Abstract: The presently disclosed subject matter is directed to a system and method of preparing personalized nutritional and/or pharmaceutical formulations using additive manufacturing technology. Active pharmaceutical or dietary supplement ingredients are suspended in thixotropic stable carrier medias. The thixotropic suspensions are deposited onto a surface of a solid substrate, which can be a snack bar or small wafer used as a mechanical carrier. The disclosed system enables each additive active ingredient to be variably dosed based on a formula that is determined for each specific individual and manufactured on demand. Once the active ingredients are deposited on substrate, the entire assembly can be enrobed with one or more edible solid coatings to seal the active ingredients and provide taste-masking agent characteristics to the assembly.

Abstract: The presently disclosed subject matter is directed to a system and method of preparing personalized nutritional and/or pharmaceutical formulations using additive manufacturing technology. Active pharmaceutical or dietary supplement ingredients are suspended in thixotropic stable carrier medias. The thixotropic suspensions are deposited onto a surface of a solid substrate, which can be a snack bar or small wafer used as a mechanical carrier. The disclosed system enables each additive active ingredient to be variably dosed based on a formula that is determined for each specific individual and manufactured on demand. Once the active ingredients are deposited on substrate, the entire assembly can be enrobed with one or more edible solid coatings to seal the active ingredients and provide taste-masking agent characteristics to the assembly.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: The presently disclosed subject matter is directed to a system and method of preparing personalized nutritional and/or pharmaceutical formulations using additive manufacturing technology. Active pharmaceutical or dietary supplement ingredients are suspended in thixotropic stable carrier medias. The thixotropic suspensions are deposited onto a surface of a solid substrate, which can be a snack bar or small wafer used as a mechanical carrier. The disclosed system enables each additive active ingredient to be variably dosed based on a formula that is determined for each specific individual and manufactured on demand. Once the active ingredients are deposited on substrate, the entire assembly can be enrobed with one or more edible solid coatings to seal the active ingredients and provide taste-masking agent characteristics to the assembly.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: The presently disclosed subject matter is directed a system and method of creating personalized doses of active pharmaceutical ingredients (APIs) dispersed in a palatable oral formulation. The APIs are encapsulated into microparticles that are dispersed within a thixotropic suspension vehicle to create a customized oral formulation. The formulation can be customized for a particular subject based on medical condition, time release of the API, release profile of the API, and taste preference of the subject.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: The one or more embodiments disclosed herein provide a method for automatically assembling multiple compounds into a single edible custom composition, in which each compound is individually customized to proportions formulated from a profile of an individual or group. The single custom mixture can contain a plurality of compounds including foods or flavors, nutritional additives, herbals, biologics, or pharmacologically active substances. Using the method and a related algorithm, the formulation of a custom mixture is suggested.

Abstract: A multiple stage buoyancy changing system, or variable buoyancy device, for an underwater vehicle. The multiple stage buoyancy changing system comprises: a pressure hull containing a flexibly-sized internal fluid reservoir; a flexibly-sized external fluid reservoir attached to the pressure hull and connected to the internal reservoir; a system of devices and channels configured to move fluid between the internal fluid reservoir and the external fluid reservoir to change a displaced volume of the vehicle. Each stage of the variable buoyancy device can be optimized for maximum energy efficiency while changing the vehicle's displaced volume within an ambient pressure range. A control system for the variable buoyancy device engages different stages depending on ambient external pressure such that maximum energy efficiency is achieved over a large range of pressures/depths.

Abstract: Multi-stage buoyancy changing system for an autonomous underwater vehicle comprises: an internal reservoir configured to hold a fluid; an external bladder connected to the internal reservoir and configured to exchange fluid with the internal reservoir via one or more channels; a first device configured to move fluid through a channel from the internal reservoir to the external bladder at an optimized efficiency for an ambient pressure of a first segment of a dive profile to increase apparent displacement and buoyancy of the vehicle; and a second device configured to move fluid through a channel from the internal reservoir to the external bladder at an optimized efficiency for an ambient pressure of a second segment of the dive profile to increase an apparent displacement and a buoyancy of the vehicle. The first segment of the dive profile includes a different ambient pressure range than the second segment of the dive profile.

Abstract: An hybrid unmanned underwater vehicle comprises a body housing a controller; a vector thruster for propelling the body; deployable wings allowing the unmanned underwater vehicle to traverse by gliding as the unmanned underwater vehicle ascends and descends; a center-of-mass shifter for shifting a center-of-mass of the vehicle to allow the unmanned underwater vehicle to pitch up and pitch down; and one of a multi-stage buoyancy control system within the body and configured to adjust an apparent displacement of the unmanned underwater vehicle and an expandable outer shell configured to adjust an apparent displacement and therefore a buoyancy of the unmanned underwater vehicle.

Abstract: A multiple stage buoyancy changing system, or variable buoyancy device, for an underwater vehicle. The multiple stage buoyancy changing system comprises: a pressure hull containing a flexibly-sized internal fluid reservoir; a flexibly-sized external fluid reservoir attached to the pressure hull and connected to the internal reservoir; a system of devices and channels configured to move fluid between the internal fluid reservoir and the external fluid reservoir to change a displaced volume of the vehicle. Each stage of the variable buoyancy device can be optimized for maximum energy efficiency while changing the vehicle's displaced volume within an ambient pressure range. A control system for the variable buoyancy device engages different stages depending on ambient external pressure such that maximum energy efficiency is achieved over a large range of pressures/depths.