Patents by Inventor Edgar Leibold

Edgar Leibold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10393762
    Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: August 27, 2019
    Assignees: METANOMICS GMBH, Ruprecht-Karls-Universitaet Heidelberg
    Inventors: Jens Fuhrmann, Regina Reszka, Juergen Kastler, Kristina Busch, Edgar Leibold, Hugo Katus, Norbert Frey, Johanna Sigl, Tanja Weis
  • Publication number: 20160169863
    Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
    Type: Application
    Filed: February 25, 2016
    Publication date: June 16, 2016
    Applicant: BASF SE
    Inventors: Bennard van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strasse, Tilmann Walk, Ralf Looser, Edgar Leibold, Hennicke Kamp, Georgia Coelho Palermo Cunha, Michael Herold, Jan C Wiemer, Alexander Prokudin
  • Publication number: 20160154012
    Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
    Type: Application
    Filed: February 1, 2016
    Publication date: June 2, 2016
    Applicants: Metanomics GmbH, Rupreht-Karls-Universität Heidelberg
    Inventors: Jens Fuhrmann, Regina Reszka, Jürgen Kastler, Kristina Busch, Edgar Leibold, Hugo A. Katus, Norbert Frey, Johanna Wolf, Tanja Weis
  • Patent number: 9304136
    Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection including characteristic values of at least five metabolites, a data storage medium including data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: April 5, 2016
    Assignee: BASF SE
    Inventors: Bennard van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Tilmann B. Walk, Ralf Looser, Edgar Leibold, Hennicke Kamp, Georgia Coelho Palermo Cunha, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine
  • Patent number: 9285378
    Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: March 15, 2016
    Assignees: Metanomics GmbH, Rupreht-Karls-Universität Heidelberg
    Inventors: Jens Fuhrmann, Regina Reszka, Jürgen Kastler, Kristina Busch, Edgar Leibold, Hugo Katus, Norbert Frey, Johanna Wolf, Tanja Weis
  • Patent number: 8808979
    Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction.
    Type: Grant
    Filed: May 25, 2009
    Date of Patent: August 19, 2014
    Assignee: BASF SE
    Inventors: Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Eric Fabian, Volker Strauss, Hennicke Kamp, Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold
  • Publication number: 20140186964
    Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
    Type: Application
    Filed: January 10, 2014
    Publication date: July 3, 2014
    Applicant: BASF SE
    Inventors: Bennard van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Tilmann B. Walk, Ralf Looser, Edgar Leibold, Hennicke Kamp, Georgia Coelho Palermo Cunha, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine
  • Patent number: 8658427
    Abstract: The present invention pertains to the field of toxicological assessments of risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing increased peroxisomal proliferation. It also relates to a method of determining whether a compound is capable of inducing such peroxisomal proliferation in a subject and to a method of identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection of characteristic values of at least five metabolites, a data storage medium for the data collection, and a system and a device for diagnosing increased peroxisomal proliferation. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing increased peroxisomal proliferation in a subject.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: February 25, 2014
    Assignee: BASF SE
    Inventors: Bennard van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Tilmann B. Walk, Ralf Looser, Edgar Leibold, Hennicke Kamp, Georgia Coelho Palermo Cunha, Michael Manfred Herold, Jan C Wiemer, Alexandre Prokoudine
  • Patent number: 8597875
    Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: December 3, 2013
    Assignee: BASF SE
    Inventors: Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Eric Fabian, Volker Strauss, Hennicke Kamp, Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C Wiemer, Alexandre Prokoudine, Edgar Leibold
  • Patent number: 8563253
    Abstract: The present invention relates to a method for diagnosing hemolytic anemia or a predisposition thereof. It also relates to a method of determining whether a compound is capable of inducing hemolytic anemia in a subject and to a method of identifying a drug for treating hemolytic anemia. Furthermore, the present invention relates to a data collection comprising characteristic values of metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing hemolytic anemia. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing hemolytic anemia in a subject.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: October 22, 2013
    Assignee: Metanomics GmbH
    Inventors: Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold, Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Eric Fabian, Volker Strauss
  • Publication number: 20120286157
    Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject, a method for identifying whether a subject is in need for a therapy of heart failure or a method for determining whether a heart failure therapy is successful. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
    Type: Application
    Filed: January 28, 2011
    Publication date: November 15, 2012
    Applicants: Rupreht-Karls-Universitat Heidelberg, Metanomics GmbH
    Inventors: Jens Fuhrmann, Regina Reszka, Jürgen Kastler, Kristina Busch, Edgar Leibold, Hugo Katus, Norbert Frey, Johanna Wolf, Tanja Weis
  • Patent number: 8216847
    Abstract: The present invention relates to a method for diagnosing a predisposition for diabetes, comprising determining a metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing the metabolite to a reference to diagnose the, predisposition for diabetes. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising the data collection. The present invention also relates to a system comprising methods or devices for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Additionally, diagnostic methods or devices comprising a metabolite and its use for manufacture of the diagnostic method or device for diagnosing a predisposition for diabetes are provided, along with a method for identifying diabetes-related metabolites.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: July 10, 2012
    Assignee: Metanomics GmbH
    Inventors: Bianca Bethan, Kristina Busch, Jan C Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
  • Patent number: 8216848
    Abstract: The present invention relates to a method for diagnosing diabetes or a predisposition thereof, comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing the metabolite to a reference to diagnose diabetes or a predisposition therefor. The present invention further encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising the data collection. The present invention also relates to a system comprising methods or devices for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. The present invention also encompasses diagnostic methods or devices comprising at least one metabolite and use of the metabolite for the manufacture of diagnostic methods and devices for diagnosing diabetes; and a method for identifying diabetes-related metabolites.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: July 10, 2012
    Assignee: Metanomics GmbH
    Inventors: Bianca Bethan, Kristina Busch, Jan C Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
  • Publication number: 20120132797
    Abstract: The present invention relates to a method for diagnosing thyroid disorders. It also relates to a method of determining whether a compound is capable of inducing a thyroid disorder in a subject and to a method of identifying a drug for treating a thyroid disorder. Furthermore, the present invention relates a device for diagnosing a thyroid disorder and diagnostic uses.
