Abstract: The invention relates to the use of compounds of a general formula (I), wherein R2, R14 to R17 and X groups have the following significance: R2 is C1-C5-Alkyl, C1-C5-Alkoxy or a —O—C<SB>N</SB>FmHo rest, wherein n=1,2,3,4,5 or 6, m>1 and m+o=2n+1, R14 and R15 separately designate hydrogen or together a methyl group or a supplementary liaison, R16 is hydrogen; R17 is hydrogen, hydroxy, C1-C5-Alkyl, C1-C5-Alkoxy or SO3NHX; X is hydrogen, C1-C5-alkyl or C1-C5 acyl. In the cycle B and D of a steroid skeleton, stippled lines can additionally represent up to two double bonds. The salts of said compounds which are pharmaceutically acceptable for preparing a drug are also disclosed.

Abstract: The invention relates to the use of 2-substituted estra-1,3,5(10)-triene-3-yl sulfamates of general formula I, in addition to their pharmaceutically acceptable salts for producing a medicament Said compounds have an anti-tumour action.

Abstract: Method for examining active ingredients for influencing intracellular processes, wherein at least one active ingredient is added to an assembly equilibrium of proteins capable of assembly and a first fluorescence correlation measurement (FCS) is carried out after the addition of fluorescence-labeled monomers and/or dimers.

Abstract: The present invention relates to the use of 2-alkoxyestrogen sulfamates of general formula I 1

Abstract: The present invention relates to an oligonucleotide or a derivative thereof which has a sequence that corresponds to a particular fragment of a nucleic acid sequence which encodes human eg5 or a mutant form thereof; the invention further relates to a method of making the oligonucleotide and the use thereof.

Abstract: A drive shield for driving wide underground cavities comprises a plurality of knife shields arranged side-by-side transversely of the direction of advance. Each knife shield has a plurality of elongate knives displaceably mounted on a respective support frame. The elongate knives are advanceable relative to their support frame by means of hydraulic rams mounted on that support frame. The support frames of each pair of adjacent knife shields are linked by connecting means such as double-acting hydraulic rams, which permit one of the support frames to be advanced relative to the other.

Abstract: Apparatus for use in tunnel driving employs a drive shield of known type with elongate drive members arranged side-by-side and supported and guided by a rigid frame. Hydraulic rams are used to alternately advance individual members or groups of members and the frame. Fluid concrete is introduced behind the shield to form a permanent lining supported by formwork and sealed to the tunnel wall by sheet material. The fluid concrete is contacted during its setting period by a hollow ring member of the formwork. The ring member is provided with a filter structure permitting water to be withdrawn by suction. Further separate hydraulic rams interconnect the ring member and the frame of the drive shield enabling the fluid concrete to be compressed. Some of the drive members have prolonged thin rear extensions which form tails extending partly around the concreting zone in contact with the tunnel wall.

Abstract: Conveying apparatus which may be embodied as a jib for a cutter-loader machine in tunnelling or mining applications. The apparatus employs a scraper-chain assembly which in known manner is entrained around rotatable members and is circulated within guide channels with side surfaces adjoined by a base or floor surface. An electric drive motor is coupled via reduction-ratio gearing unit to one or other of the rotatable members. The motor and the gearing each have housings joined together end-to-end and the housing of the motor is joined to at least one other body section of the apparatus. The housings and this body section have the same cross-sectional profile defining the aforesaid guide channels.