Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

Abstract: At a managed control plane service, end-user application programming interfaces (APIs) of an application to be implemented at a provider network are determined. A set of common operational requirements of the application, to be fulfilled without obtaining program code for the requirements, are identified. In response to an invocation of an end-user API of the application, computations are performed at a resource selected by the managed control plane service, and one or more tasks to satisfy a common operational requirement are initiated by the managed control plane service.

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

Abstract: A sprocket damping assembly for a sprocket wheel of a track-type work machine may include an annular damping ring having an annular retention device. The damping ring may include a ring body section having a ring body section radial thickness, and a retention groove section integrally formed at an outboard side of the ring body section. The retention groove section may have a retention groove section axial width and a retention groove section radial thickness. The retention device may have a retention device axial width that is less than or equal to the retention groove section axial width. The retention device is disposed on the retention groove section when the damping ring is disposed on a sprocket drum outer surface of the sprocket wheel to retain the sprocket damping assembly. The retention groove section radial thickness may be less than the ring body section radial thickness.

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

Abstract: At a managed control plane service, end-user application programming interfaces (APIs) of an application to be implemented at a provider network are determined. A set of common operational requirements of the application, to be fulfilled without obtaining program code for the requirements, are identified. In response to an invocation of an end-user API of the application, computations are performed at a resource selected by the managed control plane service, and one or more tasks to satisfy a common operational requirement are initiated by the managed control plane service.

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

Abstract: A sprocket damping assembly for a sprocket wheel of a track-type work machine may include an annular damping ring having an annular retention device. The damping ring may include a ring body section having a ring body section radial thickness, and a retention groove section integrally formed at an outboard side of the ring body section. The retention groove section may have a retention groove section axial width and a retention groove section radial thickness. The retention device may have a retention device axial width that is less than or equal to the retention groove section axial width. The retention device is disposed on the retention groove section when the damping ring is disposed on a sprocket drum outer surface of the sprocket wheel to retain the sprocket damping assembly. The retention groove section radial thickness may be less than the ring body section radial thickness.

Abstract: A battery housing can include a housing body defining a cavity sized and shaped to receive a cell for a battery, and a breaker coupled with the housing body. The battery housing can comprise a first electrical conductor at a first end portion of the housing body and electrically connected to the switch, the first electrical conductor configured to electrically connect to a first battery cell terminal of the cell. The battery housing can comprise a second electrical conductor at a second end portion of the housing body, the second electrical conductor configured to electrically connect to a second battery cell terminal of the cell to define a first electrical pathway between the first electrical conductor and the second electrical conductor. The battery housing can include a bypass conductor to define a second electrical pathway between the switch and the second electrical conductor.

Abstract: A request is received by a provider network from a requestor for data associated with a customer of the provider network. The data is not stored at the provider network, and the request includes a first encryption key. The provider network verifies that the requestor is authorized to request data from the customer of the multi provider network. The provider network sends information pertaining to the requested data to the customer. The provider network also sends the identity of the requestor and the first encryption key. The provider network sends, to the requestor, data that is encrypted, and a decryption key for decrypting the encrypted data.

Abstract: A suspension assembly for a machine is provided. The suspension assembly includes a first suspension structure and a second suspension structure. The first suspension structure includes a first suspension pad and a first support plate coupled to the first suspension pad. The first support plate has a first interlock component formed therein. The second suspension structure includes a second suspension pad and a second support plate coupled to the second suspension pad. The second support plate has a second interlock component formed therein. The second interlock component is complimentary to the first interlock component and configured to engage with the first interlock component.

Abstract: An electrical breaker responsive to a fault condition is disclosed. A thermally-activated switch can be disposed between a first terminal and second and third terminals of the breaker. The switch can have a normal operating condition in which the first terminal is electrically connected to the second terminal. The switch can have a fault condition in which the first terminal is electrically connected to both the second terminal and the third terminal, causing a majority of the current to flow between the first terminal and the third terminal and a minority of the current to flow between the first terminal and the second terminal. The breaker can include a positive temperature coefficient (PTC) resistor between the first terminal and one of the second and third terminals. The thermally-activated switch can be integrated into a variety of structures, for example, a battery pack which can house one or more cells.

