Patents by Inventor Edgar Fritschi

Edgar Fritschi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5284872
    Abstract: New organic nitrate compounds, formed by condensing a nitrato alkanoic acid with a sulfur-containing amino acid or peptide followed by the reaction of the resulting product with an amino acid, N-acylamino acid, peptide or an N-acyl peptide to produce a thio ester thereof, which prevent nitrate tolerance or overcome existing tolerance and which are useful for the treatment of cardiac diseases including circulatory diseases, coronary dilation, high blood pressure, cardiac insufficiency and for dilating the peripheral vessels.
    Type: Grant
    Filed: April 5, 1991
    Date of Patent: February 8, 1994
    Assignee: Schwarz Pharma AG
    Inventors: Klaus Sandrock, Eike Noack, Edgar Fritschi, Ralf Kanzler, Martin Feelisch
  • Patent number: 4933368
    Abstract: N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling refractory tumors in mammals are described.
    Type: Grant
    Filed: May 31, 1989
    Date of Patent: June 12, 1990
    Assignee: Godecke Aktiengesellschaft
    Inventors: Gerhard Satzinger, Manfred Herrmann, Edgar Fritschi, Ute Weiershausen
  • Patent number: 4857662
    Abstract: N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling malignant, proliferative and auto-immune diseases and for immunosuppressive therapy upon grafting are described.
    Type: Grant
    Filed: February 9, 1984
    Date of Patent: August 15, 1989
    Assignee: Godecke Aktiengesellschaft
    Inventors: Gerhard Satzinger, Manfred Hermann, Edgar Fritschi, Ute Weiershausen
  • Patent number: 4816485
    Abstract: N-phenylbenzamide derivatives of the general formula I ##STR1## wherein the radicals R.sup.1, R.sup.2, and R.sup.3, which can be the same or different, are a hydrogen atom or a methyl radical, as well as the pharmacologically acceptable salts thereof for controlling malignant, proliferative and auto-immune diseases and for immunosuppressive therapy upon grafting are described.
    Type: Grant
    Filed: March 30, 1987
    Date of Patent: March 28, 1989
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Manfred Herrmann, Edgar Fritschi, Ute Weiershausen
  • Patent number: 4762837
    Abstract: 4-Alkoxy-pyrido[2,3-d]pyrimidine derivatives are described as well as processes for their preparation.For reason of their vasospasmolytic effects these compounds are mainly indicated for the treatment of cerebral, cardiac, and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arterioschlerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality.
    Type: Grant
    Filed: May 29, 1987
    Date of Patent: August 9, 1988
    Assignee: Godecke Aktiengesellschaft
    Inventors: Jurgen Kleinschroth, Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
  • Patent number: 4760081
    Abstract: The present invention describes 1,6-naphthyridine derivatives of the general formula: ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromatic or heteroaromatic ring, R.sup.2 is a straight-chained or branched alkyl radical containing up to four carbon atoms or a benzyl radical, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radicals or an alkoxycarbonyl radical containing up to four carbon atoms, R.sup.4 is a straight-chained or branched alkyl radical containing up to four carbons and R.sup.5 is a carboxyl group or a straight-chained, branched or cyclic alkoxycarbonyl radical which contains up to 17 carbon atoms and optionally also contains an oxygen, sulphur or nitrogen atom; as well as the pharmacologically acceptable salts thereof, which are useful for treating diseases of the blood vessels.
    Type: Grant
    Filed: January 28, 1987
    Date of Patent: July 26, 1988
    Assignee: Goedecke Aktiengesellschaft
    Inventors: Gerhard Satzinger, Johannes Hartenstein, Karl Mannhardt, Jurgen Kleinschroth, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
  • Patent number: 4711901
    Abstract: The present invention describes 1,6-naphthyridine derivatives of the general formula: ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromtic or heteroaromatic ring, R.sup.2 is a straight-chained or branched alkyl radical containing up to four carbon atoms or a benzyl radical, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radical or an alkoxycarbonyl radical containing up to four carbon atoms, R.sup.4 is a straight-chained or branched alkyl radical containing up to four carbons and R.sup.5 is a carbonyl group or a straight-chained, branched or cyclic alkoxycarbonyl radical which contains up to 17 carbon atoms and optionally also contains an oxygen, sulphur or nitrogen atom; as well as the pharamacologically acceptable salts thereof, which are useful for treating diseases of the blood vessels.
