Patents by Inventor E. Patrick Groody

E. Patrick Groody has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for the synthesis of oligonucleotides having 5'-phosphorylated termini
    Patent number: 5071974
    Abstract: Methods for the chemical 5' phosphorylation of oligonucleotides. An embodiment of the present invention includes reacting the 5' terminus of an oligonucleotide with a composition represented by the formula: ##STR1## wherein if Y and Z are taken separately, each represent an alkyl, aryl, arylalkyl, cycloalkyl or cycloalkylaryl; or if Y and Z are taken together, Y and Z form an alkyl or alkylene chain with both terminal valence bonds of said chain being attached to the nitrogen atom to which Y and Z are attached; or if Y and Z are taken together, with the nitrogen atom, Y and Z form a nitrogen heterocycle including at least one additional heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur. W and X are selected from the group of functional groups subject to nucleophilic attack or .beta.-elimination and are removed.
    Type: Grant
    Filed: October 31, 1986
    Date of Patent: December 10, 1991
    Assignee: Amoco Corporation
    Inventor: E. Patrick Groody