Abstract: A battery housing can include a housing body defining a cavity sized and shaped to receive a cell for a battery, and a breaker coupled with the housing body. The battery housing can comprise a first electrical conductor at a first end portion of the housing body and electrically connected to the switch, the first electrical conductor configured to electrically connect to a first battery cell terminal of the cell. The battery housing can comprise a second electrical conductor at a second end portion of the housing body, the second electrical conductor configured to electrically connect to a second battery cell terminal of the cell to define a first electrical pathway between the first electrical conductor and the second electrical conductor. The battery housing can include a bypass conductor to define a second electrical pathway between the switch and the second electrical conductor.

Abstract: A suspension assembly for a machine is provided. The suspension assembly includes a first suspension structure and a second suspension structure. The first suspension structure includes a first suspension pad and a first support plate coupled to the first suspension pad. The first support plate has a first interlock component formed therein. The second suspension structure includes a second suspension pad and a second support plate coupled to the second suspension pad. The second support plate has a second interlock component formed therein. The second interlock component is complimentary to the first interlock component and configured to engage with the first interlock component.

Abstract: A suspension assembly for a machine is provided. The suspension assembly includes a first suspension structure and a second suspension structure. The first suspension structure includes a first suspension pad and a first support plate coupled to the first suspension pad. The first support plate has a first interlock component formed therein. The second suspension structure includes a second suspension pad and a second support plate coupled to the second suspension pad. The second support plate has a second interlock component formed therein. The second interlock component is complimentary to the first interlock component and configured to engage with the first interlock component.

Abstract: The invention provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is MTAP-deficient and/or MTA-accumulating and thus amenable to therapeutic treatment with a PRMT5 inhibitor. Kits, methods of screening for candidate PRMT5 inhibitors, and associated methods of treatment are also provided.

Abstract: A request is received by a provider network from a requestor for data associated with a customer of the provider network. The data is not stored at the provider network, and the request includes a first encryption key. The provider network verifies that the requestor is authorized to request data from the customer of the multi provider network. The provider network sends information pertaining to the requested data to the customer. The provider network also sends the identity of the requestor and the first encryption key. The provider network sends, to the requestor, data that is encrypted, and a decryption key for decrypting the encrypted data.

Abstract: A battery housing can include a housing body defining a cavity sized and shaped to receive a cell for a battery, and a breaker coupled with the housing body. The battery housing can comprise a first electrical conductor at a first end portion of the housing body and electrically connected to the switch, the first electrical conductor configured to electrically connect to a first battery cell terminal of the cell. The battery housing can comprise a second electrical conductor at a second end portion of the housing body, the second electrical conductor configured to electrically connect to a second battery cell terminal of the cell to define a first electrical pathway between the first electrical conductor and the second electrical conductor. The battery housing can include a bypass conductor to define a second electrical pathway between the switch and the second electrical conductor.

Abstract: An electrical breaker responsive to a fault condition is disclosed. A thermally-activated switch can be disposed between a first terminal and second and third terminals of the breaker. The switch can have a normal operating condition in which the first terminal is electrically connected to the second terminal. The switch can have a fault condition in which the first terminal is electrically connected to both the second terminal and the third terminal, causing a majority of the current to flow between the first terminal and the third terminal and a minority of the current to flow between the first terminal and the second terminal. The breaker can include a positive temperature coefficient (PTC) resistor between the first terminal and one of the second and third terminals. The thermally-activated switch can be integrated into a variety of structures, for example, a battery pack which can house one or more cells.

Abstract: A telemetry system for data transmission between an implantable medical device and an external system includes a plurality of channels each representing a frequency band within a predetermined frequency range. The data transmission is performed using at least one active channel at any instant. Channel hopping is performed upon detecting an interruption of communication, such that a scan is performed through an array of channels selected from the plurality of channels. If a data frame is not successfully transmitted, it is repeatedly re-transmitted using the current and/or the next active channels until its transmission becomes successful.