Patents by Inventor Eberhard Russmann

Eberhard Russmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10689718
    Abstract: A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single none-degenerate forward primer partially overlapping the 5?UTR region of HEV and at least one reverse primer. Also disclosed are related methods comprising a probe, and kits for the detection of genotypes 1, 2, 3 and/or 4 of HEV.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: June 23, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Hermann Leying, Thomas W. Myers, Nicolas Newton, Eberhard Russmann, Joseph San Filippo, Nancy Schoenbrunner, Heike Wilts, Xiaoning Wu, Karen K. Y. Young, Dirk Zimmermann
  • Publication number: 20200190560
    Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.
    Type: Application
    Filed: December 19, 2019
    Publication date: June 18, 2020
    Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
  • Publication number: 20180208969
    Abstract: The present invention belongs to the field of in-vitro diagnostics. Within this field, it particularly concerns the amplification of at least a first target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer. It further provides an analytical system comprising an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer.
    Type: Application
    Filed: January 12, 2018
    Publication date: July 26, 2018
    Inventors: Meike Eickhoff, Eberhard Russmann, Andreas Woelfelschneider, Dirk Zimmerman
  • Publication number: 20180142282
    Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.
    Type: Application
    Filed: June 30, 2017
    Publication date: May 24, 2018
    Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
  • Patent number: 9920354
    Abstract: The present invention is in the field of in-vitro diagnostics. Within this field, it provides the amplification of at least a first target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer. It further provides an analytical system comprising an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: March 20, 2018
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Meike Eickhoff, Eberhard Russmann, Andreas Woelfelschneider, Dirk Zimmermann
  • Publication number: 20170268074
    Abstract: A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single none-degenerate forward primer partially overlapping the 5?UTR region of HEV and at least one reverse primer. Also disclosed are related methods comprising a probe, and kits for the detection of genotypes 1, 2, 3 and/or 4 of HEV.
    Type: Application
    Filed: June 2, 2017
    Publication date: September 21, 2017
    Inventors: Hermann Leying, Thomas W. Myers, Nicolas Newton, Eberhard Russmann, Joseph San Filippo, Nancy Schoenbrunner, Heike Wilts, Xiaoning Wu, Karen K. Y. Young, Dirk Zimmermann
  • Patent number: 9725754
    Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: August 8, 2017
    Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
  • Patent number: 9702017
    Abstract: A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single none-degenerate forward primer partially overlapping the 5?UTR region of HEV and at least one reverse primer. Also disclosed are related methods comprising a probe, and kits for the detection of genotypes 1, 2, 3 and/or 4 of HEV.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: July 11, 2017
    Inventors: Hermann Leying, Thomas W. Myers, Nicolas Newton, Eberhard Russmann, Joseph San Filippo, Nancy Schoenbrunner, Heike Wilts, Xiaoning Wu, Karen K. Y. Young, Dirk Zimmermann
  • Publication number: 20130280697
    Abstract: A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single none-degenerate forward primer partially overlapping the 5?UTR region of HEV and at least one reverse primer. Also disclosed are related methods comprising a probe, and kits for the detection of genotypes 1, 2, 3 and/or 4 of HEV.
    Type: Application
    Filed: April 17, 2013
    Publication date: October 24, 2013
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Hermann Leying, Thomas W. Myers, Nicolas Newton, Eberhard Russmann, Joseph San Filippo, Nancy Schoenbrunner, Heike Wilts, Xiaoning Wu, Karen K. Y. Young, Dirk Zimmermann
  • Publication number: 20120190010
    Abstract: The present invention belongs to the field of in-vitro diagnostics. Within this field, it particularly concerns the amplification of at least a first target nucleic acid that may be present in at least one fluid sample using an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer. It further provides an analytical system comprising an internal control nucleic acid for qualitative and/or quantitative purposes and at least one external control nucleic acid in an aqueous buffer.
    Type: Application
    Filed: December 16, 2011
    Publication date: July 26, 2012
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Meike Eickhoff, Eberhard Russmann, Andreas Woelfelschneider, Dirk Zimmermann
  • Patent number: 8192958
    Abstract: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to a method for the detection of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof, optionally isolating the nucleic acid, optionally amplifying the nucleic acid, and detecting the nucleic acid. The invention is further related to a method for the purification of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof and isolating the nucleic acid thereby purifying the nucleic acid.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: June 5, 2012
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Sigrid Adie, Hermann Leying, Nicole Nachbaur, Eberhard Russmann
  • Publication number: 20120100599
    Abstract: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to a method for the detection of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof, optionally isolating the nucleic acid, optionally amplifying the nucleic acid, and detecting the nucleic acid. The invention is further related to a method for the purification of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof and isolating the nucleic acid thereby purifying the nucleic acid.
