Patents by Inventor Eamon Comer
Eamon Comer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250051338Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. Compounds and compositions thereof that are useful, for example, for targeting, inhibiting, and/or degrading TYK2. In certain embodiments, provided are TYK2 inhibitors and/or degraders and methods of making same. More specifically, TYK2 degraders, compositions which comprise TYK2 degraders, and methods of treating TYK2-associated conditions are provided.Type: ApplicationFiled: October 24, 2022Publication date: February 13, 2025Inventors: Isaac MARX, Christopher M. YATES, Xiao ZHU, Lewis Dale PENNINGTON, Eamon COMER, Melissa FORD
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Publication number: 20240173419Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.Type: ApplicationFiled: August 21, 2023Publication date: May 30, 2024Inventors: Philip COLLIER, Xiaozhang ZHENG, Xiao ZHU, Melissa FORD, Matthew M. WEISS, Robert AVERSA, Lewis Dale PENNINGTON, Eamon COMER, Kiran Vijayakumari MAHASENAN, Yi ZHANG
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Patent number: 11866441Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.Type: GrantFiled: July 28, 2021Date of Patent: January 9, 2024Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Eamon Comer, Nobutaka Kato, Marshall Morningstar, Bruno Melillo
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Publication number: 20230279018Abstract: The invention provides agents that inhibit L-Phe in cytoplasmic phenylalanine tRNA-synthetase (cFRS), methods for identifying them, compositions comprising such agents, and therapeutic methods of using such agents.Type: ApplicationFiled: March 22, 2023Publication date: September 7, 2023Applicants: The Broad Institute, Inc., President and Fellows of Harvard College, Eisai R&D Management Co., LTD.Inventors: Eamon COMER, Bruno MELILLO, Francis G. FANG, Branko MITASEV
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Publication number: 20230009323Abstract: Cryptosporidium is a leading contributor to early childhood mortality, and fully effective treatment for this important infectious disease is lacking. A bicyclic azetidine compound series is disclosed having potent in vitro activity against all C. parvum isolates tested, comparable potencies against C. hominis and C. parvum, and cured cryptosporidiosis in highly susceptible immunosuppressed mice with once-daily dosing.Type: ApplicationFiled: October 23, 2020Publication date: January 12, 2023Applicants: The Broad Institute, Inc., President and Fellows of Harvard College, The University of Vermont and State Agriculture CollegeInventors: Eamon COMER, Bruno MELILLO, Christopher D. HUSTON
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Publication number: 20220193034Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including cryptosporidiosis.Type: ApplicationFiled: April 22, 2020Publication date: June 23, 2022Applicants: WASHINGTON UNIVERSITY, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Laurence David Sibley, Bruno Melillo, Eamon Comer
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Publication number: 20220162211Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.Type: ApplicationFiled: July 28, 2021Publication date: May 26, 2022Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: EAMON COMER, NOBUTAKA KATO, MARSHALL MORNINGSTAR, BRUNO MELILLO
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Publication number: 20220144812Abstract: The present disclosure provides novel compounds, compositions comprising the compounds and methods of use thereof.Type: ApplicationFiled: March 27, 2020Publication date: May 12, 2022Applicant: Epizyme, Inc.Inventors: Eamon Comer, Kenneth W. Duncan, Alexis Cocozaki, John Campbell, Darren Harvey, Michael Munchhof
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Patent number: 11325913Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.Type: GrantFiled: June 29, 2020Date of Patent: May 10, 2022Assignee: THE BROAD INSTITUTE, INC.Inventors: Eamon Comer, Nobutaka Kato, Christina Scherer, Jessica Bastien, Jeremy Duvall, Timothy Lewis, Morgane Sayes, Matthew Leighty, Jun Pu, Jennifer Beaudoin, Bertrand Braibant, Benito Munoz
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Publication number: 20220033404Abstract: Provided herein are compounds useful for the treatment of diseases caused by infections of T. gondii, and closely related parasites. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions including veterinary compositions and may be used in methods of treatment and/or prophylaxis of disease.Type: ApplicationFiled: September 18, 2019Publication date: February 3, 2022Applicants: WASHINGTON UNIVERSITY, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: L. DAVID SIBLEY, JOSHUA RADKE, EAMON COMER, MARSHALL MORNINGSTAR, BRUNO MELILLO
