Abstract: This invention relates generally to the inhibition of cytomegalovirus (CMV) reactivation in immunosuppressed subjects, including subjects receiving hematopoietic or solid organ transplants. The present invention is particularly relevant for the treatment of CMV reactivation or infection in subjects with graft-versus-hosts disease (GVHD) or under immunosuppressive therapy.

Abstract: Method and systems generate optimized and online targeted messages. Various campaign criteria are provided having different advertising or marketing goals that cause the delivery of targeted messages. Messages may be generated based upon customer data, customer preferences, life events, marketing campaigns, predictive models, and/or propensity scores. For instance, messages may be sent when a propensity threshold score is exceeded indicating a high likelihood of a milestone event, which may be indicative of customer behavior or an event that is relevant to the campaign goal, thereby sending more relevant messages to customers. A milestone propensity score may be calculated using a predictive modeling algorithm having weighted data variables, which may include data provided by the customer or accessed through various sources, such as monitoring customer online interactions with their permission.

Abstract: A sealed terminal has a housing, a cover, a splice tray, an adapter plate, and a splice chip. The cover is connected to the housing to close an interior compartment and has input ports for receiving one or more cables and an output adapter module having a plurality of distribution ports. The splice tray is positioned in the interior compartment and has one or more cable retainers configured to route the one or more cables within the interior compartment. The adapter plate is connected to the splice tray and has a plurality of adapters for connecting the one or more cables to the distribution ports. The splice chip is connected to the splice tray and has a plurality of slots for receiving and routing the one or more cables. The housing includes a radiused wall for routing the cables within the interior compartment without bending the cables.

Abstract: Aspects of the subject technology relate to systems, methods, and computer-readable media for corrosion analysis using magnetic flux leakage measurements. The present technology can magnetic flux leakage data obtained by a magnetic flux leakage tool placed in a pipe within a wellbore and convert the magnetic flux leakage data into image data. Further, the present technology can provide the image data to a machine learning model. The machine learning model is configured to identify one or more physical parameters associated with corrosion present on the pipe.

Abstract: The present disclosure provides, inter alia, antibody-drug conjugates that are useful in treating various diseases such as cancer.

Abstract: An electronic device comprising a cell region comprising stacks of alternating dielectric materials and conductive materials. A pillar region is adjacent to the cell region and comprises storage node segments adjacent to adjoining oxide materials and adjacent to a tunnel region. The storage node segments are separated by a vertical portion of the tunnel region. A high-k dielectric material is adjacent to the conductive materials of the cell region and to the adjoining oxide materials of the pillar region. Additional electronic devices are disclosed, as are methods of forming an electronic device and related systems.

Abstract: A shield (3) is mounted in the driver's side window frame (7) of a vehicle by a lower support (5) containing a flat spring (49) which releasably pushes the shield against the upper window frame. A stand-off (17, 18) at the upper end of the shield spaces other portions the upper edge of the shield from the window frame. A shield handgrip (9) is angled 45° with respect to a lower edge of the shield, to permit the shield to be carried with one apex of the shield up.

Abstract: Embodiments generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incisions to form a top lenticular incision, a bottom lenticular incision of a lens in the subject's eye, an added shape between the top and bottom incisions where the added shape has no corrective power and a transition ring bisecting both the top and bottom lenticular incisions.

Abstract: A downhole device is configured as a selectable hole trimmer. The selectable hole trimmer comprises an upper sleeve affixed inside a body via a stop. A charge sleeve is slidable inside the upper sleeve to provide a pressure to a pressurized volume. A catch sleeve is slidable inside the charge sleeve to align a bypass port and a return port with a drilling mud volume. An actuator is fluidly connected to the pressurized volume via a port. The actuator is configured to provide a pressure to a selectable hole cutter of the body via an actuation port in the transfer sleeve and actuate the selectable hole cutter piston of the selectable hole cutter to move relative to the body, wherein the cutter piston comprises one or more cutters. A manual controller configured to operate the actuator in response to a dropped activation ball.

Abstract: An IBC storage box assembly is elevated from a railcar. A vertical beam is used to elevate the storage box off the railcar so that the storage box is more easily accessed from a rail platform. Additionally, the vertical beam may provide some clearance for the storage box so that the storage box is not impacted by the railcar coupler during transport.

Abstract: An annular elastomeric packer for a blowout preventer includes a plurality of circumferentially spaced inserts, wherein at least one of the plurality of inserts includes a rib, and a foot pivotally coupled to the rib, and an elastomeric body coupled to the plurality of inserts and including an inner surface, wherein the foot is configured to resist deformation of the elastomeric body in response to the blowout preventer actuating from a first position to a second position.

