Patents by Inventor E. Premkumar Reddy

E. Premkumar Reddy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use
    Patent number: 10383831
    Abstract: Compounds according to Formula I are provided: and salts thereof, wherein R1, R2, R3, R4, R5, R6, R13, A, X and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula I.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: August 20, 2019
    Assignee: Temple University—Of The Commonwealth System Of Higher Education
    Inventors: M. V. Ramana Reddy, E. Premkumar Reddy
  • Substituted alkyl diaryl derivatives, methods of preparation and uses
    Patent number: 10207989
    Abstract: Compounds according to Formula I are provided: and salts thereof, wherein Q1, Q2, R3, R4, X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I).
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: February 19, 2019
    Assignee: TEMPLE UNIVERSITY—Of The Commonwealth System of Higher Education
    Inventors: M. V. Ramana Reddy, E. Premkumar Reddy
  • 2,4,6-TRIALKOXYSTRYL ARYL SULFONES, SULFONAMIDES AND CARBOXAMIDES, AND METHODS OF PREPARATION AND USE
    Publication number: 20180243239
    Abstract: Compounds according to Formula I are provided: and salts thereof, wherein R1, R2, R3, R4, R5, R6, R13, A, X and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula I.
    Type: Application
    Filed: August 2, 2016
    Publication date: August 30, 2018
    Inventors: M. V. Ramana Reddy, E. Premkumar Reddy
  • Pyrimidine compounds as kinase inhibitors
    Patent number: 9815847
    Abstract: This disclosure relates to compounds, methods for their preparation, pharmaceutical compositions including these compounds and methods for the treatment of cellular proliferative disorders, including, but not limited to, cancer.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 14, 2017
    Assignee: Icahn School of Medicine at Mount Sinai
    Inventors: M. V. Ramana Reddy, E. Premkumar Reddy
  • PYRIMIDINE COMPOUNDS AS KINASE INHIBITORS
    Publication number: 20160122361
    Abstract: This disclosure relates to compounds, methods for their preparation, pharmaceutical compositions including these compounds and methods for the treatment of cellular proliferative disorders, including, but not limited to, cancer.
    Type: Application
    Filed: March 13, 2014
    Publication date: May 5, 2016
    Inventors: M. V. Ramana REDDY, E. Premkumar REDDY
  • Substituted 2-benzylidene-2H-benzo[b][1,4]thiazin-3(4H)-ones, derivatives thereof, and therapeutic uses thereof
    Patent number: 9242945
    Abstract: The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, Ar, and n are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating cellular proliferative disorders, such as cancer, with the compounds of Formula I.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: January 26, 2016
    Assignee: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES
    Publication number: 20150266819
    Abstract: Compounds according to Formula I are provided: and salts thereof, wherein Q1, Q2, R3, R4, X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided, as well as methods of treating cellular proliferative disorders, such as cancer, using compounds of Formula (I).
    Type: Application
    Filed: September 18, 2013
    Publication date: September 24, 2015
    Inventors: M. V. Ramana Reddy, E. Premkumar Reddy
  • 2-substituted-8-alkyl-7-OXO-7,8-dihydropyrido[2,3-]pyrimidine-6-carbonitriles and uses thereof in treating proliferative disorders
    Patent number: 8987267
    Abstract: Compounds according to Formula (I), as well salts thereof: wherein R1 and R2 are as defined herein, are useful as antiproliferative agents and kinase inhibitors. Synthetic methods for preparing the compounds of Formula (I) are also provided.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: March 24, 2015
    Assignee: Temple University—of the Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • 3-AMINOTHIENO[3,2-c]QUINOLINE DERIVATIVES, METHODS OF PREPARATION AND USES
    Publication number: 20150065499
    Abstract: The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, X, and Y are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating cellular proliferative disorders, such as cancer, with the compounds of Formula I.
