Patents by Inventor Eckhard Alt

Eckhard Alt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10918672
    Abstract: A method of curing (or at least treating) HIV, by obtaining small tissue mesenchymal stem cells (stMSC) from adipose tissue of a patient with HIV or from a syngeneic donor or an immuno-compatible donor, wherein said stMSC are i) 4-6 ?m in diameter, ii) pluripotent, and iii) have CD11b?, CD34?, CD45?, CD 29, CD 49, Oct 4 and SSEA 4 surface markers when harvested. Preferred sources are autologous adipose tissue. Next those stMSCs are gene edited to provide CCR5? stMSCs and optionally amplified by growth in culture and/or by cell selection for gene edited stMSCs and then re-introducing into the patient. Preferably, the CCR5? stMSCs will re-populate the patient with stem cells that can no longer act as latent HIV reservoirs and can differentiate into immune cells that are HIV resistant. If desired, the patient can be first treated, e.g., by radiation, to destroy the bone marrow cells before the re-introduction.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: February 16, 2021
    Assignee: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
    Inventors: Stephen E. Braun, Reza Izadpanah, Eckhard Alt
  • Patent number: 10905722
    Abstract: Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
    Type: Grant
    Filed: March 7, 2018
    Date of Patent: February 2, 2021
    Assignees: INGENERON INC., ALLIANCE OF CARDIOVASCULAR RESEARCHERS
    Inventors: Eckhard Alt, Tahereh Karimi
  • Patent number: 10538767
    Abstract: Treatment of tumors, especially breast cancer or glioblastoma tumors, by silencing RAB27A and/or TRAF3IP2, compositions and methods for same.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: January 21, 2020
    Assignee: The Administrators of the Tulane Educational Fund
    Inventors: Eckhard Alt, Reza Izadpanah
  • Publication number: 20190078092
    Abstract: Treatment of tumors, especially breast cancer or glioblastoma tumors, by silencing RAB27A and/or TRAF3IP2, compositions and methods for same.
    Type: Application
    Filed: November 26, 2018
    Publication date: March 14, 2019
    Inventors: Eckhard Alt, Reza Izadpanah
  • Patent number: 10137143
    Abstract: Treatment of tumors, especially breast cancer or glioblastoma tumors, by silencing RAB27A and/or TRAF3IP2, compositions and methods for same.
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: November 27, 2018
    Assignee: The Administrators of the Tulane Educational Fund
    Inventors: Eckhard Alt, Reza Izadpanah
  • Publication number: 20180264046
    Abstract: Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
    Type: Application
    Filed: March 7, 2018
    Publication date: September 20, 2018
    Inventors: Eckhard ALT, Tahereh KARIMI
  • Patent number: 9913865
    Abstract: Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: March 13, 2018
    Assignees: InGeneron Inc., Alliance of Cardiovascular Research
    Inventors: Eckhard Alt, Tahereh Karimi
  • Patent number: 9775532
    Abstract: A system and method for communicating data and signals through the Medical Implant Communication Service Band using a repeater or base station in the proximity to an implantable device within a patient is disclosed. In a preferred embodiment, the device is capable for early detection and monitoring of congestive heart failure in a patient. Impedance measurements, or other health parameters depending on the type of implantable device or sensor used, are sent using a bi-directional low-power radio operating in the MICS band to a nearby base station which may provide signal processing and analysis. The base station may have an interface to one or more communications networks to connect to a remote location. The system and method of the present invention permits a healthcare professional to monitor an ambulatory patient's condition at a remote location and to program the implanted device.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: October 3, 2017
    Assignee: Medtronic, Inc.
    Inventors: Eckhard Alt, John Philip Brinkmann
  • Publication number: 20170182099
    Abstract: Adult stem cells are reprogrammed to form pacemaker cells and Purkinje cells through the sequential activation of SHOX2>TBX5>HCN2. These Purkinje cells spontaneously surround and connect with the larger pacemaker cells, thus forming an induced sinoatrial body that produces funny current and can make cardiovascular tissues beat in a manner similar to a natural sinoatrial node.
