Patents by Inventor Edgar R. Civitello
Edgar R. Civitello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6093383Abstract: This invention relates to bisamine bisthiol radiolabel binding moieties and synthetic methods therefor. Specifically, the invention provides radiolabel binding moieties that form an electrically neutral complex with technetium-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 25, 2000Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 6086849Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: February 9, 1995Date of Patent: July 11, 2000Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 6074627Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety covalently attached to a specific binding peptide via an amino acid side-chain of the peptide.Type: GrantFiled: May 14, 1996Date of Patent: June 13, 2000Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 6007792Abstract: This invention relates to radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic and radiotherapeutic agents. Specifically, the invention relates to vasoactive intestinal peptide receptor binding peptides, derivatives and analogues of vasoactive intestinal peptide, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to vasoactive intestinal peptide receptor binding peptide derivatives and analogues of vasoactive intestinal peptide radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to vasoactive intestinal peptide receptor binding peptide derivatives and analogues of vasoactive intestinal peptide radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.Type: GrantFiled: January 21, 1998Date of Patent: December 28, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, Daniel A. Pearson, John Lister-James, Edgar R. Civitello
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Patent number: 5997844Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety covalently attached to a specific binding peptide via an amino acid side-chain of the peptide.Type: GrantFiled: June 3, 1994Date of Patent: December 7, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5997845Abstract: This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.Type: GrantFiled: July 29, 1997Date of Patent: December 7, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James, Edgar R. Civitello
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Patent number: 5965107Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: April 20, 1992Date of Patent: October 12, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5922303Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 13, 1999Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5849261Abstract: This invention relates to radiotherapeutic reagents and peptides, radiodiagnostic reagents and peptides, and methods for producing labeled radiodiagnostic and radiotherapeutic agents. Specifically, the invention relates to VIP receptor binding peptides, derivatives and analogues of VIP, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes. The invention specifically relates to VIP receptor binding peptide derivatives and analogues of VIP radiolabeled with technetium-99m and uses thereof as scintigraphic imaging agents. The invention also specifically relates to VIP receptor binding peptide derivatives and analogues of VIP radiolabeled with cytotoxic radioisotopes such as rhenium-186 (.sup.186 Re) and rhenium-188 (.sup.188 Re) for use as radiotherapeutic agents.Type: GrantFiled: March 31, 1995Date of Patent: December 15, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Daniel A. Pearson, John Lister-James, Edgar R. Civitello
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Patent number: 5830856Abstract: This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.Type: GrantFiled: June 3, 1994Date of Patent: November 3, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James, Edgar R. Civitello, William McBride
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Patent number: 5780007Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 14, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5776428Abstract: This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety which forms a neutral complex with Tc-99m.Type: GrantFiled: June 6, 1995Date of Patent: July 7, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5720934Abstract: This invention relates to radiolabel binding moieties for producing radiolabeled peptides and methods for making such peptides. Specifically, the invention relates to picolinic acid or picolinamine containing radiolabel binding moieties, peptides radiolabeled therewith and methods of making and using both the radiolabel binding moieties and peptides radiolabeled therewith.Type: GrantFiled: June 6, 1995Date of Patent: February 24, 1998Assignee: Diatide, Inc.Inventors: Richard T. Dean, Scott Buttram, William McBride, John Lister-James, Edgar R. Civitello
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Patent number: 5645815Abstract: This invention relates to radiolabeled scintigraphic imaging agents, and methods and reagents for producing such agents. Specifically, the invention relates to specific binding compounds, including peptides, that bind to a platelet receptor that is the platelet GPIIb/IIIa receptor, methods and kits for making such compounds, and methods for using such compounds labeled with technetium-99m via a covalently-linked radiolabel-binding moiety to image thrombi in a mammalian body.Type: GrantFiled: May 12, 1995Date of Patent: July 8, 1997Assignee: Diatide, Inc.Inventors: Richard T. Dean, John Lister-James, Edgar R. Civitello