Patents by Inventor Eberhard Glaser
Eberhard Glaser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120171117Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.Type: ApplicationFiled: March 8, 2012Publication date: July 5, 2012Applicant: HAMMERSMITH IMANET LIMITEDInventors: ERIK ARSTAD, MATTHIAS EBERHARD GLASER
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Patent number: 8211403Abstract: The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I): with a compound of formula (II) or, a compound of formula (III): with a compound of formula (IV): in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.Type: GrantFiled: June 20, 2007Date of Patent: July 3, 2012Assignee: Hammersmith Imanet LimitedInventors: Matthias Eberhard Glaser, Erik Arstad
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Patent number: 8197793Abstract: The invention relates to conjugates of formula (V) or (VI): wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.Type: GrantFiled: March 12, 2004Date of Patent: June 12, 2012Assignee: GE Healthcare ASInventors: Alan Cuthbertson, Magne Solbakken, Joseph Maduabuchi Arukwe, Hege Karlsen, Matthias Eberhard Glaser
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Patent number: 8148575Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.Type: GrantFiled: April 20, 2007Date of Patent: April 3, 2012Assignee: Hammersmith Imanet LimitedInventors: Erik Arstad, Matthias Eberhard Glaser
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Patent number: 8071718Abstract: Provided herein are methods for introducing fluorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.Type: GrantFiled: December 20, 2007Date of Patent: December 6, 2011Assignee: General Electric CompanyInventors: Omayra Liz Padilla De Jesus, Ernest William Kovacs, Matthias Eberhard Glaser, Erik Arstad, Faisal Ahmed Syud
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Publication number: 20110236311Abstract: The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): or, a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.Type: ApplicationFiled: June 13, 2011Publication date: September 29, 2011Applicant: HAMMERSMITH IMANET LIMITEDInventors: ERIK ARSTAD, MATTHIAS EBERHARD GLASER
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Publication number: 20110195024Abstract: Isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising the derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders associated with dysregulation of apoptosis, methods for synthesizing the derivatives, methods for the molecular imaging of caspase activity and apoptosis, and methods of assessing the therapeutic effect of a test substance on caspase activity are disclosed.Type: ApplicationFiled: September 4, 2009Publication date: August 11, 2011Applicants: Imperial Innovations Limited, Hammersmith Imanet LimitedInventors: Eric Ofori Aboabye, Graham Smith, Quang-De Nguyen, Erik Arstad, Matthias Eberhard Glaser
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Publication number: 20110189089Abstract: The present invention relates to 18F radio-chemistry and in particular to a method for synthesising radiofluorinated amides and amines. The method of the invention has particular application in the radiosynthesis of a variety of 18F-labelled positron emission tomography (PET) tracers.Type: ApplicationFiled: October 20, 2009Publication date: August 4, 2011Inventors: Robert James Domett Nairne, Erik Arstad, Matthias Eberhard Glaser
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Patent number: 7972588Abstract: The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): R*-L2-N3 (II) or, a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.Type: GrantFiled: December 9, 2005Date of Patent: July 5, 2011Assignee: Hammersmith Imanet LimitedInventors: Erik Arstad, Matthias Eberhard Glaser
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Publication number: 20100068139Abstract: The invention relates to conjugates of formula (V) or (VI): wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—; their use as radiopharmaceuticals, processes for their preparation, and synthetic intermediates used in such processes.Type: ApplicationFiled: March 12, 2004Publication date: March 18, 2010Inventors: Alan Cuthbertson, Magne Solbakken, Joseph Maduabuchi Arukwe, Hege Karlsen, Matthias Eberhard Glaser
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Publication number: 20100040550Abstract: The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I): with a compound of formula (II) or, a compound of formula (III): with a compound of formula (IV): in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.Type: ApplicationFiled: June 20, 2007Publication date: February 18, 2010Inventors: Matthias Eberhard Glaser, Erik Arstad
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Publication number: 20090311177Abstract: The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): R*-L2-N3 (II) or, a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.Type: ApplicationFiled: December 9, 2005Publication date: December 17, 2009Inventors: Erik Arstad, Matthias Eberhard Glaser
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Publication number: 20090087379Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.Type: ApplicationFiled: April 20, 2007Publication date: April 2, 2009Inventors: Erik Arstad, Matthias Eberhard Glaser
