Patents by Inventor Earl May

Earl May has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay for B-Raf activity based on intrinsic MEK ATPase activity
    Publication number: 20060211073
    Abstract: The present invention provides a convenient assay to identify compounds with B-Raf inhibitory activity, referred to as the BRAMA (B-Raf Accelerated MEK ATPase) assay. The BRAMA assay is based on the discovery of ATPase activity of MEK, and utilizes changes in NADH concentration over time as an indicator of the production of ADP by activated MEK ATPase, where the MEK ATPase activity is activated by B-Raf. NADH concentration may conveniently be measured by Optical Density.
    Type: Application
    Filed: March 21, 2005
    Publication date: September 21, 2006
    Inventors: Earl May, Cynthia Rominger, Michael Schaber
  • dnaE
    Publication number: 20020119511
    Abstract: The invention provides dnaE polypeptides and polynucleotides encoding dnaE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing dnaE polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: August 9, 2001
    Publication date: August 29, 2002
    Inventors: Earl May, Stephanie Van Horn, Patrick V. Warren, Richard L. Warren
  • PcrA helicase
    Patent number: 6391600
    Abstract: The invention provides PcrA Helicase polypeptides and polynucleotides encodi PcrA Helicase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing PcrA Helicase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: May 21, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Damien McDevitt, Earl May, Annemarie St John, Stephanie Van Horn
  • dnaE
    Patent number: 6280990
    Abstract: The invention provides dnaE polypeptides and polynucleotides encoding dnaE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing dnaE polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: August 28, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Earl May, Stephanie Van Horn, Patrick V Warren, Richard L Warren
  • PcrA Helicase of Staphylococcus aureus
    Patent number: 6197546
    Abstract: The invention provides PcrA Helicase polypeptides and polynucleotides encoding PcrA Helicase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing PcrA Helicase polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: March 6, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Damien McDevitt, Earl May, Annemarie St John, Stephanie Van Horn