Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in tobacco plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for a root-specific nicotine demethylases, CYP82E10, and variants thereof, that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Compositions of the invention also include tobacco plants, or plant parts thereof, comprising a mutation in a gene encoding a CYP82E10 nicotine demethylase, wherein the mutation results in reduced expression or function of the CYP82E10 nicotine demethylase. Seed of these tobacco plants, or progeny thereof, and tobacco products prepared from the tobacco plants of the invention, or from plant parts or progeny thereof, are also provided. Methods for reducing the level of nornicotine, or reducing the rate of conversion of nicotine to nornicotine, in a tobacco plant, or plant part thereof are also provided.

Abstract: An example method includes determining identifying information for a vehicle to be serviced. The method further includes receiving at least one symptom identifier for the vehicle. The method further includes sending a request over a communication network to a remote server for a PID filter list for the vehicle, the request comprising the identifying information for the vehicle and the at least one symptom identifier for the vehicle. The method additionally includes receiving a response to the request over the communication network from the remote server, the response comprising the PID filter list for the vehicle. The method further includes determining, based on the PID filter list for the vehicle, a symptom-based subset of PIDs for the vehicle from a set of available PIDs. The method additionally includes displaying, on a display interface, the symptom-based subset of PIDs for the vehicle.

Abstract: An illumination device and method are provided for controlling light-emitting diodes (LEDs). The LEDs (specifically, the LED loads) are controlled, e.g., brightness and color of the LED loads, independent of a phase-cut dimmer applied to the AC mains feeding a DC power supply. The power supply is active dependent upon the duration of a conduction angle supplied from the dimmer The power supply, however, produces drive currents that are independent from the conduction angle by using a two-stage power supply and a relatively slow and fast control loops that are controlled through a microprocessor-based control circuit. Parameters stored in the control circuit are drawn by the microprocessor to control the two-stage power supply to produce the drive currents independent and decoupled from the conduction angle yet dependent on the controller parameters.

Abstract: An implant for insertion within a maxillofacial bone of a patient including a tapered body and one or more threads formed along the body. The one or more threads on one or more lead threads include multiple thread forms including both three-dimensional stabilization thread and standard thread (e.g. v-thread, buttress thread, etc.) forms. The one or more threads including the multiple thread forms provides for maximizing the restriction of lateral movement of the implant within a full or partial osteotomy.

Abstract: A lighting device, such as a light-emitting diode (LED) light source, may operate in an interim operable state to avoid and/or prevent undesirable characteristics in the light emitted by the lighting device (e.g., strobing and/or flickering of a brightness of the light and/or shifting or change of a color of the light). When operating in a normal state, the control circuit may determine if a measured value of a first operational characteristic (e.g., a forward voltage of an emitter of the lighting device) is outside of a range and operate in the interim operable state if the measured value of the first operational characteristic is outside of the range. When operating in the interim operable state, the control circuit may adjust a drive current for the emitter in response to a measured value of a second operational characteristic (e.g., a forward voltage of a detector of the lighting device).

Abstract: The invention provides gene targets whose restoration leads to genome stabilization in host cells, such as Chinese Hamster Ovary (CHO) cells. Many DNA repair genes are mutated in CHO cells which compromises their ability to repair naturally occurring DNA damage, in particular double-strand breaks (DSBs). Unrepaired DSBs can give rise to chromosomal instability which, in turn, can lead to loss of transgenes from the genome. As a consequence, protein titer can drop significantly, rendering protein production unprofitable. The invention provides a set of mutated DNA repair genes whose restoration yields significant improvement in DSB repair, genome stability, and protein titer.

Abstract: An illumination device, system, and method are provided herein for emulating sunlight along a daytime or nighttime locus. Color temperature is determined using a first color temperature curve that includes data representative of a first color temperature as a function of a time of day. In response to a request to a change in brightness of one or more LED chains, a target color temperature output as a function of the current time of day is determined using a second color temperature curve based on the requested change in brightness. The second color temperature curve includes the target color temperature corresponding to the determined current time of day. The target color temperature output includes a lesser change in color temperature at solar noon than the change in color temperature at sunrise and sunset.