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Publication number: 20080213174Abstract: The invention relates to in vivo imaging agents, specifically radiolabelled insulin derivatives of formula (III); wherein X is —CO—NH—, —NH—, —O—, —NHCONH—, or —NHCSNH—, and is preferably —CO—NH—, —NH— or —O—; Y is H, alkyl or aryl substituents; R* is a radiolabel moiety suitable for detection by SPECT or PET; and methods for preparing the same as well as their use in in vivo imaging methods.Type: ApplicationFiled: September 13, 2005Publication date: September 4, 2008Inventors: Matthias Eberhard Glaser, Frank Brady, Sajinder Kaur Luthra, Alan Cuthbertson, Hege Karlsen
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Publication number: 20080161537Abstract: Provided herein are methods for introducing fluorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.Type: ApplicationFiled: December 20, 2007Publication date: July 3, 2008Applicant: GENERAL ELECTRIC COMPANYInventors: Omayra Liz Padilla De Jesus, Ernest William Kovacs, Matthias Eberhard Glaser, Erik Arstad, Faisal Ahmed Syud
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Publication number: 20040236085Abstract: The present invention relates to novel solid-phase processes for the production of radiolabelled tracers, in particular for the production of 18F-labelled compounds which may be suitable for use as Positron Emission Tomography (PET) radiotracers. The invention also comprises radiopharmaceutical kits using these novel processes.Type: ApplicationFiled: July 15, 2004Publication date: November 25, 2004Inventors: Sajinder Kaur Luthra, Frank Brady, Harry John Wadsworth, Alexander Mark Gibson, Matthias Eberhard Glaser
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Patent number: 5505814Abstract: A welding device for welding a welding profile to an inner welding groove of a locking device, consisting of a first hollow profiled member inserted into a second hollow profile member, has a carriage with a housing whereby the carriage has a longitudinal axis and is movable in the longitudinal direction. A heating device is connected inside the housing. A pressing device for pressing the welding profile into the welding groove is connected inside the housing. The pressing device has a pressure-applying member. A clamping device for securing a lower flattened side of the welding profile is connected inside the housing. In the direction of supplying the welding profile the clamping device is arranged downstream of the heating device and the pressing device. The welding profile is guided from the heating device via the pressure-applying member to the clamping device.Type: GrantFiled: July 29, 1994Date of Patent: April 9, 1996Assignee: Ed. Zublin AktiengesellschaftInventors: Eberhard Glaser, Reiner Mock, Fridolin Wohlfarth, Heidrun Franz
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Patent number: 5458722Abstract: A method for connecting in a liquid-tight manner cooperating lock halves of a locking device of adjacent wall sections of a multi-sectioned wall introduced into a suspension includes providing a first lock half as an inner profiled member and a second lock half as an outer profiled member. The inner profiled member is inserted into the outer profiled member so that the profiled members substantially areally rest at one another and form a capillary gap. An inner groove is cut over the length of the lock halves such that the inner groove extends through the wall of the inner profiled member into the wall of the outer profiled member. The area of the wall of the inner profiled member where the inner groove is located is sealed against the suspension with a sealing material introduced into the gap. The inner and outer profiled members are fused with a fusing material introduced into the inner groove.Type: GrantFiled: July 29, 1994Date of Patent: October 17, 1995Assignee: Ed. Zubllin AktiengesellschaftInventors: Eberhard Glaser, Reiner Mock
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Patent number: 5316510Abstract: A method for recycling of coated glass, especially for reuse in a glass melt, comprises the steps of crushing the glass; transferring the crushed glass into a mixing unit; mixing the crushed glass for a predetermined time period; during the mixing step, adding liquid to the crushed glass and cleaning the crushed glass with the liquid; and removing the cleaned crushed glass from the mixing unit. The method is especially useful for recycling cathode-ray tubes.Type: GrantFiled: July 24, 1992Date of Patent: May 31, 1994Assignee: Ed. Zublin AktiengesellschaftInventors: Johann Muhlberger, Eberhard Glaser, Stefan Maier
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Patent number: 4990210Abstract: Apparatus is provided for introducing and joining diaphragms in slotted walls. The slotted inner connecting pipe of one diaphragm is introduced into the slotted outer connecting pipe of another diaphragm. Furthermore apparatus for fusing together the two connecting pipes is placed within the interior of the inner pipe and can move through the latter. The apparatus has a heating device for heating and fusing the two connecting pipes together.Type: GrantFiled: April 28, 1989Date of Patent: February 5, 1991Assignee: Ed. Zublin AktiengesellschaftInventors: Eberhard Glaser, Eberhard Beitinger, Manfred Nussbaumer