Patents by Inventor Earl Danielson
Earl Danielson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070077657Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing.Type: ApplicationFiled: March 24, 2006Publication date: April 5, 2007Applicant: Symyx Technologies, Inc.Inventors: Eric Carlson, Peijun Cong, William Chandler, Henry Chau, Earl Danielson, Peter Desrosiers, Robert Doolen, Luping Wu, C. Ramberg, Thomas Crevier, Ralph Nielsen, Colin Masui, John Varni
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Publication number: 20060118493Abstract: Mesoscopically ordered, hydrothermally stable metal oxide-block copolymer composite or mesoporous materials are described herein that are formed by using amphiphilic block copolymers which act as structure directing agents for the metal oxide in a self-assembling system.Type: ApplicationFiled: December 15, 2003Publication date: June 8, 2006Inventors: Bradley Chmelka, Earl Danielson, Galen Stucky
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Patent number: 6850002Abstract: A device for the generation of specific colored light including white light by luminescent down conversion and additive color mixing based on a light-emitting diode (LED) comprising a semiconductor light-emitting layer emitting near UV light about 370-420 nm or blue light about 420-480 nm and phosphors which absorb completely or partly the light emitted by the light-emitting component and emit light of wavelengths longer than that of the absorbed primary light, wherein the light emitting layer of the light emitting component is preferably a Ga(In)N-based semiconductor; and at least one of the phosphors contains a metal sulfide fluorescent material activated with europium containing at least one element selected from the group consisting of Ba, Sr, Ca, Mg and Zn; and/or at least another phosphor which contains a complex thiometalate fluorescent material activated with either europium, cerium or both europium and cerium containing 1) at least one element selected from the group consisting of Ba, Sr, Ca, Mg andType: GrantFiled: July 27, 2001Date of Patent: February 1, 2005Assignees: Osram Opto Semiconductors GmbH, Symyx Technologies Inc.Inventors: Earl Danielson, Andries Ellens, Frank Jermann, Wolfgang Rossner, Martin Devenney, Daniel Giaquinta, Manfred Kobusch
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Publication number: 20050009081Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetizaton, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions.Type: ApplicationFiled: August 6, 2004Publication date: January 13, 2005Inventors: Eric McFarland, Earl Danielson, William Archibald
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Patent number: 6833921Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions.Type: GrantFiled: May 21, 2002Date of Patent: December 21, 2004Assignee: Symyx Technologies, Inc.Inventors: Eric W. McFarland, Earl Danielson, William Archibald
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Patent number: 6818110Abstract: An electrochemical deposition and testing system consisting of individually addressable electrode arrays, a fully automated deposition head, and a parallel screening apparatus is described. The system is capable of synthesizing and screening millions of new compositions at an unprecedented rate.Type: GrantFiled: October 23, 2000Date of Patent: November 16, 2004Assignee: Symyx Technologies, Inc.Inventors: Christopher J. Warren, Robert C. Haushalter, Leonid Matsiev, Martin Devenney, Eric McFarland, Earl Danielson
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Publication number: 20040144726Abstract: Mesoscopically ordered, hydrothermally stable metal oxide-block copolymer composite or mesoporous materials are described herein that are formed by using amphiphilic block copolymers which act as structure directing agents for the metal oxide in a self-assembling system.Type: ApplicationFiled: April 5, 2004Publication date: July 29, 2004Inventors: Bradley F. Chmelka, Earl Danielson, Galen D. Stucky
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Publication number: 20040124758Abstract: A device for the generation of specific colored light including white light by luminescent down conversion and additive color mixing based on a light-emitting diode (LED) comprising a semiconductor light-emitting layer emitting near UV light about 370-420 nm or blue light.Type: ApplicationFiled: January 23, 2003Publication date: July 1, 2004Applicants: Osram Opto Semiconductors Gmbh, Symyx Technologies, Inc.Inventors: Earl Danielson, Andries Ellens, Frank Jermann, Wolfgang Rossner, Martin Devenney, Daniel Giaquinta, Manfred Kobusch
