Patents by Inventor Eamon Comer

Eamon Comer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250051338
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. Compounds and compositions thereof that are useful, for example, for targeting, inhibiting, and/or degrading TYK2. In certain embodiments, provided are TYK2 inhibitors and/or degraders and methods of making same. More specifically, TYK2 degraders, compositions which comprise TYK2 degraders, and methods of treating TYK2-associated conditions are provided.
    Type: Application
    Filed: October 24, 2022
    Publication date: February 13, 2025
    Inventors: Isaac MARX, Christopher M. YATES, Xiao ZHU, Lewis Dale PENNINGTON, Eamon COMER, Melissa FORD
  • Publication number: 20240173419
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: August 21, 2023
    Publication date: May 30, 2024
    Inventors: Philip COLLIER, Xiaozhang ZHENG, Xiao ZHU, Melissa FORD, Matthew M. WEISS, Robert AVERSA, Lewis Dale PENNINGTON, Eamon COMER, Kiran Vijayakumari MAHASENAN, Yi ZHANG
  • Patent number: 11866441
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: January 9, 2024
    Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Eamon Comer, Nobutaka Kato, Marshall Morningstar, Bruno Melillo
  • Publication number: 20230279018
    Abstract: The invention provides agents that inhibit L-Phe in cytoplasmic phenylalanine tRNA-synthetase (cFRS), methods for identifying them, compositions comprising such agents, and therapeutic methods of using such agents.
    Type: Application
    Filed: March 22, 2023
    Publication date: September 7, 2023
    Applicants: The Broad Institute, Inc., President and Fellows of Harvard College, Eisai R&D Management Co., LTD.
    Inventors: Eamon COMER, Bruno MELILLO, Francis G. FANG, Branko MITASEV
  • Publication number: 20230009323
    Abstract: Cryptosporidium is a leading contributor to early childhood mortality, and fully effective treatment for this important infectious disease is lacking. A bicyclic azetidine compound series is disclosed having potent in vitro activity against all C. parvum isolates tested, comparable potencies against C. hominis and C. parvum, and cured cryptosporidiosis in highly susceptible immunosuppressed mice with once-daily dosing.
    Type: Application
    Filed: October 23, 2020
    Publication date: January 12, 2023
    Applicants: The Broad Institute, Inc., President and Fellows of Harvard College, The University of Vermont and State Agriculture College
    Inventors: Eamon COMER, Bruno MELILLO, Christopher D. HUSTON
  • Publication number: 20220193034
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including cryptosporidiosis.
    Type: Application
    Filed: April 22, 2020
    Publication date: June 23, 2022
    Applicants: WASHINGTON UNIVERSITY, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Laurence David Sibley, Bruno Melillo, Eamon Comer
  • Publication number: 20220162211
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.
    Type: Application
    Filed: July 28, 2021
    Publication date: May 26, 2022
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: EAMON COMER, NOBUTAKA KATO, MARSHALL MORNINGSTAR, BRUNO MELILLO
  • Publication number: 20220144812
    Abstract: The present disclosure provides novel compounds, compositions comprising the compounds and methods of use thereof.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 12, 2022
    Applicant: Epizyme, Inc.
    Inventors: Eamon Comer, Kenneth W. Duncan, Alexis Cocozaki, John Campbell, Darren Harvey, Michael Munchhof
  • Patent number: 11325913
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: May 10, 2022
    Assignee: THE BROAD INSTITUTE, INC.
    Inventors: Eamon Comer, Nobutaka Kato, Christina Scherer, Jessica Bastien, Jeremy Duvall, Timothy Lewis, Morgane Sayes, Matthew Leighty, Jun Pu, Jennifer Beaudoin, Bertrand Braibant, Benito Munoz
  • Publication number: 20220033404
    Abstract: Provided herein are compounds useful for the treatment of diseases caused by infections of T. gondii, and closely related parasites. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions including veterinary compositions and may be used in methods of treatment and/or prophylaxis of disease.
