Abstract: A shank assembly for an agricultural implement includes a ground-engaging shank having a shank body. Furthermore, the shank assembly includes a sleeve having a forward wall, an intermediate wall positioned aft of and spaced apart from the forward wall, and an aft wall positioned aft of and spaced apart from the intermediate wall. Additionally, the sleeve includes a first side wall coupled to the forward, intermediate, and aft walls on a first side of the sleeve and a second side wall coupled to the forward, intermediate, and aft walls on a second side of the sleeve. Moreover, the forward wall, the intermediate wall, the first side wall, and the second side wall collectively define a forward passage through which the shank body extends. In addition, the intermediate wall, the aft wall, the first side wall, and the second side wall collectively define an aft passage.

Abstract: In one aspect, an agricultural implement includes a row unit including a frame. A center coulter can be operably coupled with the frame. A knife can be operably coupled with the frame and positioned aft of the center coulter. A diverging gap can be defined between the center coulter and the knife such that the diverging gap increases in width in the forward/aft direction as a location along the knife moves upward.

Abstract: An agricultural implement extends in a fore-aft direction between a forward end and an aft end. The agricultural implement includes a toolbar assembly comprising a central toolbar section and first and second wing toolbar sections pivotably coupled to the central toolbar section, with the central toolbar section configured to be mounted to a work vehicle via a semi-mounted configuration. Additionally, the implement includes first and second lift-assist assemblies pivotably coupled to the central toolbar section and extending outwardly therefrom in a forward direction of travel of the implement such that the lift-assist assemblies are positioned at forward end of the agricultural implement.

Abstract: In one aspect, a rear folding agricultural implement allows for first and second wing sections of a toolbar assembly to be folded relative to a central toolbar section of the toolbar assembly via independently actuatable wing roll sections coupled between the central toolbar section and the respective wing sections.

Abstract: Provided are methods for sensitizing gastrin-associated tumors and/or cancers in subjects to inducers of humoral and cellular immune responses. In some embodiments, the methods relate to administering compositions that have anti-gastrin antibodies, gastrin peptides, and/or nucleic acids that inhibit expression of gastrin gene products to subjects. Also provided are methods for preventing, reducing, and/or eliminating the formation of fibroses associated with tumors and/or cancers, and methods for treating gastrin-associated tumors and/or cancers that include administering to subjects in need thereof a first agent that provides and/or induces an anti-gastrin humoral or cellular immune response in the subject and a second agent that includes one or more stimulators of cellular immune responses against the tumors and/or cancers.

Abstract: The invention relates to saRNA targeting an HNF4a transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.

Abstract: The invention relates to saRNA targeting an HNF4a transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.

Abstract: The invention relates to modified oligonucleotides, e.g., saRNAs useful in upregulating the expression of a target gene and therapeutic compositions comprising such oligonucleotides. Methods of using the oligonucleotides and the therapeutic compositions are also provided.

Abstract: A brake cylinder maintaining system that combines a brake cylinder maintaining check valve and a quick service limiting valve into a single unit to have lower hysteresis, and thus more precise BCM regulation pressure and a smaller pressure offset. The check valve and quick service valve are coupled to provide a single system having multiple valve seats for selective communication between quick service pressure and brake cylinder pressure on one hand, and between a brake cylinder maintaining pressure and brake cylinder pressure on the other hand.

Abstract: A portable game where balls are rolled over a ramp at targets. The game incorporates aspects of bocce ball with the additional challenge of a ramp and different types of targets. The game can roll up into an easily transportable package with all game pieces stored inside the roll. The roll can then be deployed to act as a portion of the game's playing surface in any suitable location. The game consists of balls, a runner, a ramp, and different forms of targets. The runner could be made of slats, fabric, or other materials that are flexible and can be rolled. The balls are similar to bocce balls but could be lighter or smaller for easy transport.

Abstract: Provided are methods for sensitizing gastrin-associated tumors and/or cancers in subjects to inducers of humoral and cellular immune responses. In some embodiments, the methods relate to administering compositions that have anti-gastrin antibodies, gastrin peptides, and/or nucleic acids that inhibit expression of gastrin gene products to subjects. Also provided are methods for preventing, reducing, and/or eliminating the formation of fibroses associated with tumors and/or cancers, and methods for treating gastrin-associated tumors and/or cancers that include administering to subjects in need thereof a first agent that provides and/or induces an anti-gastrin humoral or cellular immune response in the subject and a second agent that includes one or more stimulators of cellular immune responses against the tumors and/or cancers.

Abstract: Provided are methods for sensitizing gastrin-associated tumors and/or cancers in subjects to inducers of humoral and cellular immune responses. In some embodiments, the methods relate to administering compositions that have anti-gastrin antibodies, gastrin peptides, and/or nucleic acids that inhibit expression of gastrin gene products to subjects. Also provided are methods for preventing, reducing, and/or eliminating the formation of fibroses associated with tumors and/or cancers, and methods for treating gastrin-associated tumors and/or cancers that include administering to subjects in need thereof a first agent that provides and/or induces an anti-gastrin humoral or cellular immune response in the subject and a second agent that includes one or more stimulators of cellular immune responses against the tumors and/or cancers.

Abstract: The invention relates to saRNA targeting an HNF4a transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.

Abstract: The invention relates to saRNA targeting an HNF4a transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.

Abstract: The invention relates to saRNA targeting an HNF4a transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.

Abstract: The invention relates to saRNA targeting an HNF4a transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.

Abstract: The invention relates to saRNA targeting a C/EBP? transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.

Abstract: A brake cylinder maintaining system that combines a brake cylinder maintaining check valve and a quick service limiting valve into a single unit to have lower hysteresis, and thus more precise BCM regulation pressure and a smaller pressure offset. The check valve and quick service valve are coupled to provide a single system having multiple valve seats for selective communication between quick service pressure and brake cylinder pressure on one hand, and between a brake cylinder maintaining pressure and brake cylinder pressure on the other hand.

Abstract: A brake cylinder maintaining system that combines a brake cylinder maintaining check valve and a quick service limiting valve into a single unit to have lower hysteresis, and thus more precise BCM regulation pressure and a smaller pressure offset. The check valve and quick service valve are coupled to provide a single system having multiple valve seats for selective communication between quick service pressure and brake cylinder pressure on one hand, and between a brake cylinder maintaining pressure and brake cylinder pressure on the other hand.

Abstract: The invention relates to saRNA targeting a C/EBP? transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.