Patents by Inventor Eberhard Russmann
Eberhard Russmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10689718Abstract: A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single none-degenerate forward primer partially overlapping the 5?UTR region of HEV and at least one reverse primer. Also disclosed are related methods comprising a probe, and kits for the detection of genotypes 1, 2, 3 and/or 4 of HEV.Type: GrantFiled: June 2, 2017Date of Patent: June 23, 2020Assignee: Roche Molecular Systems, Inc.Inventors: Hermann Leying, Thomas W. Myers, Nicolas Newton, Eberhard Russmann, Joseph San Filippo, Nancy Schoenbrunner, Heike Wilts, Xiaoning Wu, Karen K. Y. Young, Dirk Zimmermann
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Publication number: 20200190560Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.Type: ApplicationFiled: December 19, 2019Publication date: June 18, 2020Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
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Publication number: 20180208969Abstract: The present invention belongs to the field of in-vitro diagnostics. Within this field, it particularly concerns the amplification of at least a first target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer. It further provides an analytical system comprising an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer.Type: ApplicationFiled: January 12, 2018Publication date: July 26, 2018Inventors: Meike Eickhoff, Eberhard Russmann, Andreas Woelfelschneider, Dirk Zimmerman
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Publication number: 20180142282Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.Type: ApplicationFiled: June 30, 2017Publication date: May 24, 2018Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
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Patent number: 9920354Abstract: The present invention is in the field of in-vitro diagnostics. Within this field, it provides the amplification of at least a first target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer. It further provides an analytical system comprising an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer.Type: GrantFiled: December 16, 2011Date of Patent: March 20, 2018Assignee: Roche Molecular Systems, Inc.Inventors: Meike Eickhoff, Eberhard Russmann, Andreas Woelfelschneider, Dirk Zimmermann
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Publication number: 20170268074Abstract: A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single none-degenerate forward primer partially overlapping the 5?UTR region of HEV and at least one reverse primer. Also disclosed are related methods comprising a probe, and kits for the detection of genotypes 1, 2, 3 and/or 4 of HEV.Type: ApplicationFiled: June 2, 2017Publication date: September 21, 2017Inventors: Hermann Leying, Thomas W. Myers, Nicolas Newton, Eberhard Russmann, Joseph San Filippo, Nancy Schoenbrunner, Heike Wilts, Xiaoning Wu, Karen K. Y. Young, Dirk Zimmermann
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Patent number: 9725754Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.Type: GrantFiled: July 27, 2011Date of Patent: August 8, 2017Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
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Patent number: 9702017Abstract: A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single none-degenerate forward primer partially overlapping the 5?UTR region of HEV and at least one reverse primer. Also disclosed are related methods comprising a probe, and kits for the detection of genotypes 1, 2, 3 and/or 4 of HEV.Type: GrantFiled: April 17, 2013Date of Patent: July 11, 2017Inventors: Hermann Leying, Thomas W. Myers, Nicolas Newton, Eberhard Russmann, Joseph San Filippo, Nancy Schoenbrunner, Heike Wilts, Xiaoning Wu, Karen K. Y. Young, Dirk Zimmermann
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Publication number: 20130280697Abstract: A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single none-degenerate forward primer partially overlapping the 5?UTR region of HEV and at least one reverse primer. Also disclosed are related methods comprising a probe, and kits for the detection of genotypes 1, 2, 3 and/or 4 of HEV.Type: ApplicationFiled: April 17, 2013Publication date: October 24, 2013Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Hermann Leying, Thomas W. Myers, Nicolas Newton, Eberhard Russmann, Joseph San Filippo, Nancy Schoenbrunner, Heike Wilts, Xiaoning Wu, Karen K. Y. Young, Dirk Zimmermann
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Publication number: 20120190010Abstract: The present invention belongs to the field of in-vitro diagnostics. Within this field, it particularly concerns the amplification of at least a first target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer. It further provides an analytical system comprising an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer.Type: ApplicationFiled: December 16, 2011Publication date: July 26, 2012Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Meike Eickhoff, Eberhard Russmann, Andreas Woelfelschneider, Dirk Zimmermann