    Type: Application
    Filed: September 18, 2019
    Publication date: February 3, 2022
    Applicants: WASHINGTON UNIVERSITY, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: L. DAVID SIBLEY, JOSHUA RADKE, EAMON COMER, MARSHALL MORNINGSTAR, BRUNO MELILLO
  • Patent number: 11174260
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: November 16, 2021
    Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Eamon Comer, Nobutaka Kato, Marshall Morningstar, Bruno Melillo
  • Publication number: 20200399276
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Application
    Filed: June 29, 2020
    Publication date: December 24, 2020
    Applicant: THE BROAD INSTITUTE, INC.
    Inventors: EAMON COMER, NOBUTAKA KATO, CHRISTINA SCHERER, JESSICA BASTIEN, JEREMY DUVALL, TIMOTHY LEWIS, MORGANE SAYES, MATTHEW LEIGHTY, JUN PU, JENNIFER BEAUDOIN, BERTRAND BRAIBANT, BENITO MUNOZ
  • Patent number: 10738055
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 11, 2020
    Assignee: The Broad Institute, Inc.
    Inventors: Eamon Comer, Nobutaka Kato, Christina Scherer, Jessica Bastien, Jeremy Duvall, Timothy Lewis, Morgane Sayes, Matthew Leighty, Jun Pu, Jennifer Beaudoin, Bertrand Braibant, Benito Munoz
  • Publication number: 20200095253
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.
    Type: Application
    Filed: March 20, 2018
    Publication date: March 26, 2020
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: EAMON COMER, NOBUTAKA KATO, MARSHALL MORNINGSTAR, BRUNO MELILLO
  • Publication number: 20190055252
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Application
    Filed: July 23, 2018
    Publication date: February 21, 2019
    Applicant: THE BROAD INSTITUTE, INC.
    Inventors: EAMON COMER, NOBUTAKA KATO, CHRISTINA SCHERER, JESSICA BASTIEN, JEREMY DUVALL, TIMOTHY LEWIS, MORGANE SAYES, MATTHEW LEIGHTY, JUN PU, JENNIFER BEAUDOIN, BERTRAND BRAIBANT, BENITO MUNOZ
  • Patent number: 10059711
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: August 28, 2018
    Assignee: The Broad Institute, Inc.
    Inventors: Eamon Comer, Nobutaka Kato, Christina Scherer, Jessica Bastien, Jeremy Duvall, Timothy Lewis, Morgane Sayes, Matthew Leighty, Jun Pu, Jennifer Beaudoin, Bertrand Braibant, Benito Munoz
  • Patent number: 9526720
    Abstract: The present invention relates to compounds that are useful for modulating hepatic cholesterol metabolism in an animal. The invention includes methods of making and using the compounds of the invention. The invention further provides methods of treating, preventing and/or alleviating a cholesterol related disorder, a cardiovascular disease and/or liver disease in an animal, such as a human, comprising administering compounds of the invention, or pharmaceutically acceptable salts or solvates thereof, to the animal.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: December 27, 2016
    Assignee: The Broad Institute, Inc.
    Inventors: Marek Maria Nagiec, Jose R. Perez, Michelle Palmer, Adam Skepner, Eamon Comer
  • Publication number: 20160289235
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Application
    Filed: November 11, 2014
    Publication date: October 6, 2016
    Applicant: THE BROAD INSTITUTE, INC.
    Inventors: EAMON COMER, NOBUTAKA KATO, CHRISTINA SCHERER, JESSICA BASTIEN, JEREMY DUVALL, TIMOTHY LEWIS, MORGANE SAYES, MATTHEW LEIGHTY, JUN PU, JENNIFER BEAUDOIN, BERTRAND BRAIBANT, BENITO MUNOZ
  • Patent number: 9428507
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: August 30, 2016
    Assignees: The Broad Institute, Inc., President and Fellows of Harvard College
    Inventors: Eamon Comer, Benito Munoz, Jennifer A. Beaudoin, Sebastian T. Le Quement, Christina Scherer, Jeremy Duvall, Nobutaka Kato, Micah Maetani, Bertrand Braibant
  • Publication number: 20160152617
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Application
    Filed: June 20, 2014
    Publication date: June 2, 2016
    Inventors: Eamon COMER, Benito MUNOZ, Jennifer A. BEAUDOIN, Sebastian T. LE QUEMENT, Christina SCHERER, Jeremy DUVALL, Nobutaka KATO, Micah MAETANI, Bertrand BRAIBANT