    Type: Application
    Filed: February 26, 2013
    Publication date: March 5, 2015
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof
    Patent number: 8889696
    Abstract: Compounds useful as antiproliferative agents according to Formula (I), wherein n, A, R1, R2, and Ar1 are as defined herein, and salts thereof; antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: November 18, 2014
    Assignee: Temple University—Of The Commonwealth System Of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof
    Patent number: 8808702
    Abstract: Compounds useful as antiproliferative agents according to formula (I): wherein Ar1, Ar2, Ar3, m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: August 19, 2014
    Assignee: Temple University-of the Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • KINASE INHIBITORS
    Publication number: 20140142094
    Abstract: This disclosure relates to compounds, methods for their preparation, pharmaceutical compositions including these compounds and methods for the treatment of cellular proliferative disorders, including, but not limited to cancer. The method includes administering to the patient a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 30, 2012
    Publication date: May 22, 2014
    Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: M.V. Ramana Reddy, E. Premkumar Reddy
  • SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF
    Publication number: 20140086941
    Abstract: The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, Ar, and n are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating cellular proliferative disorders, such as cancer, with the compounds of Formula I.
    Type: Application
    Filed: November 26, 2013
    Publication date: March 27, 2014
    Applicants: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
    Patent number: 8664272
    Abstract: Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: March 4, 2014
    Assignees: Temple University—Of the Commonwealth System of Higher Education, Icahn School of Medicine at Mount Sinai
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, James F. Holland, Lewis R. Silverman, Svetlana Zinzar
  • 2-SUBSTITUTED-8-ALKYL-7-OXO-7,8-DIHYDROPYRIDO[2,3-D] PYRIMIDINE-6-CARBONITRILES AND USES THEREOF
    Publication number: 20130131058
    Abstract: Compounds according to Formula (I), as well salts thereof: wherein R1 and R2 are as defined herein, are useful as antiproliferative agents and kinase inhibitors. Synthetic methods for preparing the compounds of Formula (I) are also provided.
    Type: Application
    Filed: July 21, 2011
    Publication date: May 23, 2013
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Treatment of proliferative disorders with amino-substituted (E)-2,6- dialkoxystyryl 4-substituted benzylsulfones
    Patent number: 8324190
    Abstract: Methods of treating cancer using compounds according to Formula (I) are disclosed herein, wherein X, X1, X2, Ra, R1, R2, R3, R4, R5, R6, R7, g, M, y, a, b, d, e, V, W, Z and Q are as defined herein.
    Type: Grant
    Filed: July 14, 2009
    Date of Patent: December 4, 2012
    Assignees: Temple University—Of The Commonwealth System of Higher Education, Onconova Therapeutics, Inc.
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, Stanley C. Bell
  • SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF
    Publication number: 20120269831
    Abstract: Compounds useful as antiproliferative agents according to Formula (I), wherein n, A, R1, R2, and Ar1 are as defined herein, and salts thereof; antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.
    Type: Application
    Filed: December 17, 2010
    Publication date: October 25, 2012
    Applicant: TEMPLE UNIVERSITY- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: E. Premkumar Reddy, M.V. Ramana Reddy
  • Heteroaryl sulfones and sulfonamides and therapeutic uses thereof
    Patent number: 8143428
    Abstract: Compounds of Formula I: wherein R1, R2, M, Q and n are as defined herein, are useful as antiproliferative agents including, for example, as anticancer agents.
    Type: Grant
    Filed: June 8, 2005
    Date of Patent: March 27, 2012
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis
    Patent number: 8143453
    Abstract: ?,?-Unsaturated sulfides, sulfones, sulfoxides and sulfonamides according to Formula I: wherein Ar1, Ar2, X, n, * and R are as defined herein, are prepared by dehydration of ?-hydroxy sulfides, sulfones, sulfoxides or sulfonamides.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: March 27, 2012
    Assignees: Temple University—Of The Commonwealth System of Higher Education, Onconova Therapeutics, Inc.
    Inventors: M. V. Ramana Reddy, E. Premkumar Reddy, Stanley C. Bell
  • Composition and methods for the treatment of proliferative diseases
    Patent number: 8106033
    Abstract: Methods and compositions are provided for treating proliferative disorders, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —OH, —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and an anthracycline, e.g. doxorubicin, or a pharmaceutically acceptable salt thereof, or a platin, e.g. oxaliplatin, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: January 31, 2012
    Assignees: Temple University - Of The Commonwealth System of Higher Education, Mount Sinai School of Medicine
    Inventors: E. Premkumar Reddy, James F. Holland