    Type: Grant
    Filed: July 30, 1986
    Date of Patent: December 8, 1987
    Inventors: Gerhard Satzinger, Johannes Hartenstein, Karl Mannhardt, Jurgen Kleinschroth, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
  • Patent number: 4698341
    Abstract: New 1,6-naphthyridinone derivatives of the formula I ##STR1## are herein described wherein R.sup.1 represents an unsubstituted or substituted aromatic or heteroaromatic ring;R.sup.2 is hydrogen, a straight-chained or branched alkyl, alkoxyalkyl, or a substituted or unsubstituted aminoalkyl group with up to ten carbon atoms;R.sup.3 is hydrogen, a straight-chained or branched alkyl group, or an alkoxycarbonyl radical with up to four carbon atoms;R.sup.4 is hydrogen, or a morpholinoethyl group;R.sup.5 is a straight-chained or branched alkyl group with up to four carbon atoms, or an amino group; andR.sup.6 is a carboxyl group, or an alkyl- or alkyloxyalkyl carbonyl radical, containing up to 12 carbon atoms and optionally interrupted by an oxygen, sulphur, or nitrogen atom;as well as optionally the pharmacologically acceptable salts thereof; processes for the preparation of these derivatives and their use in the control of vascular diseases.
    Type: Grant
    Filed: July 11, 1985
    Date of Patent: October 6, 1987
    Assignee: Godecke Aktiengesellschaft
    Inventors: Gerhard Satzinger, Johannes Hartenstein, Karl Mannhardt, Jurgen Kleinschroth, Manfred Herrmann, Edgar Fritschi, Horst-Dietmar Tauschel, Bernd Wagner, Gunter Wolf
  • Patent number: 4681882
    Abstract: 4-Alkoxy-pyrido[2,3-d]pyrimidine derivatives are described as well as processes for their preparation.For reason of their vasospasmolytic effects these compounds are mainly indicated for the treatment of cerebral, cardiac, and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arteriosclerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality.
    Type: Grant
    Filed: October 16, 1985
    Date of Patent: July 21, 1987
    Assignee: Godecke Aktiengesellschaft
    Inventors: Jorgen Kleinschroth, Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Gonter Weinheimer, Edgar Fritschi
  • Patent number: 4677108
    Abstract: 4-Oxo-pyrido[2,3-d]pyrimidine derivatives are herein described as well as processes for their preparation.These compounds possess valuable pharmacological properties. As calcium antagonists they exert vasospasmolytic, vasodilatory, and antihypertensive activities. Surprisingly some of the compounds also have the effect of increasing contractility. They are therefore particularly suited for the treatment of vascular diseases.
    Type: Grant
    Filed: October 16, 1985
    Date of Patent: June 30, 1987
    Assignee: Warner-Lambert Company
    Inventors: Jurgen Kleinschroth, Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
  • Patent number: 4626546
    Abstract: The invention is concerned with partially new compounds of the general formula ##STR1## wherein R.sup.1 is a hydrogen atom or an alkyl group with up to four carbon atoms and R.sup.2 a substituted phenyl radical and the pharmacologically acceptable salts thereof.The compounds can be prepared according to known procedures and show surprisingly a cardiovascular efficacy. They are capable of decompensating cardiac insufficiencies to a large extent. In addition to the new compounds, claim is also made for pharmaceutical compositions which contain compounds according to the general formula and their application for controlling cardiac and vascular diseases.
    Type: Grant
    Filed: August 3, 1984
    Date of Patent: December 2, 1986
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Manfred Herrmann, Edgar Fritschi, Wolfgang Steinbrecher
  • Patent number: 4612311
    Abstract: 1,2,4-Benzothiadiazine oxide derivatives of the general Formula I ##STR1## in which R.sup.1 represents an unsubstituted or substituted aryl radical;R.sup.2 and R.sup.5, which may be the same or different, and represent hydrogen, halogen, or a nitro group, andR.sup.3 represents a hydrogen atom or a hydroxy radical, an alkyl, alkoxy alkyl or alkoxy carbonyl radical with up to four carbon atoms, unsubstituted or substituted by halogen, hydroxy, amino, alkyl amino or dialkyl amino radicals, or a phenyl radical, unsubstituted or substituted by halogen,are described as having anxiolytic effects on the central nervous system.
    Type: Grant
    Filed: September 4, 1985
    Date of Patent: September 16, 1986
    Assignee: Warner-Lambert Company
    Inventors: Hubert Barth, Johannes Hartenstein, Gerhard Satzinger, Edgar Fritschi, Hartmut Osswald, Gerd Bartoszyk
  • Patent number: 4605673
    Abstract: The invention is concerned with 7H-dibenzo(a,c)-cyclohepten-5-one-(7) derivatives of general formula I ##STR1## wherein R.sup.1 and R.sup.2 can be the same or different, a hydrogen atom, an alkyl radical containing 1 to 3 carbon atoms, or, together with the nitrogen atom to which they are attached form a heterocyclic ring containing 3 to 6 carbon atoms,n is 2 or 3R.sup.3 is a hydrogen atom or a halogen atom andX is either a methylene radical or an oxygen atomand the pharmacologically acceptable salts thereof with inorganic and organic acids.The invention is furthermore concerned with analogous processes for the preparation thereof and their application for controlling psychic diseases and gastric and/or intestinal ulcers.
