Patents by Inventor Ed O'Connell

Ed O'Connell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
    Patent number: 8728525
    Abstract: The present disclosure relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical particles that are substantially amorphous or non-crystalline and are injectable through fine bore needles at high concentrations. The particles exhibit the pharmacokinetic and pharmacodynamnic properties of the active agent. The disclosure has special application for higher molecular weight proteins such as antibodies.
    Type: Grant
    Filed: November 7, 2006
    Date of Patent: May 20, 2014
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Larry R. Brown, Mark X. Yang, Ed O'Connell
  • Methods of processing compositions containing microparticles
    Patent number: 8367427
    Abstract: A method for processing multi-phasic dispersions is provided. The method comprises providing a multi-phasic dispersion including dispersed and continuous phases, providing one or more non-solvents comprising an aqueous solution containing at least one multivalent cation, exposing the multi-phasic dispersion to the non-solvent to form a suspension containing one or more liquid phases and the solid microparticles, and removing at least a portion of the resulting one or more liquid phases while retaining at least the microparticles, thereby removing at least a portion of the non-volatile material from the microparticles.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: February 5, 2013
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Ramin Darvari, Adam Lambert, Julia E. Rashba-Step, Mark X. Yang, Junhong Zhang, Ed O'Connell
  • Methods of processing compositions containing microparticles
    Patent number: 8323685
    Abstract: Methods for processing microparticles involve providing a composition comprising a plurality of solid microparticles and at least one non-volatile material, providing a non-solvent, and exposing the composition to the non-solvent to remove at least a portion of the non-volatile material from the composition while retaining at least the microparticles.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: December 4, 2012
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Uri Piran, Eugene Mehr, Larry R. Brown, John K. McGeehan, Ed O'Connell
  • METHODS OF PROCESSING COMPOSITIONS CONTAINING MICROPARTICLES
    Publication number: 20100047248
    Abstract: A method for processing multi-phasic dispersions is provided. The method comprises providing a multi-phasic dispersion including dispersed and continuous phases, providing one or more non-solvents comprising an aqueous solution containing at least one multivalent cation, exposing the multi-phasic dispersion to the non-solvent to form a suspension containing one or more liquid phases and the solid microparticles, and removing at least a portion of the resulting one or more liquid phases while retaining at least the microparticles, thereby removing at least a portion of the non-volatile material from the microparticles.
    Type: Application
    Filed: August 20, 2008
    Publication date: February 25, 2010
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.
    Inventors: Ramin Darvari, Adam Lambert, Julia E. Rashba-Step, Mark X. Yang, Junhong Zhang, Ed O'Connell
  • METHODS OF PROCESSING COMPOSITIONS CONTAINING MICROPARTICLES
    Publication number: 20100047903
    Abstract: Methods for processing microparticles involve providing a composition comprising a plurality of solid microparticles and at least one non-volatile material, providing a non-solvent, and exposing the composition to the non-solvent to remove at least a portion of the non-volatile material from the composition while retaining at least the microparticles.
    Type: Application
    Filed: August 20, 2008
    Publication date: February 25, 2010
    Applicants: BAXTER INTERNATIONAL INC., BAXTER HELTHCARE S.A.
    Inventors: Uri Piran, Eugene Mehr, Larry R. Brown, John K. McGeehan, Ed O'Connell
  • Protein Microspheres Retaining Pharmacokinetic and Pharmacodynamic Properties
    Publication number: 20070207210
    Abstract: The present disclosure relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical particles that are substantially amorphous or non-crystalline and are injectable through fine bore needles at high concentrations. The particles exhibit the pharmacokinetic and pharmacodynamnic properties of the active agent. The disclosure has special application for higher molecular weight proteins such as antibodies.
    Type: Application
    Filed: November 7, 2006
    Publication date: September 6, 2007
    Inventors: Larry Brown, Mark Yang, Ed O'Connell