Abstract: An instrument driver comprises a base and a jaw assembly coupled to the base. The jaw assembly includes a first jaw having a gripping surface and a second jaw having a gripping surface. The instrument driver further comprises a driver assembly operably coupled to the jaw assembly to advance an elongated member relative to the base by translating the first and second jaws toward each other, thereby closing the jaw assembly and gripping the member between the respective gripping surfaces of the first and second jaws, translating the jaw assembly in a first axial direction when the jaw assembly is closed, translating the first and second jaws away from each other, thereby opening the jaw assembly and releasing the member from between the respective gripping surfaces of the first and second jaws, and translating the jaw assembly in a second axial direction when the jaw assembly is opened.

Abstract: An illumination device and method are provided for controlling light-emitting diodes (LEDs). The LEDs (specifically, the LED loads) are controlled, e.g., brightness and color of the LED loads, independent of a phase-cut dimmer applied to the AC mains feeding a DC power supply. The power supply is active dependent upon the duration of a conduction angle supplied from the dimmer. The power supply, however, produces drive currents that are independent from the conduction angle by using a two-stage power supply and a relatively slow and fast control loops that are controlled through a microprocessor-based control circuit. Parameters stored in the control circuit are drawn by the microprocessor to control the two-stage power supply to produce the drive currents independent and decoupled from the conduction angle yet dependent on the controller parameters.

Abstract: A lighting device, such as a light-emitting diode (LED) light source, may operate in an interim operable state to avoid and/or prevent undesirable characteristics in the light emitted by the lighting device (e.g., strobing and/or flickering of a brightness of the light and/or shifting or change of a color of the light). When operating in a normal state, the control circuit may determine if a measured value of a first operational characteristic (e.g., a forward voltage of an emitter of the lighting device) is outside of a range and operate in the interim operable state if the measured value of the first operational characteristic is outside of the range. When operating in the interim operable state, the control circuit may adjust a drive current for the emitter in response to a measured value of a second operational characteristic (e.g., a forward voltage of a detector of the lighting device).

Abstract: An illumination device and method are provided herein for calibrating individual LEDs in the illumination device to obtain a desired luminous flux and a desired chromaticity of the device over changes in drive current, temperature, and over time as the LEDs age. The calibration method may include subjecting the illumination device to a first ambient temperature, successively applying at least three different drive currents to a first LED to produce illumination at three or more different levels of brightness, obtaining a plurality of optical measurements from the illumination produced by the first LED at each of the at least three different drive currents, obtaining a plurality of electrical measurements from the photodetector and storing results of the obtaining steps within the illumination device to calibrate the first LED at the first ambient temperature.

Abstract: Various embodiments of the present disclosure evaluate transcription accuracy. In some implementations, the system normalizes a first transcription of an audio file and a baseline transcription of the audio file. The baseline transcription can be used as an accurate transcription of the audio file. The system can further determine an error rate of the first transcription by aligning each portion of the first transcription with the portion of the baseline transcription, and assigning a label to each portion based on a comparison of the portion of the first transcription with the portion of the baseline transcription.

Abstract: A lighting device, such as a controllable light-emitting diode (LED) light source, may execute a self-calibration procedure to compensate for changes in an optical system of the lighting device that may have occurred after an initial factory calibration procedure. The lighting device may include an emitter, a detector that generates a detector signal in response to detected light, a memory that stores a curve defining an optical compensation value with respect to a measured forward voltage of the detector, and a control circuit configured to receive a measured value of a luminous flux of the light emitted by the emitter that may be determined in response to the detector signal and based on the optical compensation value. The control circuit may adjust the curve defining the optical compensation value in response to a difference between the measured value and an expected value of the luminous flux.

