Abstract: An ultrasound information processing system comprises a plurality of ultrasound devices coupled to a high-speed serial ultrasound information bus, wherein each ultrasound device comprises a program for communicating with other ultrasound devices according to an ultrasound information exchange protocol (UIEP). The UIEP is a lightweight, connection-oriented protocol adapted to efficiently transfer ultrasound information among different devices on the ultrasound information bus. Each ultrasound device comprises an application layer program for performing an ultrasound function, as well as a lower protocol layer program for receiving and sending data across the ultrasound information bus according to a high-speed serial bus standard that provides both isochronous and asynchronous data delivery.