Patents by Inventor Eddy W. Yue

Eddy W. Yue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3- (2,4-dimethylthiazol-5-yl) indeno [1,2-c]pyrazol-4-one derivatives and their uses
    Publication number: 20020107274
    Abstract: The present invention relates to 3-(2,4-dimethylthiazol-5-yl)indeno[1,2-c]pyrazol-4-ones of formula 1
    Type: Application
    Filed: November 30, 2001
    Publication date: August 8, 2002
    Inventor: Eddy W. Yue
  • Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use
    Publication number: 20020103133
    Abstract: This invention is directed to antineoplastic agents conjugated to enzyme-cleavable peptides comprising the amino acid recognition sequence of a membrane-bound and/or cell-secreted peptidase, and to the use of such conjugated compounds as chemotherapeutic agents in the targeted treatment of cancers.
    Type: Application
    Filed: March 15, 2001
    Publication date: August 1, 2002
    Inventors: Robert A. Copeland, Charles F. Albright, Andrew P. Combs, Randine L. Dowling, Nilsa R. Graciani, Wei Han, C. A. Higley, Pearl S. Huang, Eddy W. Yue, Susan V. DiMeo
  • Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones
    Patent number: 6413957
    Abstract: The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
    Type: Grant
    Filed: August 15, 2000
    Date of Patent: July 2, 2002
    Assignee: Bristol-Myers Suibb Pharma Company
    Inventors: David A. Nugiel, David J. Carini, Susan V. Di Meo, Eddy W. Yue
  • Indeno [1,2-c] pyrazol-4-ones and their uses
    Patent number: 6407103
    Abstract: The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: June 18, 2002
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: David A. Nugiel, David J. Carini, Susan V. Di Meo, Eddy W. Yue
  • Indeno [1,2-c]pyrazol-4-ones and their uses
    Publication number: 20010027195
    Abstract: The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): 1
    Type: Application
    Filed: December 6, 2000
    Publication date: October 4, 2001
    Inventors: David A. Nugiel, David J. Carini, Susan V. DiMeo, Eddy W. Yue
  • Acylsemicarbazides and their uses
    Patent number: 6291504
    Abstract: The present invention relates to the synthesis of a new lass of indeno[1,2-c]pyrazol-4-ones of formula (I): that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: September 18, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: David A. Nugiel, David J. Carini, Susan V. Di Meo, Anup P. Vidwans, Eddy W. Yue