Abstract: An infrared (IR) radiation sensor for detection of an analyte in a fluid. The IR sensor comprises: i) a housing; ii) a reservoir disposed in the housing and configured to contain the fluid; iii) a fluid channel in communication with the reservoir; and iv) a preconcentration material associated with the fluid channel. The preconcentration material enhances IR bands in an IR spectra. The IR sensor also includes a photonic integrated circuit disposed in the housing. The photonic integrated circuit includes an IR source configured to transmit IR light toward the fluid channel and the preconcentration material. A spectral characteristic of the IR light is changed by the analyte in the fluid in the fluid channel that is trapped in the preconcentration material. The photonic IC also includes an IR detector configured to receive IR light transmitted through or reflected off the preconcentration material and detect the spectral characteristic.