Abstract: Implantable medical electrical leads having electrodes arranged such that a defibrillation coil electrode and a pace/sense electrode(s) are concurrently positioned substantially over the ventricle when implanted as described. The leads include an elongated lead body having a distal portion and a proximal end, a connector at the proximal end of the lead body, a defibrillation electrode located along the distal portion of the lead body, wherein the defibrillation electrode includes a first electrode segment and a second electrode segment proximal to the first electrode segment by a distance. The leads may include at least one pace/sense electrode, which in some instances, is located between the first defibrillation electrode segment and the second defibrillation electrode segment.

Abstract: The application includes systems and methods for phenotyping. A request is received to identify a target population having a phenotype. Predefined characteristics associated with the phenotype are obtained. Using a retriever model, a set of subjects is identified as potential members of the target population by searching databases. Medical information is obtained by searching a second set of one or more databases and providing corresponding information to an artificial intelligence (AI) component. Natural language instructions are provided to the AI component to provide context to the AI component to determine whether a respective subject in the set of subjects has at least one of the one or more predefined characteristics. A subset of subjects is identified by the AI system to be, or to have a high likelihood of being, a member of the target population.

Abstract: An apparatus for controlling the printing on wire or cable. The apparatus including a processor, a bus connected to the processor, a user input connected to the bus, a display screen connected to the user input and the bus, a first storage system connected to the bus, data stored in the first storage system and displayable on the display screen, wherein the data includes manufacturing and print information, a printer connected to the bus, wherein the printer prints the data on the wire or cable, a communication device connected to the bus, and an identification device connected to the bus, wherein identification device receives information from a user.

Abstract: In some examples, a medical device includes an elongated structure configured to extend from an access point of a patient through an intercostal space within the patient. The medical device may further include a plurality of electrodes comprising a first subset of electrodes and a second subset of electrodes, where at least the first subset of electrodes is carried on a distal portion of the elongated structure. The first subset of electrodes of the plurality of electrodes may be configured to deliver electrical therapy to a heart of the patient or sense cardiac activity. The second subset of electrodes of the plurality of electrodes may be configured to deliver energy to tissue proximate a ribcage of the patient to reduce a sensation in one or more intercostal nerves.

Abstract: This disclosure describes implantable medical leads and medical device systems utilizing the leads. In some examples, an implantable medical lead comprises a first defibrillation electrode and a second defibrillation electrode, the first and second defibrillation electrodes configured to deliver anti-tachyarrhythmia shocks, and a pace electrode disposed between the first defibrillation electrode and the second defibrillation electrode, the pace electrode configured to deliver a pacing pulse that generates an electric field proximate to the pace electrode. The implantable medical lead further comprises a shield disposed between the first defibrillation electrode and the second defibrillation electrode and over a portion of an outer surface of the pace electrode, wherein the shield is configured to impede the electric field in a direction from the pace electrode away from a heart.

Abstract: Provided are compounds comprising at least one ligand LA, represented by Formula I wherein at least one of RA and RB comprises a substituent capable of thermally activated delayed fluorescence, a ?-deficient heterocycle, or a trisubstituted boron atom. Also provided are formulations comprising these compounds. Further provided are OLEDs and related consumer products that utilize these compounds.

Abstract: Methods of forming a fertilizer composition having slow-release nitrogen compounds with a molten process are disclosed. The methods include mixing of a crystalline polyethylene wax with urea and formaldehyde to form a molten methylene urea mixture. The contents of the molten methylene urea mixture react to form slow-release nitrogen compounds. Fertilizer compositions formed of or including the slow-release nitrogen compounds are also disclosed.

Abstract: A compound selected from the group consisting of Formula I, Formula II, and Formula III, wherein ring A, ring B, and ring C are independently a five-membered or six-membered, carbocyclic or heterocyclic ring, each of which is optionally aromatic; ring W of Formula I is a 6-membered heterocyclic ring, and ring W of Formula II or Formula III is a 5-membered or 6-membered heterocyclic ring; L is a monodentate ligand with a metal coordinating member selected from the group consisting of C, N, O, S, and P; and M is a metal selected from the group consisting of Cu, Au, and Ag.

Abstract: Extravascular implant tools that utilize a bore-in mechanism to safely access extravascular locations and implant techniques utilizing these tools are described. The bore-in mechanism may include a handle and a helix extending from the handle. The bore-in mechanism is used, for example, in conjunction with a tunneling tool to traverse the diaphragmatic attachments to access a substernal location. The tunneling tool may be an open channel tunneling tool or a conventional tunneling tool (e.g., metal rod).

Abstract: Provided are compounds of Formula I wherein at least one of RA, RB, RC, and RD represents a group of Formula A. Also provided are formulations comprising these compounds. Further provided are OLEDs and related consumer products that utilize these compounds.

Abstract: An implantable cardioverter defibrillator (ICD) receives a cardiac electrical signal by a sensing circuit while operating in a sensing without pacing mode and detects asystole based on the cardiac electrical signal. The ICD determines, in response to detecting the asystole, if asystole backup pacing is enabled, and automatically switches to a temporary pacing mode in response to the asystole backup pacing being enabled. Other examples of detecting asystole and providing a response to detecting asystole by the ICD are described herein.

