Abstract: Head and neck squamous cell carcinomas (HNSCC) represent a group of metastasizing tumors with a high mortality rate in man and animals. Since the biomolecule ozone was found to inhibit growth of various carcinoma cells in vitro we here applied the highly aggressive and lethal VX2 carcinoma HNSCC tumor model of the New Zealand White rabbit to test whether ozone exerts anti-tumorous effects in vivo. Therapeutic insufflation of medical ozone/oxygen (O3/O2) gas mixture into the peritoneum (O3/O2-pneumoperitoneum) at an advanced stage of tumor disease led to a survival rate of 7/14 rabbits. Six of the seven surviving rabbits presented full tumor regression and the absence of local or distant lung metastases. Insufflation of pure oxygen (O2) resulted in a survival rate of 3/13 animals accompanied by full tumor remission in two of the three surviving animals. Of the fourteen sham-treated animals only one had spontaneous tumor remission and survived.

Abstract: Head and neck squamous cell carcinomas (HNSCC) represent a group of metastasizing tumors with a high mortality rate in man and animals. Since the biomolecule ozone was found to inhibit growth of various carcinoma cells in vitro we here applied the highly aggressive and lethal VX2 carcinoma HNSCC tumor model of the New Zealand White rabbit to test whether ozone exerts anti-tumorous effects in vivo. Therapeutic insufflation of medical ozone/oxygen (O3/O2) gas mixture into the peritoneum (O3/O2-pneumoperitoneum) at an advanced stage of tumor disease led to a survival rate of 7/14 rabbits. Six of the seven surviving rabbits presented full tumor regression and the absence of local or distant lung metastases. Insufflation of pure oxygen (O2) resulted in a survival rate of 3/13 animals accompanied by full tumor remission in two of the three surviving animals. Of the fourteen sham-treated animals only one had spontaneous tumor remission and survived.

Abstract: VGLUT-specific dsRNAs capable of triggering the phenomenon of RNA interference, host cells containing theses dsRNAs, and pharmaceutical compositions containing these dsRNAs, in particular for the treatment of pain and other diseases associated with VGLUT family members.

Abstract: A nucleic acid comprising a sequence section which modulates the expression of the VR1 receptor, a vector containing this nucleic acid and a host cell which is transformed with this vector are disclosed, along with related pharmaceutical formulations. Methods for modulating the expression of the VR1 receptor and the use of the nucleic acid or vector for alleviating, preventing or treating pain and for treating sensibility disorders associated with the VR1 receptor are also provided.

Abstract: Methods for finding and screening for pharmaceutically active substances using BNPI and/or DNPI or biomolecules derived therefrom, and compounds identified thereby and their use. Also provided are active substances that bind to BNPI and/or DNPI, antibodies directed against BNPI and/or DNPI, antisense nucleotides against BNPI and/or DNPI, or BNPI and/or DNPI or partial proteins thereof, or of corresponding polynucleotides, in the preparation of pharmaceutical formulations for the treatment of various diseases or for related methods of treatment and diagnostics.

Abstract: Methods for detecting pain-regulating substances using BNPI and/or DNPI and the use of compounds thereby identified, active compounds which bind to BNPI and/or DNPI, antibodies directed against BNPI and/or DNPI, antisense nucleotides against BNPI and/or DNPI, or BNPI and/or DNPI or part proteins thereof, and corresponding polynucleotides for pharmaceutical formulations for pain therapy and diagnostic agents are provided. Certain nucleotide sequences, proteins and part proteins are also provided.

Abstract: Methods for detecting pain-relevant substances using PIM-1-kinase or PIM-3-kinase are provided. Methods of using such substances, as well as antibodies and antisense nucleotides against PIM-1-kinase or PIM-3-kinase, for instance, in pharmaceutical compositions, diagnostic agents, and in pain therapy are also provided. Certain nucleotide sequences, proteins, and part proteins are also provided.