Patents by Inventor Edgars Jecs

Edgars Jecs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240316034
    Abstract: The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.
    Type: Application
    Filed: May 3, 2024
    Publication date: September 26, 2024
    Inventors: Dennis C. Liotta, Edgars Jecs, Robert James Wilson, Huy Hoang Nguyen, Michelle Bora Kim, Lawrence Wilson, Eric Miller, Yesim Altas Tahirovic, Valarie Truax
  • Patent number: 12016863
    Abstract: Disclosed herein are compounds having antiviral activity, and, in particular, an inhibitory activity on the replication of Respiratory Syncytial Virus (RSV). Druggable target sites, including Px, in the RSV N protein are disclosed, as well as compounds targeting Px. The compounds can be used to treat patients with RSV infection.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: June 25, 2024
    Assignees: Georgia State University Research Foundation, Inc., Emory University
    Inventors: Richard Plemper, Julien Sourimant, Edgars Jecs, Dennis Liotta, Stephen Pelly, Robert Wilson, Zackery Will Dentmon
  • Publication number: 20240158368
    Abstract: Pyrrolidine main protease inhibitors are described that are effective as antiviral compounds.
    Type: Application
    Filed: October 12, 2023
    Publication date: May 16, 2024
    Applicant: AbbVie Inc.
    Inventors: David A. Degoey, Michael R. Schrimpf, David J. Hardee, Jacob Ludwig, Eric R. Miller, Timothy R. Hodges, Alberto Munoz, Sarah J. Perlmutter, Huan-Qiu X. Li, Alvin Jang, Elizabeth L. Noey, Gregory A. Gfesser, Edgars Jecs, Robert G. Schmidt, Justin D. Dietrich, Xenia B. Searle, Boguslaw P. Nocek, Andrew Bogdan
  • Publication number: 20230271961
    Abstract: This disclsore relates to compounds according to Formula (I), salts, prodrugs and pharmaceutical formulation comprising the compound are provided herein for the treatment of CXCR4 and CCR5 related conditions. The conditions may include viral infections, abnormal cellular proliferation, retinal degeneration and inflammatory diseases, or the compounds may be used as immunostimulants or immunosuppressants. Furthermore, the compounds may be used in combination with another active ingredient selected from an antiviral agent or chemotherapeutic agent.
    Type: Application
    Filed: April 10, 2023
    Publication date: August 31, 2023
    Inventors: Dennis Liotta, Edgars Jecs, Yesim Altas Tahirovic, Lawrence Wilson, Stephen Pelly
  • Patent number: 11649235
    Abstract: This disclosure relates to compounds according to Formula (I), salts, prodrugs and pharmaceutical formulation comprising the compound are provided herein for the treatment of CXCR4 and CCR5 related conditions. The conditions may include viral infections, abnormal cellular proliferation, retinal degeneration and inflammatory diseases, or the compounds may be used as immunostimulants or immunosuppressants. Furthermore, the compounds may be used in combination with another active ingredient selected from an antiviral agent or chemotherapeutic agent.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: May 16, 2023
    Assignee: Emory University
    Inventors: Dennis Liotta, Edgars Jecs, Yesim Altas Tahirovic, Lawrence Wilson, Stephen Pelly
  • Publication number: 20230112832
    Abstract: The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.
    Type: Application
    Filed: October 25, 2022
    Publication date: April 13, 2023
    Inventors: Dennis C. Liotta, Edgars Jecs, Robert James Wilson, Huy Hoang Nguyen, Michelle Bora Kim, Lawrence Wilson, Eric Miller, Yesim Altas Tahirovic, Valarie Truax, Thomas Kaiser
  • Patent number: 11497744
    Abstract: The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.
    Type: Grant
    Filed: February 21, 2018
    Date of Patent: November 15, 2022
    Assignee: Emory University
    Inventors: Dennis Liotta, Edgars Jecs, Robert James Wilson, Huy Hoang Nguyen, Michelle Bora Kim, Lawrence Wilson, Eric James Miller, Yesim Altas Tahirovic, Valarie Truax
  • Publication number: 20210244740
    Abstract: Disclosed herein are compounds having antiviral activity, and, in particular, an inhibitory activity on the replication of Respiratory Syncytial Virus (RSV). Druggable target sites, including Px, in the RSV N protein are disclosed, as well as compounds targeting Px. The compounds can be used to treat patients with RSV infection.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 12, 2021
    Inventors: Richard PLEMPER, Julien SOURIMANT, Edgars JECS, Dennis LIOTTA, Stephen PELLY, Robert WILSON, Zackery Will DENTMON
  • Publication number: 20210017178
    Abstract: This disclosure relates to compounds according to Formula (I), salts, prodrugs and pharmaceutical formulation comprising the compound are provided herein for the treatment of CXCR4 and CCR5 related conditions. The conditions may include viral infections, abnormal cellular proliferation, retinal degeneration and inflammatory diseases, or the compounds may be used as immunostimulants or immunosuppressants. Furthermore, the compounds may be used in combination with another active ingredient selected from an antiviral agent or chemotherapeutic agent.
    Type: Application
    Filed: March 19, 2019
    Publication date: January 21, 2021
    Inventors: Dennis Liotta, Edgars Jecs, Yesim Altas Tahirovic, Lawrence Wilson, Stephen Pelly
  • Publication number: 20200054623
    Abstract: The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed compounds or pharmaceutically acceptable salts or prodrugs thereof. The compositions may be used for managing CXCR4 related conditions, typically prevention or treatment of viral infections abnormal cellular proliferation, retinal degeneration, inflammatory diseases, or as an immunostimulant or immunosuppressant or for managing cancer and may be administered with another active ingredient such as an antiviral agent or chemotherapeutic agent.
    Type: Application
    Filed: February 21, 2018
    Publication date: February 20, 2020
    Inventors: Dennis Liotta, Edgars Jecs, Robert James Wilson, Huy Hoang Nguyen, Michelle Bora Kim, Lawrence Wilson, Eric James Miller, Yesim Altas Tahirovic, Valarie Truax, Thomas Kaiser