Patents by Inventor Eamon Comer

Eamon Comer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TYK2 DEGRADERS AND USES THEREOF
    Publication number: 20260125400
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: April 19, 2024
    Publication date: May 7, 2026
    Inventors: Isaac Marx, Xiao Zhu, Christopher M. Yates, Bin Yang, Xiaozhang Zheng, Michael D. Sintchak, Yi Zhang, Matthew M. Weiss, Lewis Dale Pennington, Nan Ji, Eamon Comer, Melissa Ford
  • Treatment of infections of toxoplasma gondii and closely related parasites
    Patent number: 12600727
    Abstract: Provided herein are compounds useful for the treatment of diseases caused by infections of T. gondii, and closely related parasites. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions including veterinary compositions and may be used in methods of treatment and/or prophylaxis of disease.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: April 14, 2026
    Assignees: WASHINGTON UNIVERSITY, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: L. David Sibley, Joshua Radke, Eamon Comer, Marshall Morningstar, Bruno Melillo
  • BCL-XL/BCL-2 DEGRADERS AND USES THEREOF
    Publication number: 20260092057
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 12, 2023
    Publication date: April 2, 2026
    Inventors: Huijun Dong, Bin Yang, Lewis Dale Pennington, Eamon Comer, Melissa Ford, Robert Aversa, Matthew M. Weiss, Xiao Zhu, Thijs Beuming
  • STAT6 DEGRADERS AND USES THEREOF
    Publication number: 20260092078
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: September 18, 2023
    Publication date: April 2, 2026
    Inventors: Bin Yang, Bruce C. Follows, Huijun Dong, Lewis Dale Pennington, Eamon Comer, Melissa Ford
  • STAT DEGRADERS AND USES THEREOF
    Publication number: 20250375460
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: June 22, 2023
    Publication date: December 11, 2025
    Inventors: Bin Yang, Lewis Dale Pennington, Eamon Comer, Melissa Ford
  • Compounds and methods for the treatment of parasitic diseases
    Patent number: 12414935
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including cryptosporidiosis.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: September 16, 2025
    Assignees: Washington University, The Broad Institute, Inc., President and Fellows of Harvard College
    Inventors: Laurence David Sibley, Bruno Melillo, Eamon Comer
  • TYK2 DEGRADERS AND USES THEREOF
    Publication number: 20250051338
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. Compounds and compositions thereof that are useful, for example, for targeting, inhibiting, and/or degrading TYK2. In certain embodiments, provided are TYK2 inhibitors and/or degraders and methods of making same. More specifically, TYK2 degraders, compositions which comprise TYK2 degraders, and methods of treating TYK2-associated conditions are provided.
    Type: Application
    Filed: October 24, 2022
    Publication date: February 13, 2025
    Inventors: Isaac MARX, Christopher M. YATES, Xiao ZHU, Lewis Dale PENNINGTON, Eamon COMER, Melissa FORD
  • CDK2 DEGRADERS AND USES THEREOF
    Publication number: 20240173419
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: August 21, 2023
    Publication date: May 30, 2024
    Inventors: Philip COLLIER, Xiaozhang ZHENG, Xiao ZHU, Melissa FORD, Matthew M. WEISS, Robert AVERSA, Lewis Dale PENNINGTON, Eamon COMER, Kiran Vijayakumari MAHASENAN, Yi ZHANG
  • Compounds and methods for the treatment of parasitic diseases
    Patent number: 11866441
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: January 9, 2024
    Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Eamon Comer, Nobutaka Kato, Marshall Morningstar, Bruno Melillo
  • APICOMPLEXAN PARASITE INHIBITION
    Publication number: 20230279018
    Abstract: The invention provides agents that inhibit L-Phe in cytoplasmic phenylalanine tRNA-synthetase (cFRS), methods for identifying them, compositions comprising such agents, and therapeutic methods of using such agents.
    Type: Application
    Filed: March 22, 2023
    Publication date: September 7, 2023
    Applicants: The Broad Institute, Inc., President and Fellows of Harvard College, Eisai R&D Management Co., LTD.
    Inventors: Eamon COMER, Bruno MELILLO, Francis G. FANG, Branko MITASEV
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF CRYPTOSPORIDIOSIS
    Publication number: 20230009323
    Abstract: Cryptosporidium is a leading contributor to early childhood mortality, and fully effective treatment for this important infectious disease is lacking. A bicyclic azetidine compound series is disclosed having potent in vitro activity against all C. parvum isolates tested, comparable potencies against C. hominis and C. parvum, and cured cryptosporidiosis in highly susceptible immunosuppressed mice with once-daily dosing.
