Patents by Inventor EDDY ALFONSO

EDDY ALFONSO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial DNA gyrase inhibitors and methods of use thereof
    Patent number: 12714692
    Abstract: The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.
    Type: Grant
    Filed: April 26, 2023
    Date of Patent: August 25, 2026
    Assignees: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Fenfei Leng, Eddy Alfonso, Zifang Deng, Adel Nefzi, Kyle Rohde
  • Bacterial DNA gyrase inhibitors and methods of use thereof
    Patent number: 12558366
    Abstract: The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.
    Type: Grant
    Filed: October 21, 2024
    Date of Patent: February 24, 2026
    Assignee: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: Fenfei Leng, Eddy Alfonso, Zifang Deng
  • BACTERIAL DNA GYRASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20250090566
    Abstract: The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.
    Type: Application
    Filed: October 21, 2024
    Publication date: March 20, 2025
    Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: FENFEI LENG, EDDY ALFONSO, ZIFANG DENG
  • Bacterial DNA gyrase inhibitors and methods of use thereof
    Patent number: 12121528
    Abstract: The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.
    Type: Grant
    Filed: September 13, 2022
    Date of Patent: October 22, 2024
    Assignee: The Florida International University Board of Trustees
    Inventors: Fenfei Leng, Eddy Alfonso, Zifang Deng
  • BACTERIAL DNA GYRASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230364057
    Abstract: The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.
    Type: Application
    Filed: April 26, 2023
    Publication date: November 16, 2023
    Inventors: Fenfei LENG, Eddy ALFONSO, Zifang DENG, Adel NEFZI, Kyle ROHDE
  • BACTERIAL DNA GYRASE INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20230136466
    Abstract: The subject invention provides fluorophore-quencher nucleic acid molecules comprising relaxed or supercoiled DNA molecules, and their use in rapid and efficient high-throughput screening (HTS) assays to screen and identify compounds that inhibit DNA gyrases. These compounds can be used as antibiotics for treating bacterial infections, especially, multidrug resistant bacterial infections.
    Type: Application
    Filed: September 13, 2022
    Publication date: May 4, 2023
    Applicant: THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES
    Inventors: FENFEI LENG, EDDY ALFONSO, ZIFANG DENG