Patents by Inventor Ebrahim Zandi
Ebrahim Zandi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110287440Abstract: The invention provides a means for reconstituting I?B kinase in yeast in order to study the structure and regulation of IKK and to produce pharmacological therapies to block IKK. This invention can be used to express an IKK complex that is biochemically identical to IKK isolated from native cells and in coupled in vitro kinase assays to screen for its upstream regulators. The IKK expressed by reconstituting the yeast can be used to screen for unknown substrates and for pharmacological therapies that block its activity. The invention could also be used to screen for compounds that enhance its activity. The IKK may also be used as a source of material for crystallization and X-ray diffraction analysis.Type: ApplicationFiled: August 1, 2011Publication date: November 24, 2011Inventors: Ebrahim Zandi, Beth Schomer Miller
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Publication number: 20100055714Abstract: The present invention provides an isolated nucleic acid molecules encoding I?B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I?B) that inhibits the activity of the NF-?B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I?B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: ApplicationFiled: October 31, 2007Publication date: March 4, 2010Inventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Patent number: 7314615Abstract: The present invention provides an isolated nucleic acid molecules encoding I?B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I?B) that inhibits the activity of the NF-?B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I?B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: GrantFiled: December 17, 2003Date of Patent: January 1, 2008Assignee: The Regents of the University of CaliforniaInventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Publication number: 20070166812Abstract: The present invention provides a novel essential regulatory subunit of the I?B kinase (IKK) complex, IKK-?. The isolated IKK-? subunit of the invention has substantially the same amino acid sequence as SEQ ID NO: 2 shown in FIG. 2.Type: ApplicationFiled: March 9, 2007Publication date: July 19, 2007Applicant: The Regents of the University of CaliforniaInventors: Michael Karin, David Rothwarf, Ebrahim Zandi
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Patent number: 7189832Abstract: The present invention provides a novel essential regulatory subunit of the I?B kinase (IKK) complex, IKK-?. The isolated IKK-? subunit of the invention has substantially the same amino acid sequence as SEQ ID NO: 2 shown in FIG. 2.Type: GrantFiled: August 20, 1999Date of Patent: March 13, 2007Assignee: The Regents of the University of CaliforniaInventors: Michael Karin, David M. Rothwarf, Ebrahim Zandi
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Publication number: 20040228849Abstract: The present invention provides an isolated nucleic acid molecules encoding IKB kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I&kgr;B) that inhibits the activity of the NF-&kgr;B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I&kgr;B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: ApplicationFiled: December 17, 2003Publication date: November 18, 2004Inventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Patent number: 6689575Abstract: The present invention provides an isolated nucleic acid molecules encoding I&kgr;B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I&kgr;B) that inhibits the activity of the NF-&kgr;B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I&kgr;B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: GrantFiled: February 28, 2001Date of Patent: February 10, 2004Assignee: The Regents of the University of CaliforniaInventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Publication number: 20030054450Abstract: The invention provides a means for reconstituting I&kgr;B kinase in yeast in order to study the structure and regulation of IKK and to produce pharmacological therapies to block IKK. This invention can be used to express an IKK complex that is biochemically identical to IKK isolated from native cells and in coupled in vitro kinase assays to screen for its upstream regulators. The IKK expressed by reconstituting the yeast can be used to screen for unknown substrates and for pharmacological therapies that block its activity. The invention could also be used to screen for compounds that enhance its activity. The IKK may also be used as a source of material for crystallization and X-ray diffraction analysis.Type: ApplicationFiled: February 19, 2002Publication date: March 20, 2003Applicant: University of Southern CaliforniaInventors: Ebrahim Zandi, Beth Schomer Miller
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Publication number: 20020045235Abstract: The present invention provides an isolated nucleic acid molecules encoding I&kgr;B kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (I&kgr;B) that inhibits the activity of the NF-&kgr;B transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an I&kgr;B protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: ApplicationFiled: February 28, 2001Publication date: April 18, 2002Inventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Patent number: 6268194Abstract: The present invention provides a substantially purified nucleic acid molecule encoding a serine protein kinase (I&kgr;B kinase) that phosphorylates a protein (I&kgr;B) that inhibits the activity of the NF-&kgr;B transcription factor, vectors comprising such a nucleic acid molecule and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides a substantially purified I&kgr;B kinase, which is a polypeptide that can phosphorylate an I&kgr;B protein, and peptide portions of the I&kgr;B kinase. In addition, the invention provides anti-I&kgr;B kinase antibodies, which specifically bind to an I&kgr;B kinase, and I&kgr;B kinase-binding fragments of such antibodies.Type: GrantFiled: February 25, 1997Date of Patent: July 31, 2001Assignee: The Regents of the University of CaliforniaInventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi
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Patent number: 6242253Abstract: The present invention provides an isolated nucleic acid molecules encoding IKB kinase (IKK) catalytic subunit polypeptides, which are associated with an IKK serine protein kinase that phosphorylates a protein (IKB) that inhibits the activity of the NF-KB transcription factor, vectors comprising such nucleic acid molecules and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides isolated IKK catalytic subunits, which can phosphorylate an IKB protein, and peptide portions of such IKK subunit. In addition, the invention provides anti-IKK antibodies, which specifically bind to an IKK complex or an IKK catalytic subunit, and IKK-binding fragments of such antibodies.Type: GrantFiled: October 8, 1998Date of Patent: June 5, 2001Assignee: Regents of the University of CaliforniaInventors: Michael Karin, Joseph A. DiDonato, David M. Rothwarf, Makio Hayakawa, Ebrahim Zandi