Patents by Inventor Earl Pursell

Earl Pursell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-cell density fed-batch fermentation process for producing recombinant protein
    Patent number: 8632995
    Abstract: Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and optionally continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions and compositions for use in the methods of the present invention, are provided.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: January 21, 2014
    Assignee: Wyeth LLC
    Inventors: Wei-Qiang Willie Sun, Earl Pursell
  • Process for increasing RSV surface glycoprotein yields using a mutant strain of RSV
    Patent number: 7687240
    Abstract: A process for producing isolated and purified respiratory syncytial virus (RSV) fusion (F) and attachment (G) glycoproteins in eukaryotic cell cultures infected with RSV cold-passaged, temperature-sensitive mutant subgroup A2 strain cpts-248/404 results in at least a 5-fold increase in F and G protein yields when compared with the parent A2 strain. Immunogenic compositions comprising the F and/or G protein(s) produced by this process can be formulated for in vivo administration to a host to confer protection against disease caused by RSV.
    Type: Grant
    Filed: March 17, 2004
    Date of Patent: March 30, 2010
    Assignee: Wyeth Holdings Corporation
    Inventors: Firelli Alonso-Caplen, Mark Cutler, Mirelli Fino, Earl Pursell, Robert Repetto
  • High-Cell Density Fed-Batch Fermentation Process for Producing Recombinant Protein
    Publication number: 20080026425
    Abstract: Methods for producing proteins, for example, recombinant meningococcal 2086 proteins, using fed-batch fermentation with continuous input of an inducer after achieving a threshold parameter, and optionally continuous input of a carbon source, for example, a constant rate input, to improve protein yields, as well as high density protein compositions and compositions for use in the methods of the present invention, are provided.
    Type: Application
    Filed: July 27, 2007
    Publication date: January 31, 2008
    Inventors: Wei-Qiang Willie Sun, Earl Pursell
  • Process for increasing rsv surface glycoprotein yields using a mutant strain of rsv
    Publication number: 20060171955
    Abstract: A process for producing isolated and purified respiratory syncytial virus (RSV) fusion (F) and attachment (G) glycoproteins in eukaryotic cell cultures infected with RSV cold-passaged, temperature-sensitive mutant subgroup A2 strain cpts-248/404 results in at least a 5-fold increase in F and G protein yields when compared with the parent A2 strain. Immunogenic compositions comprising the F and/or G protein(s) produced by this process can be formulated for in vivo administration to a host to confer protection against disease caused by RSV.
    Type: Application
    Filed: March 17, 2004
    Publication date: August 3, 2006
    Inventors: Firelli Alonso-Caplen, Mark Cutler, Mirelli Fino, Earl Pursell, Robert Repetto