    Type: Application
    Filed: December 28, 2015
    Publication date: June 29, 2017
    Inventors: Eckhard ALT, Tahereh KARIMI
  • Publication number: 20170166868
    Abstract: A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The inventive culture media, media supplement, or soluble matrix comprises a GAG composition comprising a sulfated GAG, such as chondroitin sulfate. A soluble matrix, a cell administration package or kit comprising the soluble matrix and a device for cell administration, and a method of use thereof, for administration of regenerative cells for treating a joint disease or other weakened or damaged tissue comprising the specified GAG compositions are further provided.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 15, 2017
    Inventors: Michael Coleman, Ivone Bruno, Rudy Martinez, Amir Sanchez, Eckhard Alt, Frank D. Marcum, Paul Shealy
  • Patent number: 9593309
    Abstract: A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The inventive culture media, media supplement, or soluble matrix comprises a GAG composition comprising a sulfated GAG, such as chondroitin sulfate. A soluble matrix, a cell administration package or kit comprising the soluble matrix and a device for cell administration, and a method of use thereof, for administration of regenerative cells for treating a joint disease or other weakened or damaged tissue comprising the specified GAG compositions are further provided.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: March 14, 2017
    Assignees: ArthroDynamic Holdings, LLC, InGeneron Incorporated
    Inventors: Michael Coleman, Ivone Bruno, Rudy Martinez, Amir Sanchez, Eckhard Alt, Frank D. Marcum, Paul Shealy
  • Publication number: 20160272943
    Abstract: A closed system apparatus and method for isolation and recovery of desired cells from body tissue includes a first container for tissue dissociation by subjection to centrifugation over one or more cycles of rotational acceleration and deceleration, a particle filter to filter out non-dissociated tissue while passing desired cells to a second container for separating the desired cells from connective tissue, unwanted material, liquid, and dissociation-aiding reagent(s) by subjection of the second container to combined centrifugal and gravitational forces that also causes concentration and sedimentation of the cells into a pellet for removal through a valve in the bottom of the second container.
    Type: Application
    Filed: December 15, 2015
    Publication date: September 22, 2016
    Inventors: Greg Stone, Ron Stubbers, Michael E. Coleman, Eckhard Alt
  • Patent number: 9447379
    Abstract: Methods and compositions for differentiating tissue resident multipotent mesenchmal stromal cells (MSCs) such as adipose tissue resident MSCs into a hematopoietic lineage are described.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: September 20, 2016
    Inventors: Reza Izadpanah, Eckhard Alt
  • Publication number: 20160158292
    Abstract: Methods for the extraction and processing of umbilical stem cells for therapeutic and diagnostic purposes are disclosed. The methods provide high regenerative cell numbers and high cell viability. Further, the methods do not require culturing the cells in serum or growth factors.
    Type: Application
    Filed: July 31, 2015
    Publication date: June 9, 2016
    Applicant: Ingeneron, Inc.
    Inventors: Eckhard Alt, Ivonne Guzman Bruno, Timo Nazari Shafti, Michael E Coleman, Anita Kadala
  • Patent number: 9310300
    Abstract: A structure is configured to retain optical diagnostic assay components in a manner that enables them to be synergistically combined or coupled both mechanically and electrically with a conventional mobile electronic device (such as a smartphone), such that the pairing maintains a mutually advantageous relationship to provide a compact portable optical assay apparatus in which the optical assay portion has access to the image sensor, battery power, microprocessor, and data capture, analysis, storage, display and transmission capabilities of the smartphone, and the smartphone portion provides the overall apparatus with features of transportability, user interface, and information storage, analysis and retrieval, and transmission of assay results to a separate site, such as a site of records related to the provider of the sample being assayed. Methods of providing such structure and of performing an optical assay of sample material utilizing such structure are described.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: April 12, 2016
    Assignee: INGENERON INCORPORATED
    Inventors: Eckhard Alt, Jody Vykoukal, Michael Coleman
  • Patent number: 9242069
    Abstract: A method is described for repairing tissue of a selected organ from among heart, brain, liver, pancreas, kidney, and glands in a patient's body. In the method, stem cells that have the capability to repair tissue of the selected organ are intraluminally applied through a designated natural body vessel or duct leading to a predetermined target site of the tissue of the selected organ to be repaired. The stem cells are delivered into the respective vessel or duct through a catheter having a proximal portion of relatively larger central lumen diameter and outer diameter, and a distal portion of relatively smaller central lumen diameter and outer diameter, the two portions being integral with one another so that stem cells delivered into the central lumen of the proximal portion will flow through and exit the central lumen of the distal portion, the lumen diameter and length of each of the two portions being selected to minimize the pressure drop across the catheter during flow of the stem cells.