Abstract: A medical device is configured to deliver therapeutic electrical stimulation pulses by generating frequency modulated electrical stimulation pulse signals. The medical device includes a pulse signal source and a modulator. The pulse signal source generates an electrical stimulation pulse signal having a pulse width. The modulator may include a high frequency modulator configured to modulate a frequency of the pulse signal from a starting frequency down to a minimum frequency during the pulse width. The modulator may include a low frequency bias generator to modulate the offset of the pulse signal between a minimum offset and a maximum offset in other examples.

Abstract: Methods for predicting health characteristic may include: obtaining patient medical information that includes protein data; a machine-learning model based on concordance with the characteristic, the patient medical information, a time-frame for prediction, or in the protein data. Different models may have been trained using different groupings of training patient data, trained to predict different characteristics, trained or evaluated using different biomarkers, trained using proteins, protein groups, or protein categories listed in Tables M through R, or evaluated for different time-frames. The selected model may be used to generate the prediction using the patient medical information. A model may be generated by pre-processing medical information, generating an ensemble of models; determining a sensitivity of variables of the medical information to identify a subset of variables; and training a machine-learning model using the subset.

Abstract: An extra-cardiovascular implantable cardioverter defibrillator (ICD) having a low voltage therapy module and a high voltage therapy module is configured to select, by a control module of the ICD, a pacing output configuration from at least a low-voltage pacing output configuration of the low voltage therapy module and a high-voltage pacing output configuration of the high voltage therapy module. The high voltage therapy module includes a high voltage capacitor having a first capacitance and the low voltage therapy module includes a plurality of low voltage capacitors each having up to a second capacitance that is less than the first capacitance. The ICD control module controls a respective one of the low voltage therapy module or the high voltage therapy module to deliver extra-cardiovascular pacing pulses in the selected pacing output configuration via extra-cardiovascular electrodes coupled to the ICD.

Abstract: A pool return fitting having a housing with a first chamber and second chamber. The second chamber is retained within the first chamber. The first chamber has a first pipe connection configured to receive a fluid. The first chamber has a first opening bordering a third chamber of an integrally formed support structure. The second chamber has a second pipe connection configured to receive a conduit. The second chamber has a second opening configured to retain a submersible light fixture. A transparent lens is connected to the integrally formed support structure and has opening. Fluid flows from the first opening of first chamber into a third chamber of the integrally formed support structure, over a lens of the submersible light fixture retained by the second chamber, and through an opening of the transparent lens to be expelled from the third chamber into the surrounding fluid external of the housing.

Abstract: A lead body having a defibrillation electrode positioned along a distal portion of the lead body is described. The defibrillation electrode includes a plurality of electrode segments spaced a distance apart from each other. At least one of the plurality of defibrillation electrode segments includes at least one coated portion and at least one uncoated portion. The at least one coated portion is coated with an electrically insulating material configured to prevent transmission of a low voltage signal (e.g., a pacing pulse) while allowing transmission of a high voltage signal (e.g., a cardioversion defibrillation shock). The at least one uncoated portion is configured to transmit both low voltage and high voltage signals. The lead may also include one or more discrete electrodes proximal, distal or between the defibrillation electrode segments.

Abstract: An extra-cardiovascular medical device is configured to select a capacitor configuration from a capacitor array and deliver a low voltage, pacing pulse by discharging the selected capacitor configuration across an extra-cardiovascular pacing electrode vector. In some examples, the medical device is configured to determine the capacitor configuration based on a measured impedance of the extra-cardiovascular pacing electrode vector.

Abstract: Organic light emitting devices incorporating a film of metal complex emitters that are oriented with their transition dipole moment vectors oriented parallel to the device substrate enhances the outcoupling and eliminate the need for micro-lens arrays, gratings, or other physical extraneous outcoupling methods.

Abstract: Implantable medical electrical leads having electrodes arranged such that a defibrillation coil electrode and a pace/sense electrode(s) are concurrently positioned substantially over the ventricle when implanted as described. The leads include an elongated lead body having a distal portion and a proximal end, a connector at the proximal end of the lead body, a defibrillation electrode located along the distal portion of the lead body, wherein the defibrillation electrode includes a first electrode segment and a second electrode segment proximal to the first electrode segment by a distance. The leads may include at least one pace/sense electrode, which in some instances, is located between the first defibrillation electrode segment and the second defibrillation electrode segment.

Abstract: Provided are organometallic compounds comprising as metal at least one of the coin metals Au, Ag, and Cu and further a ligand comprising a 5-membered heterocyclic ring which is fused to a 6-membered aromatic ring and also fused to a 5- or 6-membered carbocyclic or heterocyclic ring or fused ring system. Also provided are formulations comprising these organometallic compounds. Further provided are organic light emitting devices (OLEDs) and related consumer products that utilize these organometallic compounds.