Patents by Inventor Eckhard Günther

Eckhard Günther has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyridopyrazines and the use thereof as kinase inhibitors
    Patent number: 7276507
    Abstract: The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general Formula I, their preparation and use as medicaments, in particular for the treatment of malignant and other disorders based on pathological cell proliferations
    Type: Grant
    Filed: May 21, 2004
    Date of Patent: October 2, 2007
    Assignee: AEterna Zentaris GmbH
    Inventors: Eckhard Claus, Eckhard Günther, Irene Seipelt, Ulf R. Rapp, Ludmilla Wixler
  • NOVEL PYRIDOPYRAZINES AND THEIR USE AS MODULATORS OF KINASES
    Publication number: 20070149484
    Abstract: The invention relates to novel pyrido[2,3-b]pyrazine derivatives of the general formulae (I) and (II), and to their preparation and use as medicaments, especially for the treatment of malignant disorders and other disorders based on pathological cell proliferations.
    Type: Application
    Filed: November 10, 2006
    Publication date: June 28, 2007
    Applicant: ZENTARIS GmbH
    Inventors: Eckhard Claus, Irene Seipelt, Eckhard Guenther, Emmanuel Polymeropoulos, Michael Czech, Tilmann Schuster
  • PYRIDOPYRAZINE DERIVATIVES AND THEIR USE
    Publication number: 20070123494
    Abstract: The present invention provides new pyridopyrazine compounds which are suitable for the treatment or prevention of physiological and/or pathophysiological states mediated and/or modulated by signal transduction pathways and/or enzymes in mammals and in particular in humans.
    Type: Application
    Filed: November 10, 2006
    Publication date: May 31, 2007
    Applicant: ZENTARIS GmbH
    Inventors: Irene SEIPELT, Eckhard Claus, Eckhard Guenther, Tilmann Schuster, Michael Czech, Emmanuel Polymeropoulos
  • N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
    Patent number: 7211588
    Abstract: The invention relates to novel N-substituted indolyl-3-glyoxylamides of the general formula I, their preparation and use as medicaments, in particular for the treatment of tumors
    Type: Grant
    Filed: July 15, 2004
    Date of Patent: May 1, 2007
    Assignee: Zentaris GmbH
    Inventors: Matthias Gerlach, Tilmann Schuster, Peter Schmidt, Silke Baasner, Eckhard Günther
  • Indole derivatives having an apoptosis-inducing effect
    Patent number: 7205299
    Abstract: The invention relates to indole derivatives which are used as drugs for treating tumor diseases, in particular when there is drug resistance against other active compounds and where there is a metastasizing carcinoma.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: April 17, 2007
    Assignee: Zentaris GmbH
    Inventors: Matthias Gerlach, Tilmann Schuster, Peter Ernig, Peter Schmidt, Silke Baasner, Eckhard Günther
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 7056912
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: June 6, 2006
    Assignee: Zentaris GmbH
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 7026310
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: April 14, 2005
    Date of Patent: April 11, 2006
    Assignee: Zentaris GmbH
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs)
    Publication number: 20060014818
    Abstract: The present invention provides novel tetrahydrocarbazole derivatives which have improved properties and which can be employed as inhibitors of GPCRs. This results in the possibility of using the novel compounds to treat pathological conditions whose severity depends on the pathobiochemical effect of GPCRs. The compounds of the invention act in particular via an antagonistic inhibition of the LHRH receptor. The invention further provides medicaments which comprise one or more of the novel compounds as active ingredient. The medicaments are suitable in particular to be employed in an oral dosage form for a mammal, in particular a human.
    Type: Application
    Filed: June 30, 2005
    Publication date: January 19, 2006
    Inventors: Klaus Paulini, Matthias Gerlach, Eckhard Günther, Emmanuel Polymeropoulos, Silke Baasner, Peter Schmidt, Ronald Kühne, Arvid Soderhall
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 6936615
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: August 30, 2005
    Assignee: Zentaris GmbH
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 6890926
    Abstract: The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: May 10, 2005
    Assignee: Zentaris AG
    Inventors: Peter Emig, Eckhard Günther, Jürgen Schmidt, Bernd Nickel, Bernhard Kutscher
  • Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone
    Publication number: 20050004127
    Abstract: The invention relates to new quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone.
