Patents by Inventor E. James Petersson

E. James Petersson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thioamide-modified peptides and uses thereof
    Patent number: 11891425
    Abstract: The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: February 6, 2024
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: E. James Petersson, Alan Saghatelian
  • THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF
    Publication number: 20210198338
    Abstract: The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
    Type: Application
    Filed: February 12, 2021
    Publication date: July 1, 2021
    Inventors: E. James PETERSSON, Alan SAGHATELIAN
  • Method of stabilizing a bioactive peptide against protease hydrolysis
    Patent number: 10947290
    Abstract: The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: March 16, 2021
    Assignees: The Trustees of the University of Pennsylvania, President and Fellows of Harvard College
    Inventors: E. James Petersson, Alan Saghatelian
  • NOVEL THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF
    Publication number: 20190085044
    Abstract: The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
    Type: Application
    Filed: December 4, 2018
    Publication date: March 21, 2019
    Inventors: E. James PETERSSON, Alan SAGHATELIAN
  • Thioamide-modified peptides and uses thereof
    Patent number: 10189884
    Abstract: The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: January 29, 2019
    Assignees: The Trustees of the University of Pennsylvania, President and Fellows of Harvard College
    Inventors: E. James Petersson, Alan Saghatelian
  • NOVEL THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF
    Publication number: 20170044231
    Abstract: The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
    Type: Application
    Filed: April 28, 2015
    Publication date: February 16, 2017
    Inventors: E. James PETERSSON, Alan SAGHATELIAN
  • Methods of modifying N-termini of a peptide or protein using transferases
    Patent number: 9376700
    Abstract: The invention includes a selective method of modifying the N-terminus of a protein using an aminoacyl tRNA transferase. In certain embodiments, the method comprises contacting a solution of the protein or peptide with a transferase and a derivative of a molecule, whereby the N-terminus of the protein or peptide is derivatized with the molecule.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: June 28, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: E. James Petersson
  • ONE STEP N-TERMINAL TAGGING OF PROTEINS
    Publication number: 20150140605
    Abstract: The invention includes a selective method of modifying the N-terminus of a protein using an aminoacyl tRNA transferase. In certain embodiments, the method comprises contacting a solution of the protein or peptide with a transferase and a derivative of a molecule, whereby the N-terminus of the protein or peptide is derivatized with the molecule.
    Type: Application
    Filed: June 13, 2013
    Publication date: May 21, 2015
    Inventor: E. James Petersson