Patents by Inventor Edgar O. Ong

Edgar O. Ong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acids encoding endotheliases, endotheliases and uses thereof
    Patent number: 7276364
    Abstract: Provided herein are endotheliases and portions, particularly, the protease domains, and nucleic acids that encode the endotheliases. The endotheliases are transmembrane proteases expressed in endothelial cells. The nucleic acids and encoded proteins and protease domain portions thereof are used in a variety of prognostic, diagnostic, therapeutic and screening methods, including methods for screening for compounds that modulate angiogenesis.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: October 2, 2007
    Assignee: Dendreon Corporation
    Inventors: Edwin L. Madison, Edgar O. Ong
  • Inhibitors of serine protease activity of matriptase or MTSP1
    Patent number: 7157596
    Abstract: The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of using the compounds and pharmaceutical compositions to treat conditions ameliorated by inhibition of matriptase or MTSP1.
    Type: Grant
    Filed: March 5, 2002
    Date of Patent: January 2, 2007
    Inventors: Joseph E. Semple, Gary S. Coombs, John E. Reiner, Edgar O Ong, Gian Luca Araldi
  • Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
    Patent number: 7125703
    Abstract: Provided herein are type II transmembrane serine protease 7 (MTSP7) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP7 are provided.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: October 24, 2006
    Assignee: Dendreon Corporation
    Inventors: Edwin L. Madison, Edgar O. Ong
  • Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
    Patent number: 7105333
    Abstract: Provided herein are type II transmembrane serine protease 9 (MTSP9) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP9 are provided.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: September 12, 2006
    Assignee: Deadreon Corporation
    Inventors: Edwin L. Madison, Edgar O. Ong
  • Inhibitors of serine protease activity of matriptase or MTSP1
    Patent number: 6797504
    Abstract: The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of using the compounds and pharmaceutical compositions to treat conditions ameliorated by inhibition of matriptase or MTSP1. The invention provides recombinant serine protease domains and methods of using peptides comprising a recombinant serine protease domain to screen for compounds that inhibit serine protease activity of matriptase or MTSP1.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: September 28, 2004
    Assignee: Dendreon San Diego LLC
    Inventors: Edwin L. Madison, Joseph Edward Semple, Gary Samuel Coombs, John Eugene Reiner, Edgar O. Ong, Gian Luca Araldi
  • Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
    Publication number: 20030166851
    Abstract: Provided herein are type II transmembrane serine protease 9 (MTSP9) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP9 are provided.
    Type: Application
    Filed: March 27, 2002
    Publication date: September 4, 2003
    Applicant: Corvas international, Inc.
    Inventors: Edwin Madison, Edgar O. Ong
  • Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon
    Publication number: 20030134794
    Abstract: Provided herein are polypeptides designated CVSP17 polypeptides that exhibit protease activity as a single chain or as an activated two chain form. Methods using the polypeptides to identify compounds that modulate the protease activity thereof are provided. The polypeptides also serve as tumor markers.
    Type: Application
    Filed: November 20, 2002
    Publication date: July 17, 2003
    Inventors: Edwin L. Madison, Edgar O. Ong
  • Nucleic acid molecules encoding a transmembrane serine protease 20, the encoded polypeptides and methods based thereon
    Publication number: 20030134298
    Abstract: Provided herein are type II transmembrane serine protease 20 (MTSP20) polypeptides. Zymogen and activated forms of these polypeptides as well as single and multi-chain forms of the polypeptides and protease domains are also provided. Methods using the polypeptides for screening, diagnosis and prognosis are also provided.
    Type: Application
    Filed: July 3, 2002
    Publication date: July 17, 2003
    Inventors: Edwin L. Madison, Edgar O. Ong
  • Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
    Publication number: 20030119168
    Abstract: Provided herein is are polypeptides that include the protease domain of a type II transmembrane serine protease (MTSP) as a single chain. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP are provided. Also provided are MTSPs designated MTSP3 and MTSP4 and a form of an MTSP designated MTSP6.
    Type: Application
    Filed: February 2, 2001
    Publication date: June 26, 2003
    Applicant: Corvas International, Inc.
    Inventors: Edwin L. Madison, Edgar O. Ong, Jiunn-Chern Yeh
  • Inhibitors of serine protease activity of matriptase or MTSP1
    Publication number: 20030050251
    Abstract: The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of using the compounds and pharmaceutical compositions to treat conditions ameliorated by inhibition of matriptase or MTSP1.
    Type: Application
    Filed: March 5, 2002
    Publication date: March 13, 2003
    Inventors: Joseph E. Semple, Gary S. Coombs, John E. Reiner, Edgar O. Ong, Gian Luca Araldi
  • Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
    Publication number: 20030008372
    Abstract: Provided herein are type II transmembrane serine protease 7 (MTSP7) polypeptides. Zymogen and activated forms of these polypeptides as well as single and two chain forms of the protease domain are also provided. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP7 are provided.
    Type: Application
    Filed: March 13, 2002
    Publication date: January 9, 2003
    Applicant: Corvas International, Inc.
    Inventors: Edwin L. Madison, Edgar O. Ong