    Type: Application
    Filed: July 13, 2010
    Publication date: May 31, 2012
    Applicant: BASF SE
    Inventors: Volker Strauss, Hennicke Kamp, Eric Fabian, Georgia Coelho Palermo Cunha, Werner Mellert, Bennard van Ravenzwaay, Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Weimer, Alexandre Prokoudine, Edgar Leibold
  • Publication number: 20120122243
    Abstract: The present invention relates to a method, preferably an ex vivo method, for diagnosing prostate carcinomas and/or predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from prostate carcinomas or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby prostate carcinomas or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium.
    Type: Application
    Filed: June 2, 2010
    Publication date: May 17, 2012
    Applicants: CHARITE UNIVERSITATSMEDIZIN BERLIN, METANOMICS HEALTH GMBH
    Inventors: Beate Kamlage, Bianca Bethan, Regina Reszka, Edgar Leibold, Klaus Jung, Michael Lein, Glen Kristiansen
  • Publication number: 20110163226
    Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing liver toxicity. It also relates to a method of determining whether a compound is capable of inducing such liver toxicity in a subject and to a method of identifying a drug for treating liver toxicity. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosing liver toxicity. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of a diagnostic device or composition for diagnosing liver toxicity in a subject. For each sex, a different metabolome pattern, i.e. a different set of analytes is disclosed.
    Type: Application
    Filed: May 26, 2009
    Publication date: July 7, 2011
    Applicant: BASF SE
    Inventors: Bennard van Ravenzwaay, Werner Mellert, Georgia Coelho Palermo Cunha, Eric Fabian, Volker Strauss, Hennicke Kamp, Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold
  • Publication number: 20110129933
    Abstract: The present invention pertains to the field of toxicological as for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating increased peroxisomal proliferation. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five metabolites, a data storage medium comprising said data collection, and a system and a device for diagnosis. Finally, the present invention pertains to the use of a group of metabolites or means for the determination thereof for the manufacture of diagnostic devices or compositions.
    Type: Application
    Filed: May 26, 2009
    Publication date: June 2, 2011
    Applicant: BASF SE
    Inventors: Bennard Van Ravenzwaay, Werner Mellert, Eric Fabian, Volker Strauss, Tilmann B. Walk, Ralf Looser, Edgar Leibold, Hennicke Kamp, Georgia Coelho Palermo Cunha, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine
  • Publication number: 20110091929
    Abstract: The present invention pertains to the field of toxicological assessments for risk stratification of chemical compounds. Specifically, it relates to a method for diagnosing the pro-pathological effect of compounds which are inducing liver enzymes. It also relates to a method of determining whether a compound is capable of exhibiting pro-pathological effects on the liver by enzyme induction in a subject and to a method of identifying a drug for treating the pro-pathological effect of liver enzyme induction. Furthermore, the present invention relates to a data collection comprising characteristic values of at least five analytes, a data storage medium comprising said data collection, and a system and a device for diagnosing the pro-pathological effect of liver enzyme induction.
    Type: Application
    Filed: May 25, 2009
    Publication date: April 21, 2011
    Applicant: BASF SE
    Inventors: Bennard van Ravenzwaay, Werner Mellert, Georgia CoelhoPalermo Cunha, Eric Fabian, Volker Strauss, Hennicke Kamp, Tilmann B. Walk, Ralf Looser, Michael Manfred Herold, Jan C. Wiemer, Alexandre Prokoudine, Edgar Leibold
  • Publication number: 20100236321
    Abstract: The present invention relates to a method for diagnosing a predisposition for diabetes comprising determining at least one metabolite in a test sample of a subject suspected to have a predisposition for diabetes and comparing said at least one metabolite to a reference, whereby a predisposition for diabetes is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing a predisposition for diabetes.
    Type: Application
    Filed: March 21, 2007
    Publication date: September 23, 2010
    Applicant: Metanomics GmbH
    Inventors: Bianca Bethan, Kristina Busch, Jan Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer
  • Publication number: 20100163720
    Abstract: The present invention relates to a method for diagnosing diabetes or a predisposition thereof comprising determining at least one metabolite in a test sample of a subject suspected to suffer from diabetes or to have a predisposition therefor and comparing said at least one metabolite to a reference, whereby diabetes or a predisposition therefor is to be diagnosed. Moreover, the present invention encompasses a collection of metabolites, a data collection comprising characteristic values of metabolites and a storage medium comprising said data collection. Furthermore, the present invention also relates to a system comprising means for comparing characteristic values of metabolites of a sample operatively linked to a data storage medium. Further encompassed by the present invention are diagnostic means comprising at least one metabolite and the use of said at least one metabolite for the manufacture of diagnostic means for diagnosing diabetes.
    Type: Application
    Filed: March 21, 2007
    Publication date: July 1, 2010
    Applicant: Metanomics GmbH
    Inventors: Bianca Bethan, Kristina Busch, Jan Wiemer, Martijn Gipmans, Edgar Leibold, Jochen Spranger, Thomas Bobbert, Andreas Friedrich Hermann Pfeiffer