    Type: Application
    Filed: October 23, 2020
    Publication date: January 12, 2023
    Applicants: The Broad Institute, Inc., President and Fellows of Harvard College, The University of Vermont and State Agriculture College
    Inventors: Eamon COMER, Bruno MELILLO, Christopher D. HUSTON
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF PARASITIC DISEASES
    Publication number: 20220193034
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including cryptosporidiosis.
    Type: Application
    Filed: April 22, 2020
    Publication date: June 23, 2022
    Applicants: WASHINGTON UNIVERSITY, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Laurence David Sibley, Bruno Melillo, Eamon Comer
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF PARASITIC DISEASES
    Publication number: 20220162211
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.
    Type: Application
    Filed: July 28, 2021
    Publication date: May 26, 2022
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: EAMON COMER, NOBUTAKA KATO, MARSHALL MORNINGSTAR, BRUNO MELILLO
  • QUINOLINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER
    Publication number: 20220144812
    Abstract: The present disclosure provides novel compounds, compositions comprising the compounds and methods of use thereof.
    Type: Application
    Filed: March 27, 2020
    Publication date: May 12, 2022
    Applicant: Epizyme, Inc.
    Inventors: Eamon Comer, Kenneth W. Duncan, Alexis Cocozaki, John Campbell, Darren Harvey, Michael Munchhof
  • Compounds and methods for the treatment of malaria
    Patent number: 11325913
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: May 10, 2022
    Assignee: THE BROAD INSTITUTE, INC.
    Inventors: Eamon Comer, Nobutaka Kato, Christina Scherer, Jessica Bastien, Jeremy Duvall, Timothy Lewis, Morgane Sayes, Matthew Leighty, Jun Pu, Jennifer Beaudoin, Bertrand Braibant, Benito Munoz
  • TREATMENT OF INFECTIONS OF TOXOPLASMA GONDII AND CLOSELY RELATED PARASITES
    Publication number: 20220033404
    Abstract: Provided herein are compounds useful for the treatment of diseases caused by infections of T. gondii, and closely related parasites. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions including veterinary compositions and may be used in methods of treatment and/or prophylaxis of disease.
    Type: Application
    Filed: September 18, 2019
    Publication date: February 3, 2022
    Applicants: WASHINGTON UNIVERSITY, THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: L. DAVID SIBLEY, JOSHUA RADKE, EAMON COMER, MARSHALL MORNINGSTAR, BRUNO MELILLO
  • Compounds and methods for the treatment of parasitic diseases
    Patent number: 11174260
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: November 16, 2021
    Assignees: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Eamon Comer, Nobutaka Kato, Marshall Morningstar, Bruno Melillo
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA
    Publication number: 20200399276
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Application
    Filed: June 29, 2020
    Publication date: December 24, 2020
    Applicant: THE BROAD INSTITUTE, INC.
    Inventors: EAMON COMER, NOBUTAKA KATO, CHRISTINA SCHERER, JESSICA BASTIEN, JEREMY DUVALL, TIMOTHY LEWIS, MORGANE SAYES, MATTHEW LEIGHTY, JUN PU, JENNIFER BEAUDOIN, BERTRAND BRAIBANT, BENITO MUNOZ
  • Compounds and methods for the treatment of malaria
    Patent number: 10738055
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 11, 2020
    Assignee: The Broad Institute, Inc.
    Inventors: Eamon Comer, Nobutaka Kato, Christina Scherer, Jessica Bastien, Jeremy Duvall, Timothy Lewis, Morgane Sayes, Matthew Leighty, Jun Pu, Jennifer Beaudoin, Bertrand Braibant, Benito Munoz
  • COMPOUNDS AND METHODS FOR THE TREATMENT OF PARASITIC DISEASES
    Publication number: 20200095253
    Abstract: Provided herein are compounds useful for the treatment of various parasitic diseases. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compostions, veterinary compositions and may be used in methods of treatment and/or prophylaxis of diseases spread by parasites, including malaria and cryptosporidiosis.
    Type: Application
    Filed: March 20, 2018
    Publication date: March 26, 2020
    Applicants: THE BROAD INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: EAMON COMER, NOBUTAKA KATO, MARSHALL MORNINGSTAR, BRUNO MELILLO