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Publication number: 20040071888Abstract: The present invention is generally relates to the field of research for the discovery of films with desirable properties, and to a process for making such films. More particularly, the present invention is directed to a system or an apparatus and a method for the rapid formation of a library of liquid samples and a library of thin films therefrom, as well as to the rapid screening of these films to identify those having desirable properties, all of which may be achieved using combinatorial techniques.Type: ApplicationFiled: May 30, 2003Publication date: April 15, 2004Applicants: Symyx Technologies, Inc., Air Products and Chemicals, Inc.Inventors: Konstantinos Chondroudis, Keith Cendak, Martin Devenney, C. Eric Ramberg, Xuejun (Jason) Wang, Raymond E. Carhart, Scott Jeffrey Weigel, John Francis Kirner, Thomas Alan Deis, Earl Danielson, James Edward MacDougall, Lisa Deis, Sum Nguyen
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Publication number: 20030124028Abstract: The invention provides methods, apparatus, and systems for performing high-throughput preparation and screening of salts and polymorphs of drug candidates. The invention is directed towards enhancing the pre-formulation discovery process used for drug development. In particular, processes that determine suitable salts and processes that discover substantially every polymorph that can form from a particular drug candidate are provided. The processes are performed using several apparatuses that are specifically configured to carry-out various steps in a high-throughput characterization process. One such apparatus is configured for synthesizing a plurality of library members based on, for example, a library model generated by a computer system. Another apparatus may filter the synthesized solution to provide a substantially pure mixture that can be subjected to salt or polymorph testing.Type: ApplicationFiled: May 24, 2002Publication date: July 3, 2003Inventors: Eric D. Carlson, Peijun Cong, William H. Chandler, Henry K. Chau, Earl Danielson, Peter J. Desrosiers, Robert D. Doolen, Luping Wu, C. Eric Ramberg, Thomas Crevier, Ralph B. Nielsen, Colin S. Masui, John F. Varni
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Publication number: 20030104481Abstract: Methods and apparatus are provided for the preparation of a substrate having an array of diverse materials, the materials being deposited at spatially addressable, predefined regions. In particular, potential masking systems are provided which generate spatially and temporally varying electric, magnetic and chemical potentials across a substrate. These varying potentials are used to deposit components of source materials onto a substrate in a combinatorial fashion, thus creating arrays of materials that differ slightly in chemical composition, concentration, stoichiometry, and/or thickness. The diverse materials may be organized in discrete arrays, or they may vary continuously over the surface of the substrate. The shape of the potential allows the determination of the composition of the resulting materials at all locations on the substrate.Type: ApplicationFiled: November 4, 2002Publication date: June 5, 2003Applicant: SYMYX TECHNOLOGIESInventors: Eric McFarland, Earl Danielson, Martin Devenney, Christopher J. Warren
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Publication number: 20030055587Abstract: A library of materials is screened for characteristics. Accordingly, a library of materials is provided and an electromagnetic wavefront is directed at each member of the library. The electromagnetic wavefront is monitored for a response after the wavefront encounters the at least for sample materials. Thereafter, the response of the electromagnetic wavefront is correlated to a characteristic of the at least four sample materials.Type: ApplicationFiled: September 17, 2001Publication date: March 20, 2003Applicant: Symyx Technologies, Inc.Inventors: Youqi Wang, Qun Fan, C. Eric Ramberg, Earl Danielson, Damian A. Hajduk
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Publication number: 20030032205Abstract: Methods and apparatus are provided for the preparation of a substrate having an array of diverse materials, the materials being deposited at spatially addressable, predefined regions. In particular, potential masking systems are provided which generate spatially and temporally varying electric, magnetic and chemical potentials across a substrate. These varying potentials are used to deposit components of source materials onto a substrate in a combinatorial fashion, thus creating arrays of materials that differ slightly in chemical composition, concentration, stoichiometry, and/or thickness. The diverse materials may be organized in discrete arrays, or they may vary continuously over the surface of the substrate. The shape of the potential allows the determination of the composition of the resulting materials at all locations on the substrate.Type: ApplicationFiled: August 27, 2002Publication date: February 13, 2003Applicant: SYMYX TECHNOLOGIESInventors: Eric McFarland, Earl Danielson, Martin Devenney, Christopher J. Warren
