Patents by Inventor E. Peter Greenberg

E. Peter Greenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metallo-desferrioxamine complexes and their use in the treatment of bacterial infections
    Patent number: 8680148
    Abstract: Methods for treating a bacterial infection by using a metallo-desferrioxamine complex.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: March 25, 2014
    Assignees: University of Washington, Hadasit Medical Research Services and Development Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: E. Peter Greenberg, Ehud Banin, Eyal Banin, Eduard Berenshtein, Mordechai Chevion
  • Methods of inhibiting and treating bacterial biofilms by metal chelators
    Patent number: 8343911
    Abstract: The invention presented herein provides methods and compositions for the prevention and treatment of bacterial infections. The methods are based on the discovery that depletion of bioavailable iron stimulates surface motility in bacteria thus inhibiting the ability of a bacterial population to develop into a biofilm.
    Type: Grant
    Filed: October 20, 2008
    Date of Patent: January 1, 2013
    Assignee: University of Iowa Research Foundation
    Inventors: Pradeep K. Singh, Michael J. Welsh, E. Peter Greenberg
  • Bactobolin analog and synthesis method thereof
    Patent number: 8222434
    Abstract: The present inventions are directed to a novel bactobolin analog bactobolin D. The present inventions also are directed to a method of producing a composition comprising at least one bactobolin analog using a bacteria strain comprising a bacterial cell comprising the biosynthetic locus of the bactobolin analog in Burkholderia thailandensis (bta cluster) or a homolog structure (at least 95% sequence identity) thereof, and further isolation and purification of the bactobolin analog. For example, the bacterial strain can be a wild type bacterial strain such as a Burkholderia strain comprising a bta cluster (e.g. Burkholderia thailandensis (e.g. E264, Bt4, and TXDOH) and Burkholderia pseudomallei (e.g. K96243, 1106a, and 1106b).
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: July 17, 2012
    Assignees: University of Washington through its Center for Commercialization, President and Fellows of Harvard College
    Inventors: E. Peter Greenberg, Josephine R. Chandler, Breck Duerkop, Patricia Silva Lima, Joshua Alan Blodgett, Jon Clardy, Mohammad R. Seyedsayamdost
  • Quorum Sensing Modulators
    Publication number: 20090123512
    Abstract: Compounds described herein are useful in modulating bacterial quorum sensing.
    Type: Application
    Filed: January 20, 2006
    Publication date: May 14, 2009
    Inventors: Ute Muh, Brian Hare, Eric Olson, E. Peter Greenberg
  • Quorum Sensing Modulators
    Publication number: 20080287546
    Abstract: Compounds described herein are useful in modulating bacterial quorum sensing.
    Type: Application
    Filed: January 20, 2006
    Publication date: November 20, 2008
    Inventors: Ute Muh, Brian Hare, Eric Olson, E. Peter Greenberg
  • Quorum sensing signaling in bacteria
    Patent number: 6855513
    Abstract: The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginosa. Novel indicator strains and vectors for engineering the strains for use in the method of the invention are also provided.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: February 15, 2005
    Assignees: University of Iowa Research Foundation, Vertex Pharmaceuticals (San Diego) LLC
    Inventors: Marvin Whiteley, Kimberly M. Lee, E. Peter Greenberg, Ute Muh
  • Autoinducer synthase modulating compounds and uses therefore
    Publication number: 20040152660
    Abstract: Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifying modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.
    Type: Application
    Filed: March 5, 2004
    Publication date: August 5, 2004
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: John E. Cronan, Bryce V. Plapp, E. Peter Greenberg, Matthew R. Parsek
  • Autoinducer synthase modulating compounds and uses thereof
    Patent number: 6723321
    Abstract: Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: April 20, 2004
    Assignees: The Board of Trustees of the University of Illinois, The University of Iowa Research Foundation
    Inventors: E. Peter Greenberg, John E. Cronan, Jr., Bryce V. Plapp, Matthew R. Parsek
  • Quorum sensing signaling in bacteria
    Publication number: 20040033549
    Abstract: The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginosa. Novel indicator strains and vectors for engineering the strains for use in the method of the invention are also provided.
    Type: Application
    Filed: March 14, 2003
    Publication date: February 19, 2004
    Inventors: E. Peter Greenberg, Martin Schuster, Candi Lostroh
  • AUTOINDUCER SYNTHASE MODULATING COMPOUNDS AND USES THEREFORE
    Publication number: 20030054512
    Abstract: Provided are compositions and methods useful for modulating the activity of autoinducer synthase catalysts. A method for identifing modulators of the autoinducer synthesis reaction is also provided. Such modulators are useful for controlling bacterial growth and can be used for therapeutic treatment of bacterial infections particularly in immunocompromised subjects. They are also useful in treating disease states associated with autoinducer synthesis and biofilm development.
    Type: Application
    Filed: January 6, 1999
    Publication date: March 20, 2003
    Applicant: LAHIVE AND COCKFIELD
    Inventors: JOHN E. CRONAN, BRYCE V. PLAPP, E. PETER GREENBERG, MATTHEW R. PARSEK