Abstract: Methods of treating Factor VIIa-associated conditions in a mammal are described, comprising administering to the mammal in need of treatment thereof an effective amount of at least one compound having the formula (I), or a pharmaceutically-acceptable salt, hydrate or prodrug thereof.

Abstract: The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel 3,4-disubstituted benzamidines and benzylamines, or a stereoisomer or pharmaceutically acceptable salt form thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor Xa, factor XIa, factor IXa, and/or factor VIIa. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

Abstract: An aerial work platform supported by a riser boom, a telescoping main boom, and a jib boom. Boom movement may be controlled by a platform control module or a ground control module connected to a controller by a controller area network (CAN). Movement of the platform and the jib boom are limited to a predefined envelope. If an operator attempts to move the platform outside the envelope, the controller automatically retracts the telescoping boom section or automatically levels the jib boom section in order to maintain the platform within the acceptable envelope. Boom section select switches permit the operator to select and move sequentially or simultaneously in different directions. Timers which are part of the system include various interlocks to accomplish safety and power saver features.