Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: A method and device for reducing paravalvular leakage upon implantation of a replacement heart valve is provided. The valve assembly includes a tissue or bioprosthetic heart valve attached to an anchoring structure. The anchoring structure includes an inlet rim that is substantially C-shaped in cross section to form a concave landing zone. The anchoring structure self-seats when implanted in the sinus of a patient with the proximal and distal ends of the C-shaped inlet rim pushed against the aorta to effectively prevent paravalvular leakage.

Abstract: A dental light comprises at least one light emitting diode light source configured to produce a light beam and at least one collimating lens system situated to receive the light beam. The collimating lens system is configured to collect and collimate the light beam. The collimating lens system can additionally modify the beam through controlled diffusion or shape the beam using an aperture.

Abstract: A dental light comprises at least one light emitting diode light source configured to produce a light beam and at least one collimating lens system situated to receive the light beam. The collimating lens system is configured to collect and collimate the light beam. The collimating lens system can additionally modify the beam through controlled diffusion or shape the beam using an aperture.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: A method, non-transitory computer readable medium and timing computing device for subnanosecond time synchronization. A difference between synchronized measurements of one of a plurality of satellite signals from a reference receiver and another receiver for each of N values within a cycle is determined. A clock bias error is calculated for each of the N values. The calculated clock bias errors are stored in a vector over time for each of the N values, with one of the vectors for each of the N values. A trajectory of the vectors over time is determined. The one of the vectors with a best convergence over time is selected. A timing signal is adjusted based on the N value for the selected one of the vectors with the best convergence over time.

Abstract: A snare system includes a trap body including an aperture, a trigger plate assembly disposed within the trap body such that the trigger plate assembly is accessible through the aperture, a snare assembly placeable about the trap body, and at least one snare release assembly operatively linked with the trap body. The trigger plate assembly is movable between an armed position and an activated position. The snare release assembly normally biases the trigger plate assembly into the armed position. Furthermore, the snare release assembly disengages the snare assembly from the trap body when the trigger plate assembly moves from the armed position to the activated position. Upon disengagement from the trap body, the snare assembly moves to capture an animal's limb.

Abstract: Disclosed are systems and apparatus adapted to control a temperature of a process fluid in an instrument. In one aspect, the systems and apparatus are adapted to control fluid temperature provided to a feed tank. The feed tank may feed a metering system and metering line of an instrument such as a clinical analyzer. The fluid temperature control system includes a process fluid inflow, a process fluid outflow, a first fluid path fluidly coupled to the process fluid inflow and outflow, and at least one heat exchanger thermally coupled to the first fluid path, wherein the heat exchanger is adapted to extract heat for at least one heat-generating component of the instrument. Controlling a temperature of the process fluid at the feed tank improves metering accuracy. Methods of operating the system are provided, as are other aspects.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.

Abstract: A snare system includes a trap body including an aperture, a trigger plate assembly disposed within the trap body such that the trigger plate assembly is accessible through the aperture, a snare assembly placeable about the trap body, and at least one snare release assembly operatively linked with the trap body. The trigger plate assembly is movable between an armed position and an activated position. The snare release assembly normally biases the trigger plate assembly into the armed position. Furthermore, the snare release assembly disengages the snare assembly from the trap body when the trigger plate assembly moves from the armed position to the activated position. Upon disengagement from the trap body, the snare assembly moves to capture an animal's limb.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: An arm for supporting a monitor comprises a telescoping arm assembly, a support member and a cord storage device. The telescoping arm assembly has at least first and second telescoping members telescopingly movable relative to each other, a distal end configured to support a monitor and a hollow interior through which at least one cord from the monitor can be routed. The support member is connected to the telescoping arm assembly proximally of the distal end to suspend the telescoping arm assembly. The support member is configured to extend transverse to the telescoping arm assembly and to be attached to a support surface. The cord storage device is positioned at least partially within at least one of the telescoping arm assembly or the support member. The cord storage device winds and unwinds the cord from the monitor as the first and second telescoping members are moved toward and away from each other, respectively.

Abstract: A method, non-transitory computer readable medium and timing computing device for subnanosecond time synchronization. A difference between synchronized measurements of one of a plurality of satellite signals from a reference receiver and another receiver for each of N values within a cycle is determined. A clock bias error is calculated for each of the N values. The calculated clock bias errors are stored in a vector over time for each of the N values, with one of the vectors for each of the N values. A trajectory of the vectors over time is determined. The one of the vectors with a best convergence over time is selected. A timing signal is adjusted based on the N value for the selected one of the vectors with the best convergence over time.

Abstract: A method of making a blood product for administration to patient animals to prevent or mitigate a specific condition or disease includes pre-treating one or more donor animals, collecting blood from the donor animals after pre-treatment, and processing the collected blood to make a blood product for administering to one or more patient animals. The pre-treatment step is designed to optimize the levels of one or more components in the blood that play a role in preventing or treating a specific condition or disease.

Abstract: An arm for supporting a monitor comprises a telescoping arm assembly, a support member and a cord storage device. The telescoping arm assembly has at least first and second telescoping members telescopingly movable relative to each other, a distal end configured to support a monitor and a hollow interior through which at least one cord from the monitor can be routed. The support member is connected to the telescoping arm assembly proximally of the distal end to suspend the telescoping arm assembly. The support member is configured to extend transverse to the telescoping arm assembly and to be attached to a support surface. The cord storage device is positioned at least partially within at least one of the telescoping arm assembly or the support member. The cord storage device winds and unwinds the cord from the monitor as the first and second telescoping members are moved toward and away from each other, respectively.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications.

Abstract: A prosthetic heart valve assembly comprises a plurality of leaflets configured to replace the function of a native heart valve. Each leaflet comprises laminar pericardium tissue. Each leaflet has a coaptation edge formed by laser cutting. The tissue layers of each leaflet are fused together along an entire length of the coaptation edge, and tissue adjacent each coaptation edge does not have significant thermal energy damage.