Abstract: An IBC storage box assembly is elevated from a railcar. A vertical beam is used to elevate the storage box off the railcar so that the storage box is more easily accessed from a rail platform. Additionally, the vertical beam may provide some clearance for the storage box so that the storage box is not impacted by the railcar coupler during transport.

Abstract: Embodiments of the present invention comprise; annealing steel sheets (e.g., hot rolled steel sheets or thin cast strip steel); cold rolling the sheets in one or more cold rolling steps (e.g., with annealing steps between multiple cold rolling steps); and performing one or more of tension leveling, a rough rolling, or a coating process on the sheets after cold rolling, without an intermediate annealing step between the final cold rolling step and the tension leveling, the rough rolling, or the coating process, or the customer stamping or final customer annealing. In order to achieve the desired properties for the steel sheet, stamping and final annealing is performed by the customer. The new process provides an electrical steel with the similar, same, or better magnetic properties than an electrical steel manufactured using the traditional processing that utilizes an intermediate annealing step after cold rolling and before the stamping and final annealing.

Abstract: A digital printing system includes a track and a plurality of print heads, wherein the system is configured to index a plurality of containers to or through a plurality of process locations. In embodiments, the track is configured to convey a plurality of containers to or through the plurality of process locations, and the plurality of print heads are configured for digital printing on the plurality of containers.

Abstract: Myocilin-binding agents including antibodies and antigen binding fragments thereof and fusion proteins that immunospecifically bind the olfactomedin domain of myocilin Antibodies that can bind to natively folded myocilin, misfolded myocilin or both are provided herein. The disclosed antibodies and antigen binding fragments and fusion proteins are useful for the detection and extraction of natively folded and the neutralization and degradation of toxic misfolded myocilin from ex vivo samples or the eye.

Abstract: Embodiments of the present invention comprise; annealing steel sheets (e.g., hot rolled steel sheets or thin cast strip steel); cold rolling the sheets in one or more cold rolling steps (e.g., with annealing steps between multiple cold rolling steps); and performing one or more of tension leveling, a rough rolling, or a coating process on the sheets after cold rolling, without an intermediate annealing step between the final cold rolling step and the tension leveling, the rough rolling, or the coating process, or the customer stamping or final customer annealing. In order to achieve the desired properties for the steel sheet, stamping and final annealing is performed by the customer. The new process provides an electrical steel with the similar, same, or better magnetic properties than an electrical steel manufactured using the traditional processing that utilizes an intermediate annealing step after cold rolling and before the stamping and final annealing.

Abstract: The disclosure provides compositions for moistening an oral mucous membrane of a patient in need thereof, comprising propylene glycol and a flavoring agent. Devices comprising the compositions described herein also are provided. The disclosure also provides methods for moistening an oral mucous membrane of a patient in need thereof, methods for stimulating the appetite of a patient in need thereof, and methods for improving a disposition of a patient unable to swallow food or excess liquid using the compositions or devices described herein.

Abstract: An ophthalmic surgical laser system includes: a laser that produces a pulsed laser beam having a pulse energy and pulse repetition rate; a high frequency fast scanner; an XY-scan device; a Z-scan device; and a controller. The controller controls the high frequency scanner to produce a scan line having a scan width; controls the XY-scan device and the Z-scan device to carry out of first sweep of the scan line in a first sweep direction and to carry out a second sweep of the scan line in a second sweep direction that is not parallel to the first sweep direction thereby defining an overlap region. At least one of the pulse energy, repetition rate, XY-scan speed, and the scan width is varied so as to accelerate the cutting speed and reduce the exposure of ophthalmic tissue in the overlap region to multiple exposures of laser pulses configured to modify ophthalmic tissue.

Abstract: A vehicle seat mounting system includes a seat mount plate and a vehicle mount plate. A vertically operable scissor linkage assembly is disposed between the seat mount plate and the vehicle mount plate and is oriented such that respective opposing ends of a first scissor arm and a second scissor arm are each secured to a respective one of the seat mount plate and the vehicle mount plate. A spring assembly is disposed between the seat mount plate and the vehicle mount plate and is oriented to cooperate with the scissor linkage assembly to resist translation between the vehicle mount plate and the seat mount plate. An adjuster assembly cooperates with the spring assembly and is operable to manipulate the proportion of the spring assembly that is available to be engaged to resist motion of the mounting system.