Patents by Inventor Edilio Borroni

Edilio Borroni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radiolabeled compounds
    Patent number: 11541132
    Abstract: The present invention relates to radiolabeled compounds of formula I wherein either A, B, R1, R2, is labeled with a radionuclide selected from 3H, 11C and 18F and its use for imaging alpha synuclein and/or Abeta deposits in mammals.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: January 3, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Martin Edelmann, Dale Mitchell, David Hardick, Wolfgang Schmidt, Christopher Steele, Mushtaq Mulla
  • 2-hetaryl imidazol[1,2-a]pyridine derivatives
    Patent number: 11358962
    Abstract: The invention relates to small molecule imaging tools, specifically compounds of formula II and to pharmaceutically acceptable acid addition salts thereof, wherein R1-R6 have any of the values defined in the specification.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: June 14, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • Imaging methods using 2-hetaryl imidazol[1,2-a]pyridine derivatives
    Patent number: 10975073
    Abstract: The invention relates to small molecule imaging tools.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: April 13, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • RADIOLABELED COMPOUNDS
    Publication number: 20200316232
    Abstract: The present invention relates to radiolabeled compounds of formula I wherein either A, B, R1, R2, is labeled with a radionuclide selected from 3H, C and 18F and its use for imaging alpha synuclein and/or Abeta deposits in mammals.
    Type: Application
    Filed: June 19, 2020
    Publication date: October 8, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Edilio BORRONI, Luca GOBBI, Michael HONER, Martin EDELMANN, Dale MITCHELL, David HARDICK, Wolfgang SCHMIDT, Christopher STEELE, Mushtaq MULLA
  • 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES
    Publication number: 20190048003
    Abstract: The invention relates to small molecule imaging tools.
    Type: Application
    Filed: October 16, 2018
    Publication date: February 14, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES
    Publication number: 20190048002
    Abstract: The invention relates to small molecule imaging tools.
    Type: Application
    Filed: October 16, 2018
    Publication date: February 14, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • 2-phenyl or 2-hetaryl imidazol[1,2-a]pyridine derivatives
    Patent number: 10138234
    Abstract: The invention relates to compounds of formula I: and to pharmaceutically acceptable acid addition salts thereof, wherein R1-R6, Ra, and Rb have any of the values defined in the specification. The compounds are suitable as imaging tools.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: November 27, 2018
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • 2-PHENYL OR 2-HETARYL IMIDAZOL[1,2-a]PYRIDINE DERIVATIVES
    Publication number: 20160244441
    Abstract: The invention relates to compounds of formulas I and II wherein R1 is hydrogen, lower alkyl, lower alkoxy, halogen, S-lower alkyl, lower alkoxy substituted by halogen, di-lower alkyl amino, C(O)O-lower alkyl, lower alkyl substituted by hydroxy or hydroxy; R2 is hydrogen, lower alkyl, halogen, lower alkoxy, S-lower alkyl, lower alkoxy substituted by halogen, O(CH2)2-lower alkoxy substituted by halogen, di-lower alkyl amino, alkyl amino, NH-lower alkyl substituted by halogen, N(lower alkyl)-benzyl, lower alkyl substituted by hydroxy, heterocycloalkyl optionally substituted by halogen, CH2-lower alkoxy, CH2-lower alkoxy substituted by halogen or hydroxy; or R1 and R2 form together with the carbon atoms to which they are attached a ring containing —OCH2CH2O—, OCH2O—, OCH2CH2CH2O— or —NHC(O)CH2O—; R3 is hydrogen or lower alkoxy; R4 is hydrogen or lower alkyl; R5 is lower alkyl, cycloalkyl, lower alkyl substituted by hydroxy or lower alkyl substituted by halogen; or R4 and R5 form together with the nitrogen at
    Type: Application
    Filed: October 28, 2015
    Publication date: August 25, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Edilio Borroni, Luca Gobbi, Michael Honer, Henner Knust, Matthias Koerner, Dieter Muri
  • RADIOLABELED COMPOUNDS
    Publication number: 20160031878
    Abstract: The present invention relates to radiolabeled compounds of formula I wherein R1, R2, R3 and R4 are as defined herein.
    Type: Application
    Filed: July 30, 2015
    Publication date: February 4, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Edilio BORRONI, Alexander FLOHR, Luca GOBBI, Thomas HARTUNG, Raphael HOAREAU, Michael HONER, Laurent MARTARELLO
  • METHOD FOR THE IDENTIFICATION OF BETA-SHEET AGGREGATED PROTEIN LIGANDS
    Publication number: 20140363898
    Abstract: The present invention provides an assay for the identification of beta-sheet aggregated protein ligands using Thiazine Red R.
    Type: Application
    Filed: December 20, 2013
    Publication date: December 11, 2014
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Edilio Borroni, Christian Czech, Arnulf Dorn, Luca Gobbi, Valerie Goetschy-Meyer, Fiona Grueninger, Doris Roth
  • [1,3]OXAZINES
    Publication number: 20140112867
    Abstract: The present invention provides compounds of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes. The invention further provides a radio-labelled derivative thereof.
    Type: Application
    Filed: June 4, 2012
    Publication date: April 24, 2014
    Inventors: Edilio Borroni, Luca Gobbi, Hans Hilpert, Michael Honer, Dieter Muri, Robert Narquizian, Alessandra Polara