    Type: Application
    Filed: December 8, 2011
    Publication date: April 26, 2012
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Sigrid Adie, Hermann Leying, Nicole Nachbaur, Eberhard Russmann
  • Publication number: 20120045751
    Abstract: The present invention relates to the sample preparation of nucleic acids for diagnostic purposes. More precisely, the invention provides a process for simultaneously isolating at least a first and a second target nucleic acid from a plurality of different types of fluid samples and optionally amplifying said isolated nucleic acids in a simultaneous manner.
    Type: Application
    Filed: July 27, 2011
    Publication date: February 23, 2012
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Sean F. Boyle, Meike Eickhoff, Christopher Newhouse, Eberhard Russmann, Edward S. Smith, Andreas Woelfelschneider, Dirk Zimmermann
  • Patent number: 8097717
    Abstract: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to a method for the detection of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof, optionally isolating the nucleic acid, optionally amplifying the nucleic acid, and detecting the nucleic acid. The invention is further related to a method for the purification of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof and isolating the nucleic acid thereby purifying the nucleic acid.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: January 17, 2012
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Sigrid Adie, Hermann Leying, Nicole Nachbaur, Eberhard Russmann
  • Publication number: 20110311982
    Abstract: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to a method for the detection of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof, optionally isolating the nucleic acid, optionally amplifying the nucleic acid, and detecting the nucleic acid. The invention is further related to a method for the purification of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof and isolating the nucleic acid thereby purifying the nucleic acid.
    Type: Application
    Filed: August 24, 2011
    Publication date: December 22, 2011
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Sigrid Adie, Hermann Leying, Nicole Nachbaur, Eberhard Russmann
  • Publication number: 20100173353
    Abstract: Subject matter of the invention is a lysis reagent formulation for binding components of a sample in the form of a tablet comprising a multitude of magnetic particles which are held together with the aid of excipients, a chaotropic salt and an excipient and the use of this lysis reagent formulation in analytical tests.
    Type: Application
    Filed: July 8, 2009
    Publication date: July 8, 2010
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Stephanie Koennings, Leif Kuhler, Eberhard Russmann, Katja Schuster, Edward S. Smtih
  • Publication number: 20080187905
    Abstract: This invention relates to a composition comprising a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof. The invention is further related to uses of this composition and to a kit comprising the composition according to the invention. The invention is further related to a method for the detection of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof, optionally isolating the nucleic acid, optionally amplifying the nucleic acid, and detecting the nucleic acid. The invention is further related to a method for the purification of a nucleic acid in a biological sample comprising the steps of incubating the biological sample in the presence of a chaotropic agent, a buffering substance, and 0.5 to 5% (V/V) polidocanol or a derivative thereof and isolating the nucleic acid thereby purifying the nucleic acid.
    Type: Application
    Filed: December 11, 2007
    Publication date: August 7, 2008
    Applicant: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Sigrid Adie, Hermann Leying, Nicole Nachbaur, Eberhard Russmann
  • Patent number: 6538110
    Abstract: The invention concerns an antibody composition which inhibits the binding of interleukin 2 to its high affinity receptor and contains (1) monoclonal antibodies against the &agr; chain of the interleukin 2 receptor and (2) monoclonal antibodies against the &bgr; chain of the interleukin 2 receptor, as well as a pharmaceutical agent which contains the antibody composition according to the present invention.
    Type: Grant
    Filed: March 10, 1993
    Date of Patent: March 25, 2003
    Assignee: Roche Diagnostics
    Inventors: Ulrich Weidle, Eberhard Russmann, Klaus-Peter Hirth, Tiberiu Diamantstein, Brigitte Kaluza
  • Patent number: 5700639
    Abstract: The invention concerns a method for the non-radioactive detection of metabolically labelled DNA, in one aspect detecting labelled DNA indicative of cell lysis or apoptosis.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: December 23, 1997
    Assignee: Boehringer Mannheim GmbH
    Inventors: Bernhard Trauth, Matthias Hinzpeter, Clemens Doppler, Eberhard Russmann