Patents by Inventor Eamonn Connolly

Eamonn Connolly has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160287702
    Abstract: A method of improving immune-function in mammals using selected 3-HPA producing lactic acid bacteria with a medium chain triglyceride (MCT) oil.
    Type: Application
    Filed: March 7, 2016
    Publication date: October 6, 2016
    Inventors: Ho-Jin Kang, Eamonn Connolly
  • Patent number: 9340840
    Abstract: The invention herein provides certain strains of lactic acid bacteria selected for their capability of promoting production of IL-10 and consequently proliferation of CD4+CD25+ TR cells, for prophylaxis and/or treatment of infant colic, a method of selecting such strains, and products containing such strains.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: May 17, 2016
    Assignee: Biogaia AB
    Inventors: Eamonn Connolly, Bo Mollstam
  • Publication number: 20150231186
    Abstract: A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the GI tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein said method comprises: a) a step of spatiotemporal (ST) mapping carried out on a gastrointestinal segment to analyse the effect of said agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyse the effect of said agent on mesenteric afferent nerve firing. Bacterial strains selected by the methods of the invention and the use of said bacterial strains in the treatment of intestinal motility disorders are also provided.
    Type: Application
    Filed: September 3, 2013
    Publication date: August 20, 2015
    Inventors: Eamonn Connolly, Wolfgang Kunze, John Bienenstock
  • Patent number: 9057112
    Abstract: The invention herein provides certain strains of lactic acid bacteria selected for their capability of promoting production of IL-10 and consequently proliferation of CD4+CD25+ TR cells, for prophylaxis and/or treatment of infant colic, a method of selecting such strains, and products containing such strains.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: June 16, 2015
    Assignee: BIOGAIA AB
    Inventors: Eamonn Connolly, Bo Mollstam
  • Publication number: 20150150917
    Abstract: The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been selected according to the presented method. The selection method is based on the strain's capability of reestablishing an altered microbial community to normal and/or harboring at least one of four specific SNPs.
    Type: Application
    Filed: June 4, 2013
    Publication date: June 4, 2015
    Applicants: Michigan State University, BIOGAIA AB
    Inventors: Eamonn Connolly, Robert Allen Britton, II, Laura Rae McCabe
  • Patent number: 8658157
    Abstract: New strains of Lactobacillus that have been selected for their capability of improved reduction the number of Streptococcus mutans in the mouth of mammals through inhibiting activity in combination with better binding to the oral mucins and dental plaque, thereby preventing, reducing or treating dental caries, and products derived from said strains, including agents for treatment or prophylaxis of caries for administration to humans.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: February 25, 2014
    Assignee: Biogaia AB
    Inventors: Bo Mollstam, Eamonn Connolly
  • Patent number: 8603460
    Abstract: The invention provides certain plasmid cured strains of lactic acid bacteria modified for their capability of better acid-tolerance, a method of modifying such strains, and products containing such strains.
    Type: Grant
    Filed: June 5, 2006
    Date of Patent: December 10, 2013
    Assignee: Brogaia AB
    Inventor: Eamonn Connolly
  • Patent number: 8496924
    Abstract: This invention relates to the selection and use of nonpathogenic, lysine-uptake stimulating lactic acid bacteria strains, and products and methods using such strains for example for improvement of fur-coat and claws quality in pet-animals.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: July 30, 2013
    Assignee: Biogala AB
    Inventors: Eamonn Connolly, Bo Mollstam
  • Publication number: 20130149291
    Abstract: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an. active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production, of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.
    Type: Application
    Filed: February 13, 2013
    Publication date: June 13, 2013
    Inventors: James Versalovic, Carissa Michelle Thomas, Eamonn Connolly
  • Publication number: 20130121932
    Abstract: New strains of Lactobacillus that have been selected for their capability of improved reduction the number of Streptococcus mutans in the mouth of mammals through inhibiting activity in combination with better binding to the oral mucins and dental plaque, thereby preventing, reducing or treating dental caries, and products derived from said strains, including agents for treatment or prophylaxis of caries for administration to humans.
    Type: Application
    Filed: November 5, 2012
    Publication date: May 16, 2013
    Inventors: Bo Mollstam, Eamonn Connolly
  • Publication number: 20130022586
    Abstract: A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions.
