Patents by Inventor Edgar E. Ribi

Edgar E. Ribi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Refined detoxified endotoxin
    Patent number: 4866034
    Abstract: A method is provided for producing an effective adjuvant response or stimulating the immune response of a warm blooded animal which comprises administering to said warm blooded animal an effective amount of a composition comprising refined detoxified endotoxin in combination with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: May 8, 1985
    Date of Patent: September 12, 1989
    Assignee: Ribi Immunochem Research Inc.
    Inventor: Edgar E. Ribi
  • Method of inhibiting the onset of septicemia and endotoxemia
    Patent number: 4844894
    Abstract: The present invention is directed to a method of inhibiting to onset of septicemia and endotoxemia. The methods comprise administering to a warm-blooded animal an effective amount of a pharmaceutical composition comprising Monophosphoryl lipid A in combination with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: November 25, 1986
    Date of Patent: July 4, 1989
    Assignee: Ribi Immunochem Research Inc.
    Inventor: Edgar E. Ribi
  • Method of inhibiting the onset of acute radiation syndrome
    Patent number: 4629722
    Abstract: The present invention is directed to a method of inhibiting the onset of acute radiation syndrome caused by the exposure of warm-blooded animals to a whole body dose of at least about 100 rads of x-radiation. The invention is also directed to a method of inhibiting the onset of septicemia. The methods comprise administering to a warm-blooded animal an effective amount of a pharmaceutical composition comprising refined detoxified endotoxin in combination with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: July 12, 1984
    Date of Patent: December 16, 1986
    Assignee: Ribi ImmunoChem Research, Inc.
    Inventor: Edgar E. Ribi
  • Purification of trehalose dimycolates
    Patent number: 4579945
    Abstract: A method of purifying crude trehalose dimycolates (TDM) is disclosed which comprises dissolving crude TDM in a solvent and then subjecting said solution to a low pressure silica gel column operating at a pressure between about 10 and 300 psi wherein the silica gel comprises particles in the range of between about 15 and 63 microns. The product of this process is also disclosed.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: April 1, 1986
    Assignee: Ribi ImmunoChem Research, Inc.
    Inventors: Steven M. Schwartzman, Edgar E. Ribi
  • Stable composition and preparation thereof
    Patent number: 4520019
    Abstract: A stable composition containing cell wall skeleton (CWS) and trehalose dimycolates (TDM) which may be effectively reconstituted after lyophilization. The composition is useful in the treatment of various cancerous tumors in animals without side effects. Also disclosed is a method of producing the composition and a method of treating cancerous tumors in animals using said composition.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: May 28, 1985
    Assignee: Ribi ImmunoChem Research, Inc.
    Inventors: Edgar E. Ribi, John L. Cantrell, Steven M. Schwartzman
  • Refined detoxified endotoxin product
    Patent number: 4505899
    Abstract: A pharmaceutical composition comprising refined detoxified endotoxin, trehalose dimycolate, and an acetone precipitated by-product of endotoxic glycolipids extracted with chloroform-methanol (ACP) is disclosed which is useful for the treatment of cancerous tumors. Methods of using the composition for these purposes are also disclosed.
    Type: Grant
    Filed: March 6, 1984
    Date of Patent: March 19, 1985
    Assignee: Ribi ImmunoChem Research, Inc.
    Inventors: Edgar E. Ribi, John L. Cantrell
  • Refined detoxified endotoxin product
    Patent number: 4505900
    Abstract: A pharmaceutical composition comprising refined detoxified endotoxin, cell wall skeleton and trehalose dimycolate is disclosed which is effective for the treatment of cancerous tumors. Methods of using the composition for these purposes are also disclosed.
    Type: Grant
    Filed: March 8, 1984
    Date of Patent: March 19, 1985
    Assignee: Ribi ImmunoChem Research, Inc.
    Inventors: Edgar E. Ribi, Steven M. Schwartzman, John L. Cantrell
  • Refined detoxified endotoxin product
    Patent number: 4436728
    Abstract: A pharmaceutical composition comprising refined detoxified endotoxin, cell wall skeleton and trehalose dimycolate is disclosed which is effective for the treatment of cancerous tumors. Methods of using the composition for these purposes are also disclosed.
    Type: Grant
    Filed: May 26, 1982
    Date of Patent: March 13, 1984
    Assignee: Ribi ImmunoChem Research, Inc.
    Inventors: Edgar E. Ribi, Steven M. Schwartzman, John L. Cantrell
  • Refined detoxified endotoxin product
    Patent number: 4436727
    Abstract: A refined detoxified endotoxin (RDE) product is disclosed which, when combined with cell wall skeleton (CWS), results in a composition useful for the treatment of cancerous tumors. Methods of making RDE as well as methods of using the combination of RDE and CWS are also disclosed.
    Type: Grant
    Filed: May 26, 1982
    Date of Patent: March 13, 1984
    Assignee: Ribi ImmunoChem Research, Inc.
    Inventor: Edgar E. Ribi
  • Refined detoxified endotoxin product
    Patent number: 4435386
    Abstract: A pharmaceutical composition comprising refined detoxified endotoxin, trehalose dimycolate, and an acetone precipitated by-product of endotoxic glycolipids extracted with chloroform-methanol (ACP) is disclosed which is useful for the treatment of cancerous tumors. Methods of using the composition for these purposes are also disclosed.
    Type: Grant
    Filed: May 26, 1982
    Date of Patent: March 6, 1984
    Assignee: Ribi ImmunoChem Research, Inc.
    Inventors: Edgar E. Ribi, Cantrell John L.