Patents by Inventor Ebbe R.o slashed.nne

Ebbe R.o slashed.nne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6113897
    Abstract: A monoclonal or polyclonal antibody directed against urokinase plasminogen activator receptor (u-PAR), or a subsequence, analogue or glycosylation variant thereof. Antibodies are disclosed which react with free u-PAR or with complexes between u-PA and u-PAR and which are capable of 1) catching u-PAR in ELISA, or 2) detecting u-PAR, e.g. in blotting, or 3) in radioimmunoprecipitation assay precipitate purified u-PAR in intact or fragment form, or 4) is useful for immunohistochemical detection of u-PAR, e.g. in immunostaining of cancer cells, such as in tissue sections at the invasive front, or 5) inhibits the binding of pro-u-PA and active u-PA and thereby inhibits cell surface plasminogen activation. Methods are disclosed 1) for detecting or quantifying u-PAR, 2) for targeting a diagnostic to a cell containing a u-PAR on the surface, 3) for preventing or counteracting proteolytic activity in a mammal.
    Type: Grant
    Filed: December 28, 1995
    Date of Patent: September 5, 2000
    Assignee: Cancerforskiningsfonden af 1989
    Inventors: Keld Dan.o slashed., Ebbe R.o slashed.nne, Niels Behrendt, Vincent Ellis, Gunilla H.o slashed.yer-Hansen, Charles Pyke, Nils Bruenner
  • Patent number: 5891664
    Abstract: Activation of plasminogen to plasma is inhibited by preventing the binding of a receptor binding form of urokinase-type plasminogen activator to a urokinase-type plasminogen activator receptor in a mammal, thereby preventing the urokinase-type plasminogen activator from converting plasminogen into plasmin. DNA fragments which encode for soluble, active fragments of the urokinase-type plasminogen activator are provided.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: April 6, 1999
    Assignee: Cancerforskningsfondet af 1989
    Inventors: Keld Dan.o slashed., Francesco Blasi, Ann Louring Roldan, Maria Vittoria Cubellis, Maria Teresa Masucci, Ettore Appella, Wolf-Dieter Schleuning, Niels Behrendt, Ebbe R.o slashed.nne, Peter Kristensen, Jari Pollanen, Eeva-Marjatta Salonen, Ross W. Stephens, Hannele Tapiovaara, Antti Vaheri, Lisbeth Birk M.o slashed.ller, Vincent Ellis, Leif R.o slashed.ge Lund, Michael Ploug, Charles Pyke, Laszlo Patthy