    Type: Application
    Filed: July 19, 2012
    Publication date: January 24, 2013
    Inventors: James Versalovic, Carissa Michelle Thomas, Eamonn Connolly
  • Patent number: 8343483
    Abstract: New strains of Lactobacillus that have been selected for their capability of improved reduction the number of Streptococcus mutans in the mouth of mammals through inhibiting activity in combination with better binding to the oral mucins and dental plaque, thereby preventing, reducing or treating dental caries, and products derived from said strains, including agents for treatment or prophylaxis of caries for administration to humans.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: January 1, 2013
    Assignee: Biogaia AB
    Inventors: Bo Mollstam, Eamonn Connolly
  • Publication number: 20120121564
    Abstract: The invention herein provides certain strains of lactic acid bacteria selected for their capability of promoting production of IL-10 and consequently proliferation of CD4+CD25+ TR cells, for prophylaxis and/or treatment of infant colic, a method of selecting such strains, and products containing such strains.
    Type: Application
    Filed: January 23, 2012
    Publication date: May 17, 2012
    Applicant: BIOGAIA AB
    Inventors: Eamonn Connolly, Bo Mollstam
  • Patent number: 7960137
    Abstract: Strains of Lactobacillus which have been selected for their capability of reducing gastrointestinal inflammation, such as that due to Helicobacter pylori, and products derived from these strains, including agents for treatment or prophylaxis of inflammation associated with Helicobacter pylori for administration to humans and include conditioned media in which the selected strains have grown and protein-containing extracts of the conditioned media.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: June 14, 2011
    Assignee: Biogala AB
    Inventors: Eamonn Connolly, Bo Mollstam
  • Publication number: 20110086126
    Abstract: This invention relates to the selection and use of nonpathogenic, lysine-uptake stimulating lactic acid bacteria strains, and products and methods using such strains for example for improvement of fur-coat and claws quality in pet-animals.
    Type: Application
    Filed: November 16, 2010
    Publication date: April 14, 2011
    Inventors: Eamonn Connolly, Bo Mollstam
  • Publication number: 20110081328
    Abstract: Strains of lactic acid bacteria selected for their capability of increasing the BSH-activity and consequently lowering serum LDL-cholesterol, and simultaneously decreasing the pro-inflammatory cytokine TNF-? levels, for prophylaxis and/or treatment of atherosclerosis and other cardiovascular diseases, a method of selecting such strains, and products containing such strains.
    Type: Application
    Filed: November 18, 2010
    Publication date: April 7, 2011
    Inventors: Peter Rothschild, Eamonn Connolly, Bo Mollstam
  • Patent number: 7910127
    Abstract: This invention relates to the selection and use of nonpathogenic, lysine-uptake stimulating lactic acid bacteria strains, and products and methods using such strains for example for improvement of fur-coat and claws quality in pet-animals.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: March 22, 2011
    Assignee: Biogaia AB
    Inventors: Eamonn Connolly, Bo Mollstam
  • Publication number: 20100129337
    Abstract: Strains of Lactobacillus which have been selected for their capability of reducing gastrointestinal inflammation, such as that due to Helicobacter pylori, and products derived from these strains, including agents for treatment or prophylaxis of inflammation associated with Helicobacter pylori for administration to humans and include conditioned media in which the selected strains have grown and protein-containing extracts of the conditioned media.
    Type: Application
    Filed: January 25, 2010
    Publication date: May 27, 2010
    Inventors: Eamonn Connolly, Bo Mollstam
  • Patent number: 7678553
    Abstract: Strains of Lactobacillus which have been selected for their capability of reducing gastrointestinal inflammation, such as that due to Helicobacter pylori, and products derived from these strains, including agents for treatment or prophylaxis of inflammation associated with Helicobacter pylori for administration to humans and include conditioned media in which the selected strains have grown and protein-containing extracts of the conditioned media.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: March 16, 2010
    Assignee: Biogaia AB
    Inventors: Eamonn Connolly, Bo Mollstam
  • Publication number: 20090238774
    Abstract: The invention herein relates to the use of nonpathogenic, anti-inflammatory and anti-bleeding lactic acid bacteria strains, and products and methods using such strains for treatment and prophylaxis of bleeding gum and gingivitis caused by oral inflammation.
    Type: Application
    Filed: April 2, 2009
    Publication date: September 24, 2009
    Inventors: EAMONN CONNOLLY, BO MOLLSTAM