Patents by Inventor Eberhard Karl

Eberhard Karl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130156819
    Abstract: The present invention relates to peptides or fragments thereof, which peptides bind to mesenchymal stem cells. The present invention also relates to a method for identifying, isolating, specifically selecting and/or enriching mesenchymal stem cells, wherein the peptides, or fragments thereof, are employed for specifically binding to the mesenchymal stem cells. Also, the present invention relates to the use of the peptides of the invention, or fragments thereof, and of the mesenchymal stem cells isolated with the peptides of the invention, or fragments thereof, for treating, injuries and/or degenerated bone, cartilage or tissues.
    Type: Application
    Filed: December 5, 2012
    Publication date: June 20, 2013
    Applicants: Baden-Württemberg Stiftung gGmbH, Eberhard-Karls-Universit°t Tübingen Universit°tsklinikum
    Inventors: Eberhard-Karls-Universit°t Tübingen Universit°tskl, Baden-Württemberg Stiftung gGmbH
  • Publication number: 20130129736
    Abstract: The present invention relates to a method for the in vitro determination of the presence of or a predisposition of a patient to the development of cancer. In the method according to the invention, the presence of a marker is determined in a biological sample of the patient, said marker being selected from a) the amino acid sequence SEQ ID Nr. 2 from the sequence protocol that is provided, or b) a nucleic acid that encodes the amino acid sequence with the SEQ ID Nr. 2. The invention further relates to the amino acid and the encoding nucleic acid and to the use thereof in diagnostics and for molecular therapeutic approaches.
    Type: Application
    Filed: January 29, 2013
    Publication date: May 23, 2013
    Applicant: Eberhard-Karls-Universit.t Tubingen Universit. tsklinikum
    Inventor: Eberhard-Karls-Universit.t Tubingen Universit.tsklinikum
  • Publication number: 20130122078
    Abstract: The present invention relates to a method for the implantation of biological material into an organism.
    Type: Application
    Filed: January 4, 2013
    Publication date: May 16, 2013
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
  • Publication number: 20130108580
    Abstract: The present invention relates to a fusion protein comprising a) a first polypeptide selected from among SDF-1 (stromal cell derived factor-1) or peptidase/protease-resistant variants or fragments thereof which have the CXCR4-/CXCR7- binding function of SDF-1; and b) a second polypeptide which is selected from among GPVI (glycoprotein VI), or the extracellular domain of GPVI, or fragments or variants of the extracellular domain of GPVI which contain the collagen binding function of GPVI, wherein the first polypeptide and the second peptide are linked to one another directly or via a linker molecule. The invention furthermore relates to the use of the fusion protein for treating diseases.
    Type: Application
    Filed: September 28, 2012
    Publication date: May 2, 2013
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Eberhard-Karls-Universitaet Tuebingen Universita
  • Publication number: 20130078219
    Abstract: The present invention relates to a genetically modified Paramyxovirus, a pharmaceutical composition comprising this paramyxovirus, the use of a genetically modified Paramyxovirus for the therapeutic and/or prophylactic treatment of a tumor disease, and a method for the production of a pharmaceutical composition for the therapeutic or prophylactic treatment of a tumor disease.
    Type: Application
    Filed: October 22, 2012
    Publication date: March 28, 2013
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Eberhard-Karls-Universitaet Tuebingen Universitaet
  • Publication number: 20130078648
    Abstract: The present invention relates to a method for the visual examination of biological material ex vivo and an apparatus for the sterical orientation of biological material which can be used in said method.
    Type: Application
    Filed: November 16, 2012
    Publication date: March 28, 2013
    Applicant: Eberhard-Karls-Universitaet Tuebingen Universitaetsklinikum
    Inventor: Eberhard-Karls-Universitaet Tuebingen Universita
  • Patent number: 7175011
    Abstract: The invention relates to a free-wheel, in particular a pinch roller free-wheel or a pinch body free-wheel, comprising relatively-rotating elements arranged one within the other on a common axis, which form a gap, in which pinch elements, in particular pinch rollers or pinch bodies, are arranged such that a friction connection can be produced with the facing outer surfaces of the elements, by means of the pinch surfaces, whereby the free-wheel outer rim is covered by a ring of fibre-reinforced plastic and the external diameter of the ring of fibre-reinforced plastic is about 1.3 to 1.8 times the diameter of the external clamping surface.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: February 13, 2007
    Assignee: Paul Mueller GmbH & Co. KG Unternehmensbeteiligungen
    Inventors: Eberhard Kōhler, Holger Frei, Eberhard Karl, Manfred Elbacher
  • Publication number: 20050016812
    Abstract: The invention relates to a free-wheel, in particular a pinch roller free-wheel or a pinch body free-wheel, comprising relatively-rotating elements arranged one within the other on a common axis, which form a gap, in which pinch elements, in particular pinch rollers or pinch bodies, are arranged such that a friction connection can be produced with the facing outer surfaces of the elements, by means of the pinch surfaces, whereby the free-wheel outer rim is covered by a ring of fibre-reinforced plastic and the external diameter of the ring of fibre-reinforced plastic is about 1.3 to 1.8 times the diameter of the external clamping surface.
