Patents by Inventor Eckart Grabenhorst

Eckart Grabenhorst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hasylated polypeptides
    Patent number: 8618266
    Abstract: The present invention relates to hydroxyalkylstarch (HAS)-polypeptide-conjugate (HAS-polypeptide) comprising one or more HAS molecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as to methods for the production thereof. In a preferred embodiment, the polypeptide is erythropoietin (EPO).
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: December 31, 2013
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Harald S. Conradt, Eckart Grabenhorst, Manfred Nimtz, Norbert Zander, Ronald Frank, Wolfram Eichner
  • Production of bioactive glycoproteins from inactive starting material
    Publication number: 20100062973
    Abstract: A method for preparing a conjugate comprising a glycoprotein and a polymer or a derivative of said polymer, wherein the polymer is a hydroxyalkylstarch (HAS), the method comprising the steps a) reacting said glycoprotein with a modified polyol carrying attached thereto, by a covalent linkage, a functional group Z, in the presence of a transferase capable of catalysing formation of a covalent linkage between the glycoprotein and said modified polyol, yielding a glycoprotein covalently linked to a polyol carrying attached thereto, by a covalent linkage, at least one functional group Z, and b) reacting at least one functional group A of the polymer or the derivative thereof with the at least one functional group Z of the glycoprotein added to said glycoprotein during step a), and thereby forming a covalent linkage.
    Type: Application
    Filed: March 9, 2006
    Publication date: March 11, 2010
    Applicant: FRESENIUS KABI DEUTSCHLAND GmbH
    Inventors: Ronald Frank, Harald S. Conradt, Eckart Grabenhorst, Norbert Zander
  • Hasylated polypeptides
    Publication number: 20060019877
    Abstract: The present invention relates to hydroxyalkylstarch (HAS)-polypeptide-conjugate (HAS-polypeptide) comprising one or more HAS molecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as to methods for the production thereof. In a preferred embodiment, the polypeptide is erythropoietin (EPO).
    Type: Application
    Filed: March 11, 2005
    Publication date: January 26, 2006
    Inventors: Harald Conradt, Eckart Grabenhorst, Manfred Nimtz, Norbert Zander, Ronald Frank, Wolfram Eichner