    Type: Application
    Filed: July 23, 2004
    Publication date: January 6, 2005
    Inventors: Peter Strehlke, Peter Droescher, Ulrich Buehmann, Norbert Schmees, Peter Muhn, Holger Hess-Stumpp, Roland Kuhne, Eckhard Guenther, Emmanuel Polymeropoulos, Antonius Ter Laak
  • Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone
    Patent number: 6790858
    Abstract: The present invention relates to a compound of formula (I): where R1-R6, W, X, and Y are defined herein, a composition includung the compound of formula (I), and a method for, e.g., male birth control, including administering an effective amount of a compound of formula (I) to a patient in need thereof.
    Type: Grant
    Filed: February 21, 2002
    Date of Patent: September 14, 2004
    Assignee: Zentaris AG
    Inventors: Peter Strehlke, Peter Droescher, Ulrich Buehmann, Norbert Schmees, Peter Muhn, Holger Hess-Stumpp, Roland Kühne, Eckhard Guenther, Emmanuel Polymeropoulos, Antonius M. Ter Laak
  • Heteroaryl derivatives and their use as medicaments
    Patent number: 6706722
    Abstract: The invention relates to novel acridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: March 16, 2004
    Assignee: Zentaris AG
    Inventors: Peter Emig, Eckhard Günther, Bernd Nickel, Gerhard Bacher, Silke Baasner, Thomas Beckers, Beate Aue
  • Heteroary1 derivatives and their use as medicaments
    Patent number: 6638935
    Abstract: The invention relates to novel pyridine derivatives of formula 1, to their preparation and to their use as medicaments, in particular for treating tumors
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: October 28, 2003
    Assignee: Zentaris AG
    Inventors: Peter Emig, Eckhard Günther, Bernhard Kutscher, Bernd Nickel, Jürgen Schmidt, Anita Storch
  • LHRH antagonists having improved solubility properties
    Patent number: 6627609
    Abstract: The invention relates to peptides which contain N-methylated amino acid units and have improved water solubility. Medicaments in which the peptides according to the invention are contained can be used for the treatment of hormone-dependent tumours and hormone-influenced non-malignant disorders.
    Type: Grant
    Filed: March 14, 2000
    Date of Patent: September 30, 2003
    Assignee: Zentaris AG
    Inventors: Michael Bernd, Bernhard Kutscher, Eckhard Günther, Peter Romeis, Thomas Reissmann, Thomas Beckers
  • Quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone
    Publication number: 20030105328
    Abstract: The invention relates to new quinoline, isoquinoline and phthalazine derivatives as antagonists of the gonadotropin-releasing hormone.
    Type: Application
    Filed: February 21, 2002
    Publication date: June 5, 2003
    Applicant: Schering AG
    Inventors: Peter Strehlke, Peter Droescher, Ulrich Buehmann, Norbert Schmees, Peter Muhn, Holger Hess-Stumpp, Ronald Kuhne, Eckhard Guenther, Emmanual Polymeropoulos, Antonius Ter Laak
  • Indolyl-3-glyoxylic acid derivatives having antitumor action
    Patent number: 6232327
    Abstract: The invention relates to the use of N-substituted indole-3-glyoxylamides of the general formula I as antitumor agents and to a pharmaceutical composition having antitumor action, characterized in that it contains at least one of the compounds of the general formula 1, if appropriate also in the form of the physiologically tolerable acid addition salts or N-oxides. Furthermore, the invention also includes antitumor agents comprising as active compound one or more N-substituted indole-3-glyoxylamides according to the general formula 1 and, if appropriate, their physiologically tolerable acid addition salts and, if possible, N-oxides and a pharmaceutically utilizable carrier and/or diluent or auxiliary substance in the form of tablets, coated tablets, capsules, solutions for infusion or ampoules, suppositories, patches, powder preparations which can be employed by inhalation, suspensions, creams and ointments.
    Type: Grant
    Filed: April 2, 1999
    Date of Patent: May 15, 2001
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Bernd Nickel, Istvan Szelenyi, Jürgen Schmidt, Peter Emig, Dietmar Reichert, Eckhard Günther, Kay Brune