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Patent number: 11174260Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.Type: GrantFiled: March 20, 2018Date of Patent: November 16, 2021Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Eamon Comer, Nobutaka Kato, Marshall Morningstar, Bruno Melillo
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Publication number: 20200399276Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.Type: ApplicationFiled: June 29, 2020Publication date: December 24, 2020Applicant: THE BROAD INSTITUTE, INC.Inventors: EAMON COMER, NOBUTAKA KATO, CHRISTINA SCHERER, JESSICA BASTIEN, JEREMY DUVALL, TIMOTHY LEWIS, MORGANE SAYES, MATTHEW LEIGHTY, JUN PU, JENNIFER BEAUDOIN, BERTRAND BRAIBANT, BENITO MUNOZ
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Patent number: 10738055Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.Type: GrantFiled: July 23, 2018Date of Patent: August 11, 2020Assignee: The Broad Institute, Inc.Inventors: Eamon Comer, Nobutaka Kato, Christina Scherer, Jessica Bastien, Jeremy Duvall, Timothy Lewis, Morgane Sayes, Matthew Leighty, Jun Pu, Jennifer Beaudoin, Bertrand Braibant, Benito Munoz
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Publication number: 20200095253Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.Type: ApplicationFiled: March 20, 2018Publication date: March 26, 2020Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: EAMON COMER, NOBUTAKA KATO, MARSHALL MORNINGSTAR, BRUNO MELILLO
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Publication number: 20190055252Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.Type: ApplicationFiled: July 23, 2018Publication date: February 21, 2019Applicant: THE BROAD INSTITUTE, INC.Inventors: EAMON COMER, NOBUTAKA KATO, CHRISTINA SCHERER, JESSICA BASTIEN, JEREMY DUVALL, TIMOTHY LEWIS, MORGANE SAYES, MATTHEW LEIGHTY, JUN PU, JENNIFER BEAUDOIN, BERTRAND BRAIBANT, BENITO MUNOZ
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Patent number: 10059711Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.Type: GrantFiled: November 11, 2014Date of Patent: August 28, 2018Assignee: The Broad Institute, Inc.Inventors: Eamon Comer, Nobutaka Kato, Christina Scherer, Jessica Bastien, Jeremy Duvall, Timothy Lewis, Morgane Sayes, Matthew Leighty, Jun Pu, Jennifer Beaudoin, Bertrand Braibant, Benito Munoz
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Patent number: 9526720Abstract: The present invention relates to compounds that are useful for modulating hepatic cholesterol metabolism in an animal. The invention includes methods of making and using the compounds of the invention. The invention further provides methods of treating, preventing and/or alleviating a cholesterol related disorder, a cardiovascular disease and/or liver disease in an animal, such as a human, comprising administering compounds of the invention, or pharmaceutically acceptable salts or solvates thereof, to the animal.Type: GrantFiled: August 19, 2013Date of Patent: December 27, 2016Assignee: The Broad Institute, Inc.Inventors: Marek Maria Nagiec, Jose R. Perez, Michelle Palmer, Adam Skepner, Eamon Comer
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Publication number: 20160289235Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.Type: ApplicationFiled: November 11, 2014Publication date: October 6, 2016Applicant: THE BROAD INSTITUTE, INC.Inventors: EAMON COMER, NOBUTAKA KATO, CHRISTINA SCHERER, JESSICA BASTIEN, JEREMY DUVALL, TIMOTHY LEWIS, MORGANE SAYES, MATTHEW LEIGHTY, JUN PU, JENNIFER BEAUDOIN, BERTRAND BRAIBANT, BENITO MUNOZ
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Patent number: 9428507Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.Type: GrantFiled: June 20, 2014Date of Patent: August 30, 2016Assignees: The Broad Institute, Inc., President and Fellows of Harvard CollegeInventors: Eamon Comer, Benito Munoz, Jennifer A. Beaudoin, Sebastian T. Le Quement, Christina Scherer, Jeremy Duvall, Nobutaka Kato, Micah Maetani, Bertrand Braibant
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Publication number: 20160152617Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.Type: ApplicationFiled: June 20, 2014Publication date: June 2, 2016Inventors: Eamon COMER, Benito MUNOZ, Jennifer A. BEAUDOIN, Sebastian T. LE QUEMENT, Christina SCHERER, Jeremy DUVALL, Nobutaka KATO, Micah MAETANI, Bertrand BRAIBANT
