Patents by Inventor E. Lynn Zechiedrich

E. Lynn Zechiedrich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USING MINIVECTORS TO TREAT IDIOPATHIC PULMONARY FIBROSIS
    Publication number: 20240100189
    Abstract: MiniVectors and compositions containing MiniVectors that target genes implicated in IPF selected from CDH11, STAT3, STAT6, FoxM1, MDM2, TGF?, SMAD, PDGFA, or TLR4 and/or increase intracellular levels of reduced glutathione, relaxin, and p53, are provided, along with uses in the treatment of idiopathic pulmonary fibrosis.
    Type: Application
    Filed: September 7, 2022
    Publication date: March 28, 2024
    Applicants: Twister Biotech, Inc, Baylor College of Medicine
    Inventors: E. Lynn ZECHIEDRICH, Lirio Milenka AREVALO-SOLIZ, Daniel James CATANESE, JR., Jonathan Marcus FOGG, Christopher E. COKER
  • ULTRAPURE MINIVECTORS FOR GENE THERAPY
    Publication number: 20240093226
    Abstract: MiniVectors and compositions containing MiniVectors that are ultrapure, and methods of making and using ultrapure MiniVectors for gene therapy uses, including long term repeated gene therapy uses.
    Type: Application
    Filed: September 8, 2022
    Publication date: March 21, 2024
    Applicants: BAYLOR COLLEGE OF MEDICINE, BAYLOR COLLEGE OF MEDICINE
    Inventors: E. Lynn ZECHIEDRICH, Jonathan Marcus FOGG, Lirio Milenka AREVALO-SOLIZ, Daniel James CATANESE, Christopher E. COKER
  • TREATMENT OF LIVER CANCER OR LIVER FIBROSIS
    Publication number: 20230190955
    Abstract: Compositions containing MiniVectors and gene therapy uses, including long term repeated gene therapy uses, to treat liver fibrosis or liver cancer.
    Type: Application
    Filed: October 20, 2022
    Publication date: June 22, 2023
    Applicants: BAYLOR COLLEGE OF MEDICINE, TWISTER BIOTECH, INC.
    Inventors: E. LYNN ZECHIEDRICH, LIRIO MILENKA AREVALO-SOLIZ, Daniel James CATANESE, JR., Jonathan Marcus FOGG, Christopher E. COKER, SANDEEP AGARWAL
  • USING MINIVECTORS TO TREAT OVARIAN CANCER
    Publication number: 20200048716
    Abstract: MiniVectors and compositions containing MiniVectors that target ovarian cancer genes selected from FOXM1, AKT, CENPA, PLK1, CDC20, BIRC5, AURKB, CCNB1, CDKN3, BCAM-AKT2, CDKN2D-WDFY2, SLC25A6, CIP2A, CD133, ALDH1A1, CD44, SALL4, and/or PRDM16, alone or in any combination, are provided, along with uses in the treatment of ovarian cancer.
    Type: Application
    Filed: November 5, 2018
    Publication date: February 13, 2020
    Inventors: E. Lynn Zechiedrich, Martin M. Matzuk, Laising Yen, Zhifeng Yu, Lirio Milenka Arevalo-Soliz, Daniel James Catanese, JR., Jonathan Marcus Fogg, Christopher Elbert Coker
  • TARGETING MINIVECTORS TO SPECIFIC TISSUE USING SHAPE
    Publication number: 20180305701
    Abstract: Minivectors having defined, non-transient shapes as determined by sequence are provided, along with uses in the targeting delivery of such minivectors to target tissues for preferential gene delivery. Method of designing and making shaped minivectors are also provided.
    Type: Application
    Filed: March 13, 2018
    Publication date: October 25, 2018
    Inventors: E. Lynn ZECHIEDRICH, Jonathan Marcus FOGG, Qian WANG, B. Montgomery PETTITT
  • Supercoiled minicircle DNA for gene therapy applications
    Patent number: 9267150
    Abstract: The present invention relates to nucleic acid molecule compositions comprising minivectors encoding a nucleic acid sequence and methods of gene therapy using minivectors encoding a nucleic acid sequence.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: February 23, 2016
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, Daniel James Catanese, Jr., Erol Bakkalbasi, Brian E. Gilbert
  • SUPERCOILED MINIVECTORS AS A TOOL FOR DNA REPAIR, ALTERATION AND REPLACEMENT
    Publication number: 20150376645
    Abstract: In some embodiments the present disclosure provides a composition for targeted alteration of a DNA sequence and methods of altering the targeted DNA sequence using the composition. In some embodiments such a composition comprises a MiniVector comprising a nucleic acid sequence template for homology-directed repair, alteration, or replacement of the targeted DNA sequence within a cell in vivo or in vitro, where the MiniVector lacks both a bacterial origin of replication and an antibiotic selection gene, and wherein the Mini Vector has a size up to about 2,500 base pairs.
