Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: A method, non-transitory computer readable medium and timing computing device for subnanosecond time synchronization. A difference between synchronized measurements of one of a plurality of satellite signals from a reference receiver and another receiver for each of N values within a cycle is determined. A clock bias error is calculated for each of the N values. The calculated clock bias errors are stored in a vector over time for each of the N values, with one of the vectors for each of the N values. A trajectory of the vectors over time is determined. The one of the vectors with a best convergence over time is selected. A timing signal is adjusted based on the N value for the selected one of the vectors with the best convergence over time.

Abstract: A snare system includes a trap body including an aperture, a trigger plate assembly disposed within the trap body such that the trigger plate assembly is accessible through the aperture, a snare assembly placeable about the trap body, and at least one snare release assembly operatively linked with the trap body. The trigger plate assembly is movable between an armed position and an activated position. The snare release assembly normally biases the trigger plate assembly into the armed position. Furthermore, the snare release assembly disengages the snare assembly from the trap body when the trigger plate assembly moves from the armed position to the activated position. Upon disengagement from the trap body, the snare assembly moves to capture an animal's limb.

Abstract: Disclosed are systems and apparatus adapted to control a temperature of a process fluid in an instrument. In one aspect, the systems and apparatus are adapted to control fluid temperature provided to a feed tank. The feed tank may feed a metering system and metering line of an instrument such as a clinical analyzer. The fluid temperature control system includes a process fluid inflow, a process fluid outflow, a first fluid path fluidly coupled to the process fluid inflow and outflow, and at least one heat exchanger thermally coupled to the first fluid path, wherein the heat exchanger is adapted to extract heat for at least one heat-generating component of the instrument. Controlling a temperature of the process fluid at the feed tank improves metering accuracy. Methods of operating the system are provided, as are other aspects.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: A snare system includes a trap body including an aperture, a trigger plate assembly disposed within the trap body such that the trigger plate assembly is accessible through the aperture, a snare assembly placeable about the trap body, and at least one snare release assembly operatively linked with the trap body. The trigger plate assembly is movable between an armed position and an activated position. The snare release assembly normally biases the trigger plate assembly into the armed position. Furthermore, the snare release assembly disengages the snare assembly from the trap body when the trigger plate assembly moves from the armed position to the activated position. Upon disengagement from the trap body, the snare assembly moves to capture an animal's limb.

Abstract: The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: An arm for supporting a monitor comprises a telescoping arm assembly, a support member and a cord storage device. The telescoping arm assembly has at least first and second telescoping members telescopingly movable relative to each other, a distal end configured to support a monitor and a hollow interior through which at least one cord from the monitor can be routed. The support member is connected to the telescoping arm assembly proximally of the distal end to suspend the telescoping arm assembly. The support member is configured to extend transverse to the telescoping arm assembly and to be attached to a support surface. The cord storage device is positioned at least partially within at least one of the telescoping arm assembly or the support member. The cord storage device winds and unwinds the cord from the monitor as the first and second telescoping members are moved toward and away from each other, respectively.

Abstract: A method, non-transitory computer readable medium and timing computing device for subnanosecond time synchronization. A difference between synchronized measurements of one of a plurality of satellite signals from a reference receiver and another receiver for each of N values within a cycle is determined. A clock bias error is calculated for each of the N values. The calculated clock bias errors are stored in a vector over time for each of the N values, with one of the vectors for each of the N values. A trajectory of the vectors over time is determined. The one of the vectors with a best convergence over time is selected. A timing signal is adjusted based on the N value for the selected one of the vectors with the best convergence over time.

Abstract: An arm for supporting a monitor comprises a telescoping arm assembly, a support member and a cord storage device. The telescoping arm assembly has at least first and second telescoping members telescopingly movable relative to each other, a distal end configured to support a monitor and a hollow interior through which at least one cord from the monitor can be routed. The support member is connected to the telescoping arm assembly proximally of the distal end to suspend the telescoping arm assembly. The support member is configured to extend transverse to the telescoping arm assembly and to be attached to a support surface. The cord storage device is positioned at least partially within at least one of the telescoping arm assembly or the support member. The cord storage device winds and unwinds the cord from the monitor as the first and second telescoping members are moved toward and away from each other, respectively.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: A prosthetic heart valve assembly comprises a plurality of leaflets configured to replace the function of a native heart valve. Each leaflet comprises laminar pericardium tissue. Each leaflet has a coaptation edge formed by laser cutting. The tissue layers of each leaflet are fused together along an entire length of the coaptation edge, and tissue adjacent each coaptation edge does not have significant thermal energy damage.

Abstract: An integrated circuit has a first and second voltage supply rails with first and second voltage levels and a gated voltage supply rail. Each of the circuit elements is connected either between the first and second voltage supply rails or between the gated rail and the second voltage rail. A source circuit structure comprising one or more circuit elements provides an input signal maintained at a static value during a power gated mode of operation. At least one recipient circuit structure requires receipt of the input signal at the static value during the power gated mode of operation. A distribution network comprises a first subset of circuit elements which pull their output to the first voltage level then the input signal has the static value, and a second subset of circuit elements which pull their output to the second voltage level when the input signal has the static value.

Abstract: An axle assembly for a motorcycle having a plurality of drive wheels. The axle assembly is configured to permit a user to replace an endless power-transmitting element without substantially disassembling the axle housing assembly.

Abstract: An axle assembly for a motorcycle having a plurality of drive wheels. The axle assembly is configured to permit a user to replace an endless power-transmitting element without substantially disassembling the axle housing assembly.

Abstract: Cocoa components having enhanced levels of cocoa polyphenols, processes for producing the cocoa components while conserving a significant amount of the cocoa polyphenols, compositions containing the cocoa components or the cocoa polyphenols, and methods of using the cocoa components or the cocoa polyphenols for improving the health of a mammal are described. The cocoa components include partially and fully defatted cocoa solids, cocoa nibs and fractions derived therefrom, cocoa polyphenol extracts, cocoa butter, chocolate liquors, and mixtures thereof. The invention provides processes for extracting fat from cocoa beans and for otherwise processing cocoa beans to yield a cocoa component having conserved concentrations of polyphenols relative to the starting materials.

Abstract: Disclosed are systems and apparatus adapted to control a temperature of a process fluid in an instrument. In one aspect, the systems and apparatus are adapted to control fluid temperature provided to a feed tank. The feed tank may feed a metering system and metering line of an instrument such as a clinical analyzer. The fluid temperature control system includes a process fluid inflow, a process fluid outflow, a first fluid path fluidly coupled to the process fluid inflow and outflow, and at least one heat exchanger thermally coupled to the first fluid path, wherein the heat exchanger is adapted to extract heat for at least one heat-generating component of the instrument. Controlling a temperature of the process fluid at the feed tank improves metering accuracy. Methods of operating the system are provided, as are other aspects.