Abstract: A single-use bioreactor, suitable in particular for use in a parallel bioreactor system for applications in cell culture and/or microbiology, a head plate for such a single-use bioreactor and a process for manufacturing the single-use bioreactor and the head plate. The single-use bioreactor comprises a head plate, a dimensionally stable container and a mixer, the head plate and the container enclosing a reaction chamber, and the mixer having a mixer shaft and a stirring member, said mixer shaft being mounted rotatably about a rotational axis in a bearing and the stirring member being fastened torsionally rigidly to the mixer shaft. The mixer and the bearing are arranged entirely within the reaction chamber and the mixer shaft has a magnetic portion which is arranged and adapted in such a way that it can be coupled magnetically in an axial direction to a rotary drive.

Abstract: A centrifuge bucket for centrifuging materials, in particular in laboratory centrifuges. The centrifuge bucket is operable in a very simple manner and facilitates safe and constant closure over the service life of the centrifuge bucket. Thus, the centrifuge bucket handles much better than known centrifuge buckets because real one hand operation without using a second hand is facilitated. Furthermore, the centrifuge bucket can be produced in a simpler and more cost-effective manner while being equally suitable for a given centrifugation power and centrifugation capacity.

Abstract: The method relates to the co-culturing of two cell cultures in two cell culture chambers such that the cellular products produced by the co-cultured cells are exchanged between the two cell culture chambers. The apparatus for culturing the cells contains two cell culture chambers separated by a microfiltration membrane which is permeable to medium, gases, and cellular products, and is impermeable to cells. A culture medium supply chamber is adjacent to and separated from the first cell culture chamber by a dialysis membrane which is permeable to medium and gases. The exterior portion of the second cell culture contains a gas-exchange membrane which allows gas exchange between the apparatus and the environment. The apparatus can be in a modular form where the first and second cell culture chambers form one module which is detachable from the culture medium supply chamber which forms the second module.

Abstract: The purpose of the present invention is to attain optimal gas exchange, nutrient supply and disposal of metabolic waste products without contamination during high-density cell cultivation of adherent cells. The culture vessel of the present invention provides methods and apparatus for the cultivation of cells on a three-dimensional carrier in a closed cell culture chamber, the supply with oxygen taking place across a gas-permeable gas exchange membrane bordering the cell culture chamber and the supply with nutrients taking place across a dialysis membrane bordering the cell culture chamber, across which nutrients are transported and across which metabolic products are removed, without the danger of contaminating the cells during contact with the tools necessary for manually separating the cells being cultivated from the nutrient medium. The cell culture chamber of the present invention features a vessel that is impermeable to fluids on all sides except for the boundary formed by the dialysis membrane.

Abstract: To eliminate welds when forming connections from coupling joints of membrane filter structures having two external housing plates between which a membrane filter assembly (3, 4) is positioned, one (2) of the housing plates (1, 2) is formed with a bored or milled, essentially circular recess at each one of the locations where fluid connection couplings (6-9) are to be placed, the fluid connection couplings being formed by a plug element which is clamped in sealing engagement against a sealing bottom wall surface (13) of the respective recess. To provide absolute tightness, even of molecular substances such as bacteria, tissue elements, yeasts and the like, a sealing ring, preferably an O ring (15) is placed in a groove (14) formed in the sealing wall surface (13).

Abstract: A latch is known for a laboratory apparatus, for locking a cover or door on its housing, having a hook 12 in one of the parts to be locked and a lock 1 in the other. The lock has a pivotable locking element 3 with a claw-shaped opening 9 which engages the hook 12 against the pressure of a spring and is releasable from engagement with the hook by an actuating element 7. In order to provide a latch of this kind with means to meet strict safety requirements and ensure secure locking during operation of the apparatus, an additional closing element 4, opening element 5, and securing element 6, which engage one another, are disposed between the locking element 3 and the actuating element 7.