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Publication number: 20030007152Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions.Type: ApplicationFiled: May 21, 2002Publication date: January 9, 2003Applicant: Symyx Technologies, Inc.Inventors: Eric W. McFarland, Earl Danielson, William Archibald
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Patent number: 6468806Abstract: Methods and apparatus are provided for the preparation of a substrate having an array of diverse materials, the materials being deposited at spatially addressable, predefined regions. In particular, potential masking systems are provided which generate spatially and temporally varying electric, magnetic and chemical potentials across a substrate. These varying potentials are used to deposit components of source materials onto a substrate in a combinatorial fashion, thus creating arrays of materials that differ slightly in chemical composition, concentration, stoichiometry, and/or thickness. The diverse materials may be organized in discrete arrays, or they may vary continuously over the surface of the substrate. The shape of the potential allows the determination of the composition of the resulting materials at all locations on the substrate.Type: GrantFiled: September 30, 1997Date of Patent: October 22, 2002Assignee: Symyx Technologies, Inc.Inventors: Eric McFarland, Earl Danielson, Martin Devenney, Christopher J. Warren
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Patent number: 6441901Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions.Type: GrantFiled: June 5, 2001Date of Patent: August 27, 2002Assignee: Symyx Technologies, Inc.Inventors: Eric W. McFarland, Earl Danielson, William Archibald
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Patent number: 6373570Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions.Type: GrantFiled: December 29, 1999Date of Patent: April 16, 2002Assignee: Symyx Technologies, Inc.Inventors: Eric W. McFarland, Earl Danielson, William Archibald
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Patent number: 6315923Abstract: Storage phosphors comprising an activated garnet host comprising oxygen and combined elements satisfying the relationship Ln3+&dgr;M5−&dgr;:cQ wherein Ln is an element selected from the group consisting of Gd, La, Lu, Y and combinations thereof; M is an element selected from the group consisting of Al, Ga, Sc, Fe and combinations thereof; Q is selected from the group consisting of terbium, samarium, thallium, indium, europium, ytterbium and combinations thereof; &dgr; is greater lo than or equal to minus 0.5, but less than or equal to 0.5 (i.e., −0.5≦&dgr;≦0.5); and c is an amount sufficient to produce a phosphor that exhibits a higher luminescence emission intensity than said phosphor absent Q when, after first being exposed to penetrating radiaton, the phosphor is stimulated by light of a wavelength ranging from 600 to 1200 nm or thermally.Type: GrantFiled: November 12, 1999Date of Patent: November 13, 2001Assignees: Symyx Technologies, Inc, AGFA-Gevaert, N.V.Inventors: Martin Devenney, Earl Danielson, Paul Leblans
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Publication number: 20010033375Abstract: Methods and apparatus for screening diverse arrays of materials are provided. In particular, techniques for rapidly characterizing compounds in arrays of materials in order to discover and/or optimize new materials with specific desired properties are provided. The substrate can be screened for materials having useful properties, and/or the resulting materials can be ranked, or otherwise compared, for relative performance with respect to useful properties or other characterizations. In particular, systems and methods are provided for screening a library of magnetic materials for their bulk magnetization, saturation magnetization, and coercivity by imaging their individual optical Kerr rotation, screening a library of dielectric materials for their dielectric coefficients by imaging their individual electro-optical rotation and screening a library of luminescent materials by imaging their individual luminescent properties under a variety of excitation conditions.Type: ApplicationFiled: June 5, 2001Publication date: October 25, 2001Applicant: Symyx Technologies, Inc.Inventors: Eric W. McFarland, Earl Danielson, William Archibald
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Patent number: 6203726Abstract: This invention relates generally to new luminescent materials. Specifically, this invention relates to the discovery of phosphor materials in the forms of A2BX4, ABX4-y:M and A3-zB5X12:Mz. More specifically, this invention relates to the discovery of phosphor materials having compositions of matter in the forms, Sr2CeO4, (Y0.82Al0.07La0.06)VO4:Eu0.05 and (Y0.5Gd0.5)2.97(Al0.5Gd0.5)5O12:Ce0.03.Type: GrantFiled: October 7, 1999Date of Patent: March 20, 2001Assignee: Symyx Technologies, Inc.Inventors: Earl Danielson, Martin Devenney, Daniel M. Giaquinta