    Type: Grant
    Filed: February 28, 2005
    Date of Patent: January 26, 2016
    Assignee: SCICOTEC GmbH
    Inventors: Eckhard Alt, Kai Pinkernell, Russ Auger
  • Publication number: 20150240211
    Abstract: A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The inventive culture media, media supplement, or soluble matrix comprises a GAG composition comprising a sulfated GAG, such as chondroitin sulfate. A soluble matrix, a cell administration package or kit comprising the soluble matrix and a device for cell administration, and a method of use thereof, for administration of regenerative cells for treating a joint disease or other weakened or damaged tissue comprising the specified GAG compositions are further provided.
    Type: Application
    Filed: May 8, 2015
    Publication date: August 27, 2015
    Inventors: Michael Coleman, Ivone Bruno, Rudy Martinez, Amir Sanchez, Eckhard Alt, Frank D. Marcum, Paul Shealy
  • Patent number: 8777851
    Abstract: An implanted device-implemented method of detecting and monitoring congestive heart failure in a patient includes performing ongoing measurements of changes in local impedance of a portion of the patient's body between at least two electrodes on the exterior of the implanted device, the changes representing ventilation of the patient, and including measuring the patient's respiratory rate and respiratory amplitude. A body-implantable device is adapted to detect and monitor congestive heart failure in a patient, and includes a circuit module coupled to plural surface electrodes of the device arranged and adapted, when the device is implanted, for contacting tissue in a portion of the patient's body generally occupied by the lungs, to monitor changes in local impedance of said body portion, and to detect the patient's EKG.
    Type: Grant
    Filed: July 16, 2003
    Date of Patent: July 15, 2014
    Assignee: Medtronic, Inc.
    Inventor: Eckhard Alt
  • Patent number: 8781587
    Abstract: A device is presented for evaluating whether an episode of sleep apnea is occurring in a patient suffering from chronic sleep apnea disorder, for delivery of appropriate therapy. The device includes circuitry adapted to respond to a cardiac signal generated by the heart. Switching circuitry diverts passage of the heart signal through both a high impedance path and a substantially lower impedance path, and a differential amplifier processes the resulting signal pairs to ascertain the difference in magnitude between the two signals of each pair. An analyzer thereof determines changes in the patient's ventilation, from which inordinately reduced patient ventilation is detected to assess possible occurrence of an episode of sleep apnea. If the analyzer denotes change of ventilation between otherwise regular respiratory cycles, an actual episode of sleep apnea is indicated.
    Type: Grant
    Filed: January 19, 2013
    Date of Patent: July 15, 2014
    Inventors: Eckhard Alt, Maik Gollasch
  • Publication number: 20140038222
    Abstract: A structure is configured to retain optical diagnostic assay components in a manner that enables them to be synergistically combined or coupled both mechanically and electrically with a conventional mobile electronic device (such as a smartphone), such that the pairing maintains a mutually advantageous relationship to provide a compact portable optical assay apparatus in which the optical assay portion has access to the image sensor, battery power, microprocessor, and data capture, analysis, storage, display and transmission capabilities of the smartphone, and the smartphone portion provides the overall apparatus with features of transportability, user interface, and information storage, analysis and retrieval, and transmission of assay results to a separate site, such as a site of records related to the provider of the sample being assayed. Methods of providing such structure and of performing an optical assay of sample material utilizing such structure are described.
    Type: Application
    Filed: April 3, 2013
    Publication date: February 6, 2014
    Inventors: Eckhard Alt, Jody Vykoukal, Michael Coleman