Abstract: The performance of a mammal, manifested as a reduced oxygen uptake (VO2) during physical exercise, can be enhanced by administering to said mammal a non-toxic amount of nitrate and/or nitrite. Liquid, semi-solid and solid snack and food products and nutritional supplements, such as sport drinks are made available.

Abstract: Inorganic anions nitrate and nitrite influence metabolic rate and glucose homeostasis. Infusion of nitrite iv caused an acute drop in resting energy expenditure (oxygen consumption) and nitrate, when given perorally, caused a drop in oxygen consumption during exercise and a depression of the increase in blood glucose observed after an oral glucose tolerance test. The doses of nitrate and nitrite did not cause any detectable change in methemoglobin levels of blood. Also, nitrate and nitrite did not alter lactate levels in blood. This discovery provides useful treatments to regulate the energy expenditure and glucose homeostasis of a mammal by administration of inorganic nitrite and/or nitrate.

Abstract: The performance of a mammal, manifested as a reduced oxygen uptake (VO2) during physical exercise, can be enhanced by administering to said mammal a non-toxic amount of nitrate and/or nitrite. Liquid, semi-solid and solid snack and food products and nutritional supplements, such as sport drinks are made available.

Abstract: Levosimendan, or (?)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile, which has been mentioned for the treatment of congestive heart failure, is useful in the treatment of septic shock.

Abstract: The present invention discloses a device and a method for reducing the risk of hospital-acquired infections, nocosomial infections, originating from the insertion of the device and/or use of the device in the body of a human or animal. The invention in particular relates to a device releasing at least one low molecular antimicrobial compound permeating the device thereby exerting its antimicrobial effect also on the outside of the device.

Abstract: It has surprisingly been found that nasal NO release is greatly increased by the presence of a an oscillating airflow in healthy subjects. Accordingly, a device comprising means for generating and/or maintaining an oscillating airflow is described and suggested for use in the diagnosis of a condition of the upper airways of a human. The invention also encompasses method wherein the concentration and/or flow of at least one gaseous component in nasally exhaled air is determined and recorded in the presence and absence of an oscillating airflow acting on the upper airways or parts thereof.

Abstract: It has surprisingly been found that nasal NO release is greatly increased by the presence of a an oscillating airflow in healthy subjects. Accordingly, a device comprising means for generating and/or maintaining an oscillating airflow is described and suggested for use in the diagnosis of a condition of the upper airways of a human. The invention also encompasses method wherein the concentration and/or flow of at least one gaseous component in nasally exhaled air is determined and recorded in the presence and absence of an oscillating airflow acting on the upper airways or parts thereof.

Abstract: A gas sample containing an inorganic constituent, such as a sample of exhaled air is collected in a bag (b 1) comprising an inlet/outlet (2) and a reagent chamber (3) which makes possible the storage and transport of said sample and thus enables efficient and repeatable off-line determinations of inorganic components in said sample. A sample collection device, a system comprising said device and a method of its use is disclosed.

Abstract: Levosimendan, or (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile, which has been previously suggested for the treatment of congestive heart failure is useful in the treatment of septic shock.

Abstract: The present invention restores the normal low-dose flushing of the lower airways with air from the upper airways, containing nitric oxide (NO) and possible other biologically active agents by aspiration of air from the upper airways and introducing said air in the inspiratory airflow of a ventilator. The inventive apparatus and method is free from the risks associated with traditional administration of exogenous NO.

Abstract: Method for diagnosis of inflammatory conditions in the intestinal canal of humans, characterized in that NO is measured in the lumen of the intestines. The NO level obtained is then compared with the level obtained for healthy individuals or with the level obtained for the same individual at another occasion. An increased level compared to the normal levels in the intestines of the healthy population is an indication of an inflammatory condition in the intestine.

Abstract: Device and method for collecting endogenous gaseous nitric oxide (NO), in the urogenital tract, for example in the urinary tract and in the uterus and oviducts. According to one embodiment, a NO permeable, liquid impermeable inflatable body (16) is positioned in the urethra (5) surrounded by the prostate gland (17), whereby an additional inflatable body (4) positioned in the bladder (2) serves to seal off the bladder from the urethra and helps in the positioning of the device. The present invention further relates to a method and a system for use in the diagnosis of inflammatory states in said organs.

Abstract: Method for diagnosis of inflammatory conditions in the intestinal canal of humans, characterized in that NO is measured in the lumen of the intestines. The NO level obtained is then compared with the level obtained for healthy individuals or with the level obtained for the same individual at another occasion. An increased level compared to the normal levels in the intestines of the healthy population is an indication of an inflammatory condition in the intestine.

Abstract: The present invention restores the normal low-dose flushing of the lower airways with air from the upper airways, containing nitric oxide (NO) and possible other biologically active agents by aspiration of air from the upper airways and introducing said air in the inspiratory airflow of a ventilator. The inventive apparatus and method is free from the risks associated with traditional administration of exogenous NO.