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Patent number: 8192958Abstract: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to a method for the detection of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof, optionally isolating the nucleic acid, optionally amplifying the nucleic acid, and detecting the nucleic acid. The invention is further related to a method for the purification of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof and isolating the nucleic acid thereby purifying the nucleic acid.Type: GrantFiled: December 8, 2011Date of Patent: June 5, 2012Assignee: Roche Molecular Systems, Inc.Inventors: Sigrid Adie, Hermann Leying, Nicole Nachbaur, Eberhard Russmann
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Publication number: 20120100599Abstract: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to a method for the detection of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof, optionally isolating the nucleic acid, optionally amplifying the nucleic acid, and detecting the nucleic acid. The invention is further related to a method for the purification of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof and isolating the nucleic acid thereby purifying the nucleic acid.Type: ApplicationFiled: December 8, 2011Publication date: April 26, 2012Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Sigrid Adie, Hermann Leying, Nicole Nachbaur, Eberhard Russmann
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Publication number: 20120045751Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.Type: ApplicationFiled: July 27, 2011Publication date: February 23, 2012Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
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Patent number: 8097717Abstract: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to a method for the detection of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof, optionally isolating the nucleic acid, optionally amplifying the nucleic acid, and detecting the nucleic acid. The invention is further related to a method for the purification of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof and isolating the nucleic acid thereby purifying the nucleic acid.Type: GrantFiled: August 24, 2011Date of Patent: January 17, 2012Assignee: Roche Molecular Systems, Inc.Inventors: Sigrid Adie, Hermann Leying, Nicole Nachbaur, Eberhard Russmann
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Publication number: 20110311982Abstract: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to a method for the detection of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof, optionally isolating the nucleic acid, optionally amplifying the nucleic acid, and detecting the nucleic acid. The invention is further related to a method for the purification of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof and isolating the nucleic acid thereby purifying the nucleic acid.Type: ApplicationFiled: August 24, 2011Publication date: December 22, 2011Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Sigrid Adie, Hermann Leying, Nicole Nachbaur, Eberhard Russmann
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Publication number: 20100173353Abstract: Subject matter of the invention is a lysis reagent formulation for binding components of a sample in the form of a tablet comprising a multitude of magnetic particles which are held together with the aid of excipients, a chaotropic salt and an excipient and the use of this lysis reagent formulation in analytical tests.Type: ApplicationFiled: July 8, 2009Publication date: July 8, 2010Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Stephanie Koennings, Leif Kuhler, Eberhard Russmann, Katja Schuster, Edward S. Smtih
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Publication number: 20080187905Abstract: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to a method for the detection of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof, optionally isolating the nucleic acid, optionally amplifying the nucleic acid, and detecting the nucleic acid. The invention is further related to a method for the purification of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof and isolating the nucleic acid thereby purifying the nucleic acid.Type: ApplicationFiled: December 11, 2007Publication date: August 7, 2008Applicant: ROCHE MOLECULAR SYSTEMS, INC.Inventors: Sigrid Adie, Hermann Leying, Nicole Nachbaur, Eberhard Russmann
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Patent number: 6538110Abstract: The invention concerns an antibody composition which inhibits the binding of interleukin 2 to its high affinity receptor and contains (1) monoclonal antibodies against the &agr; chain of the interleukin 2 receptor and (2) monoclonal antibodies against the &bgr; chain of the interleukin 2 receptor, as well as a pharmaceutical agent which contains the antibody composition according to the present invention.Type: GrantFiled: March 10, 1993Date of Patent: March 25, 2003Assignee: Roche DiagnosticsInventors: Ulrich Weidle, Eberhard Russmann, Klaus-Peter Hirth, Tiberiu Diamantstein, Brigitte Kaluza
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Patent number: 5700639Abstract: The invention concerns a method for the non-radioactive detection of metabolically labelled DNA, in one aspect detecting labelled DNA indicative of cell lysis or apoptosis.Type: GrantFiled: June 9, 1994Date of Patent: December 23, 1997Assignee: Boehringer Mannheim GmbHInventors: Bernhard Trauth, Matthias Hinzpeter, Clemens Doppler, Eberhard Russmann