 --;Y is(1) --CH.sub.2 -- when X is --NH--, and(2) --NH-- when X is --CH.sub.2 --;R.sup.1 is hydrogen, halogen or --OR.sup.4 ;R.sup.4 is hydrogen, alkyl or ##STR2## Z is oxygen, sulfur, --SO--, --SO.sub.2 -- or --NR.sup.5 --; R.sup.5 is hydrogen or t-butyloxycarbonyl;R.sup.2 is hydrogen, halogen or trifluoromethyl;R.sup.3 is hydrogen, halogen, aryl, heteroaryl in which the heteroatoms are selected from oxygen, nitrogen and/or sulfur, or --NR.sup.6 R.sup.7 ;R.sup.6 and R.sup.7 are each independently hydrogen or alkyl;R.sup.8 is alkyl, aryl or ##STR3## R.sup.9 and R.sup.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: February 22, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Robert K. Husa, Timothy J. Hagen, E. A. Hallinan