    Type: Grant
    Filed: December 19, 1983
    Date of Patent: August 12, 1986
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Edgar Fritschi, Manfred Herrmann
  • Patent number: 4605552
    Abstract: Pharmaceutical compositions for administration by inhalation, wherein calcium-antagonists are employed as the active substances, e.g., metered-sprays of calcium-antagonists, in particular of diltiazem and a process for their manufacture are described.
    Type: Grant
    Filed: July 16, 1984
    Date of Patent: August 12, 1986
    Assignee: Warner-Lambert Company
    Inventor: Edgar Fritschi
  • Patent number: 4598076
    Abstract: The present invention provides compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, are unsubstituted or substituted aromatic rings, Alk is a straight-chained or branched lower hydrocarbon chain and Z is a hydrogen atom, with the proviso that when Alk is a straight-chained hydrocarbon chain, Z can also be a lower alkylamino radical of the general formula II ##STR2## in which R.sup.3 and R.sup.4 are the same or different and are hydrogen atoms or straight-chained or branched lower alkyl radicals or R.sup.3 and R.sup.4, together with the nitrogen atom to which they are attached, can also form a ring optionally containing further hetero atoms; and the pharmacologically acceptable salts thereof.The present invention also provides an inventive process for preparing these compounds, as well as pharmaceutical compositions containing them. The compounds I may be used in the therapy of inflammations and they are free of gastrointestinal side effects.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: July 1, 1986
    Assignee: Warner-Lambert Company
    Inventors: Hubert Barth, Edgar Fritschi, Volker Ganser, Johannes Hartenstein, Manfred Herrmann, Gerhard Satzinger
  • Patent number: 4587263
    Abstract: New aminosulfonic acids of the general formula I ##STR1## wherein n represents the figures 4, 5, or 6, prepared according to previously known processes and characterized by very good tolerance and valuable cardiovascular properties, serve for the therapy of dysrhythmia and are superior to procaine.
    Type: Grant
    Filed: July 26, 1984
    Date of Patent: May 6, 1986
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Johannes Hartenstein, Edgar Fritschi, Wolf-Dieter Vigelius
  • Patent number: 4584374
    Abstract: 4-Thioxobenzopyrano[2,3-d]-pyrimidine derivatives of the general formulae Ia or Ib ##STR1## are described. Compounds Ia and Ib are tautomers and are valuable intermediates for the preparation of 5H-[1]-benzopyrano[2,3-d]pyrimidine derivatives having ulcer-protective action without inhibition of secretion.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: April 22, 1986
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Hubert Barth, Johannes Hartenstein, Manfred Herrmann, Edgar Fritschi, Ilse-Dore Schutt
  • Patent number: 4578380
    Abstract: The invention relates to 5H-[1]benzopyrano-[2,3-d]pyrimidine derivatives of the general formula I ##STR1## which may be prepared by means of a new chemical process and have a protective effect similar to that of cimetidine, but do not exhibit the undesired side effects of antisecretory agents. The invention is based on a new mucoprotective mode of action which prevents lesions of the mucous membrane epithelium to arise.
    Type: Grant
    Filed: September 24, 1984
    Date of Patent: March 25, 1986
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Hubert Barth, Johannes Hartenstein, Manfred Herrmann, Edgar Fritschi, Ilse-Dore Schutt
  • Patent number: 4563471
    Abstract: 4-Oxothiazolidin-2-ylidene-acetamide derivatives, processes for their preparation, pharmaceutical compositions and a method for treating diseases of the central nervous system such as epilepsy are described.
    Type: Grant
    Filed: May 8, 1984
    Date of Patent: January 7, 1986
    Assignee: Warner-Lambert Company
    Inventors: Gerhard Satzinger, Manfred Herrmann, Edgar Fritschi, Johannes Hartenstein, Gerd Bartoszyk
  • Patent number: 4517185
    Abstract: The present invention provides compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, are unsubstituted or substituted aromatic rings, Alk is a straight-chained or branched lower hydrocarbon chain and Z is a hydrogen atom, with the proviso that when Alk is a straight-chained hydrocarbon chain, Z can also be a lower alkylamino radical of the general formula II ##STR2## in which R.sup.3 and R.sup.4 are the same or different and are hydrogen atoms or straight-chained or branched lower alkyl radicals or R.sup.3 and R.sup.4, together with the nitrogen atom to which they are attached, can also form a ring optionally containing further hetero atoms; and the pharmacologically acceptable salts thereof.The present invention also provides an inventive process for preparing these compounds, as well as pharmaceutical compositions containing them. The compounds I may be used in the therapy of inflammations and they are free of gastrointestinal side effects.
    Type: Grant
    Filed: March 25, 1983
    Date of Patent: May 14, 1985
    Assignee: Warner-Lambert Company
    Inventors: Hubert Barth, Edgar Fritschi, Volker Ganser, Johannes Hartenstein, Manfred Herrmann, Gerhard Satzinger