    Type: Application
    Filed: May 30, 2013
    Publication date: December 31, 2015
    Applicants: BAYLOR COLLEGE OF MEDICINE, UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATION
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, Daniel James Catanese, JR., Nancy Maizel, Olivier Humbert
  • Supercoiled minivectors for gene therapy applications
    Patent number: 8729044
    Abstract: The present invention relates to nucleic acid molecule compositions comprising MiniVectors™ encoding a nucleic acid sequence and methods of gene therapy using MiniVectors encoding a nucleic acid sequence.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: May 20, 2014
    Assignee: Baylor College of Medicine
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, Daniel James Catanese, Jr., Erol Bakkalbasi, Brian E. Gilbert
  • GENOMIC APPROACH TO THE IDENTIFICATION OF BIOMARKERS FOR ANTIBIOTIC RESISTANCE AND SUSCEPTIBILITY IN CLINICAL ISOLATES OF BACTERIAL PATHOGENS
    Publication number: 20140030712
    Abstract: In certain embodiments, the present invention concerns genotypic identification of bacteria that are resistant to a bacteria and subsequent determination of an appropriate therapy. In specific embodiments, a high-throughput genotypic detection method for biomarkers for antibiotic resistance and susceptibility allows efficient prescription practice and increases the likelihood of a successful therapeutic outcome. In certain embodiments, the information from the genotypic detection method is utilized for determining antibiotics that should be avoided or, alternatively, employed.
    Type: Application
    Filed: February 1, 2012
    Publication date: January 30, 2014
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: E. Lynn Zechiedrich, Michelle C. Swick, Richard S. Sucgang
  • SUPERCOILED MINICIRCLE DNA FOR GENE THERAPY APPLICATIONS
    Publication number: 20130316449
    Abstract: The present invention relates to nucleic acid molecule compositions comprising minivectors encoding a nucleic acid sequence and methods of gene therapy using minivectors encoding a nucleic acid sequence.
    Type: Application
    Filed: April 30, 2013
    Publication date: November 28, 2013
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, Danniel James Catanese, JR., Erol Bakkalbasi, Brian E. Gilbert
  • Supercoiled minivectors™ for gene therapy applications
    Patent number: 8460924
    Abstract: The present invention relates to nucleic acid molecule compositions comprising MiniVectors™ encoding a nucleic acid sequence and methods of gene therapy using MiniVectors encoding a nucleic acid sequence.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: June 11, 2013
    Assignee: Baylor College of Medicine
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, Daniel James Catanese, Jr., Erol Bakkalbasi, Brian E. Gilbert
  • SUPERCOILED MINICIRCLE DNA FOR GENE THERAPY APPLICATIONS
    Publication number: 20130085173
    Abstract: The present invention relates to nucleic acid molecule compositions comprising minivectors encoding a nucleic acid sequence and methods of gene therapy and prophylaxis against infection using minivectors encoding a nucleic acid sequence.
    Type: Application
    Filed: March 7, 2012
    Publication date: April 4, 2013
    Applicant: Baylor College of Medicine
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, Daniel James Catanese, Erol Bakkalbasi, Brian E. Gilbert
  • SUPERCOILED MINICIRCLE DNA FOR GENE THERAPY APPLICATIONS
    Publication number: 20120302625
    Abstract: The present invention relates to nucleic acid molecule compositions comprising minivectors encoding a nucleic acid sequence and methods of gene therapy using minivectors encoding a nucleic acid sequence.
    Type: Application
    Filed: October 15, 2010
    Publication date: November 29, 2012
    Applicant: BAYLOR COLLEGE OF MEDICINE
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, Daniel James Catanese, JR., Erol Bakkalbasi, Brian E. Gilbert
  • SUPERCOILED MINICIRCLE DNA FOR GENE THERAPY APPLICATIONS
    Publication number: 20110160284
    Abstract: The present invention relates to nucleic acid molecule compositions comprising minivectors encoding a nucleic acid sequence and methods of gene therapy using minivectors encoding a nucleic acid sequence.
    Type: Application
    Filed: October 15, 2010
    Publication date: June 30, 2011
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, Daniel James Catanese, JR., Erol Bakkalbasi, Brian E. Gilbert
  • Generation of minicircle DNA with physiological supercoiling
    Patent number: 7622252
    Abstract: Methods for the production of supercoiled DNA minicircles and their use as substrates are described herein.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: November 24, 2009
    Assignees: Baylor College of Medicine, The Regents of the University of California
    Inventors: E. Lynn Zechiedrich, Jonathan Fogg, John Perona