    Type: Application
    Filed: August 28, 2002
    Publication date: January 27, 2005
    Inventors: Eberhard Kohler, Holger Frei, Eberhard Karl, Manfred Elbacher
  • Patent number: 6096912
    Abstract: Abstract of the Disclosure: Catalyst systems for the polymerization of C.sub.2 -C.sub.10 -alk-1-enes contain, as active components,a) a metallocene complex of the general formula I ##STR1## where M is titanium, zirconium, hafnium, vanadium, niobium or tantalum, X is halogen or C.sub.1 -C.sub.8 -alkyl, Y is carbon, phosphorus, sulfur, silicon or germanium, Z is C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl or C.sub.6 -C.sub.10 -aryl, R.sup.1 and R.sup.2 are identical or different and are each C.sub.1 -C.sub.4 -alkyl, R.sup.3 to R.sup.6 are identical or different and are each hydrogen or C.sub.1 -C.sub.8 -alkyl, or two adjacent radicals R.sup.3 and R.sup.4 and R.sup.5 and R.sup.6 in each case together form a hydrocarbon ring system of 4 to 15 carbon atoms and n is 0, 1 or 2, andb) an open-chain or cyclic alumoxane compound of the general formula II or III ##STR2## where R.sup.7 is C.sub.1 -C.sub.4 -alkyl and n is from 5 to 30.
    Type: Grant
    Filed: May 3, 1996
    Date of Patent: August 1, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Eberhard Karl, Werner Roell, Hans Brintzinger, Bernhard Rieger, Udo Stehling
  • Patent number: 5514760
    Abstract: Catalyst systems for the polymerization of C.sub.2 -C.sub.10 -alk-1-enes contain, as active components,a) a metallocene complex of the general formula I ##STR1## where M is titanium, zirconium, hafnium, vanadium, niobium or tantalum, X is halogen or C.sub.1 -C.sub.8 -alkyl, Y is carbon, phosphorus, sulfur, silicon or germanium, Z is C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl or C.sub.6 -C.sub.10 -aryl, R.sup.1 and R.sup.2 are identical or different and are each C.sub.1 -C.sub.4 -alkyl, R.sup.3 to R.sup.6 are identical or different and are each hydrogen or C.sub.1 -C.sub.8 -alkyl, or two adjacent radicals R.sup.3 and R.sup.4 and R.sup.5 and R.sup.6 in each case together form a hydrocarbon ring system of 4 to 15 carbon atoms and n is 0, 1 or 2, andb) an open-chain or cyclic alumoxane compound of the general formula II or III ##STR2## where R.sup.7 is C.sub.1 -C.sub.4 -alkyl and n is from 5 to 30.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: May 7, 1996
    Assignee: BASF Aktiengesellschaft
    Inventors: Eberhard Karl, Werner Roell, Hans Brintzinger, Bernhard Rieger, Udo Stehling
  • Patent number: 5296434
    Abstract: Catalyst systems for the polymerization of C.sub.2 -C.sub.10 -alk-1-enes contain, as active components,a) a metallocene complex of the general formula I ##STR1## where M is titanium, zirconium, hafnium, vanadium, niobium or tantalum, X is halogen or C.sub.1 --C.sub.8 -alkyl, Y is carbon, phosphorus, sulfur, silicon or germanium, Z is C.sub.1 -C.sub.8 -alkyl, C.sub.3 -C.sub.10 -cycloalkyl or C.sub.6 -C.sub.10 -aryl, R.sup.1 and R.sup.2 are identical or different and are each C.sub.1 -C.sub.4 -alkyl, R.sup.3 to R.sup.6 are identical or different and are each hydrogen or C.sub.1 -C.sub.8 -alkyl, or two adjacent radicals R.sup.3 and R.sup.4 and R.sup.5 and R.sup.6 in each case together form a hydrocarbon ring system of 4 to 15 carbon atoms and n is 0, 1 or 2, andb) an open-chain or cyclic alumoxane compound of the general formula II or III ##STR2## where R.sup.7 is C.sub.1 -C.sub.4 -alkyl and n is from 5 to 30.
    Type: Grant
    Filed: June 18, 1992
    Date of Patent: March 22, 1994
    Assignee: BASF Aktiengesellschaft
    Inventors: Eberhard Karl, Werner Roell, Hans Brintzinger, Bernhard Rieger, Udo Stehling