Abstract: A method in an aircraft for energy reduction is disclosed. The method includes: determining a starting point location, altitude and airspeed for a stable approach for landing at a diversion airport; and determining a vertical strategy for achieving the starting point altitude and airspeed by identifying a region of opportunity for adjusting the speed and altitude and identifying a plurality of energy reduction strategies for achieving the starting point altitude and airspeed while in the region of opportunity based on a speed mode during the stable approach. The method further comprises causing a graphic display to be displayed that lists for selection each of the plurality of identified strategies, detailed maneuver information for strategy implementation, and costs for implementing each identified strategy; and causing to be displayed, responsive to flight crew selection, a lateral view and vertical view of a proposed trajectory based on a selected identified strategy.

Abstract: Conjugate (KTAC) compounds that include a peptidic kappa opioid receptor agonist linked through a protease-sensitive linker and/or acid-sensitive linker to an antibody molecule are provided. The linker may include spacer regions on either side of the protease sensitive cleavage site. The antibody can be a monoclonal antibody such as a therapeutic monoclonal antibody. The KTAC compounds may be incorporated into pharmaceutical compositions useful for the treatment of diseases and conditions, particularly those that include an inflammatory component.

Abstract: An instrument driver comprises a base and a jaw assembly coupled to the base. The jaw assembly includes a first jaw having a gripping surface and a second jaw having a gripping surface. The instrument driver further comprises a driver assembly operably coupled to the jaw assembly to advance an elongated member relative to the base by translating the first and second jaws toward each other, thereby closing the jaw assembly and gripping the member between the respective gripping surfaces of the first and second jaws, translating the jaw assembly in a first axial direction when the jaw assembly is closed, translating the first and second jaws away from each other, thereby opening the jaw assembly and releasing the member from between the respective gripping surfaces of the first and second jaws, and translating the jaw assembly in a second axial direction when the jaw assembly is opened.

Abstract: Disclosed are methods, systems, and a non-transitory computer-readable medium for regenerating at least a portion of a flight plan of a vehicle. The method may include generating an adjustment to a speed, an altitude, and/or a heading for one or more locations along a flight path within at least one of a predetermined distance of the vehicle and a predetermined window of time, based on received speed data, altitude data, and flight path data, including a subset of points along each boom footprint included in the flight path data, and a permissible threshold boom value for each of the one or more locations. The method may also include regenerating a portion of a flight plan corresponding to the one or more locations, based on the generated adjustment to the speed, altitude, and/or heading for the one or more locations.

Abstract: Systems and methods may be used for monitoring and identifying failure in flight management systems. For example, a method may include: calculating, using a first flight management system, a first value of a guidance command for controlling an aircraft for an RNP AP procedure; receiving a second value of the guidance command from a second flight management system; comparing the first value with the second value to determine whether the first value matches the second value; upon determining that the first value does not match the second value, using a flight management system monitor to determine, from the first flight management system and the second flight management system, a flight management system that has computed a correct value of the guidance command; and generating a message indicating that the determined flight management system is to be used to guide the aircraft.

Abstract: Methods and systems are provided for engaging a vertical navigational descent (VNAV/DES) mode of a flight management system (FMS) for an aircraft. The method comprises retrieving a preset vertical navigation (VNAV) profile for a descent path of the aircraft that is stored in the FMS. The current flight path angle (FPA) and vertical speed (VS) of the aircraft is determined and intercept parameters are calculated to intercept the preset VNAV profile with the VNAV/DES mode of the FMS. The intercept parameters are calculated based on the current FPA and VS and displayed to an aircrew member of the aircraft on a visual display device. The aircrew member is allowed to accept the intercept parameters with the VNAV/DES mode of the FMS.

Abstract: An illumination device and method are provided herein for calibrating individual LEDs in the illumination device to obtain a desired luminous flux and a desired chromaticity of the device over changes in drive current, temperature, and over time as the LEDs age. The calibration method may include subjecting the illumination device to a first ambient temperature, successively applying at least three different drive currents to a first LED to produce illumination at three or more different levels of brightness, obtaining a plurality of optical measurements from the illumination produced by the first LED at each of the at least three different drive currents, obtaining a plurality of electrical measurements from the photodetector and storing results of the obtaining steps within the illumination device to calibrate the first LED at the first ambient temperature.