Abstract: The invention provides a method of orally delivering a pharmaceutical composition to a test animal, and a method of evaluating for treatment or diagnosis of a medical condition, a pharmaceutical composition administered orally to a test animal, including administering to the test animal an effective amount of an oral thin film including the pharmaceutical composition, wherein orally delivering a pharmaceutical composition to the test animal is performed to evaluate the safety and efficacy of the pharmaceutical composition, and wherein reduced trauma is associated with administration of the pharmaceutical composition by oral thin film to the test animal, compared to a gavage administration. Further, a method of treatment of an alcohol uptake disorder (AUD) in a patient is provided, including administering to the patient afflicted therewith an effective amount of an oral thin film formulation of ivermectin.

Abstract: A thin film composition for oral administration that adheres to and dissolves in a mouth of a user, wherein the thin film is a single layered water-soluble solid comprising at least one D-amino acid contained in a plurality of hydrophobic carriers dispersed throughout the thin film. The hydrophobic carriers comprise oil and the composition further comprises a phospholipid, an emulsifier, and a water soluble polymer. The preferred D-amino acids are D-leucine, D-tryptophan, D-methionine, and D-tyrosine. A method of reducing dental plaque in a subject entails placing the thin film composition contemplated herein into a mouth of the subject.