Patents by Inventor Edith Aberdam

Edith Aberdam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for promoting wound healing in a subject suffering from ectodermal dysplasias
    Patent number: 12521392
    Abstract: The present invention relates to a method for promoting wound healing in a subject suffering from Ectodermal dysplasia in need thereof comprising a step of administering subcutaneously, intradermally or topically to said subject a therapeutically effective amount of a compound which restores the activity of p63. Inventors have performed a primary culture of patient keratinocytes suffering from ectodermal dysplasias with two compounds which restore the activity of p63 (e.g. STIMA-1 and/or PRIMA-1Met). They have shown that there is an important differentiation of the keratinocytes of said patient compared to the cells not treated with these compounds. They observed that the activity of p63 mutated is restored, thus the proliferation and differentiation of keratinocytes from the patient are activated. Moreover, inventors have used PRIMA-1Met by topical application on a young patient suffering from ectodermal dysplasias and shown that said patient presents an improvement on her hand.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: January 13, 2026
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), UNIVERSITÉ DE PARIS, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
    Inventors: Daniel Aberdam, Edith Aberdam, Smail Hadj-Rabia, Salvatore Cisternino
  • METHODS AND COMPOSITIONS FOR PROMOTING WOUND HEALING IN A SUBJECT SUFFERING FROM ECTODERMAL DYSPLASIAS
    Publication number: 20210322418
    Abstract: The present invention relates to a method for promoting wound healing in a subject suffering from Ectodermal dysplasia in need thereof comprising a step of administering subcutaneously, intradermally or topically to said subject a therapeutically effective amount of a compound which restores the activity of p63. Inventors have performed a primary culture of patient keratinocytes suffering from ectodermal dysplasias with two compounds which restore the activity of p63 (e.g. STIMA-1 and/or PRIMA-1Met). They have shown that there is an important differentiation of the keratinocytes of said patient compared to the cells not treated with these compounds. They observed that the activity of p63 mutated is restored, thus the proliferation and differentiation of keratinocytes from the patient are activated. Moreover, inventors have used PRIMA-1Met by topical application on a young patient suffering from ectodermal dysplasias and shown that said patient presents an improvement on her hand.
    Type: Application
    Filed: July 15, 2019
    Publication date: October 21, 2021
    Inventors: Daniel ABERDAM, Edith ABERDAM, Smail HADJ-RABIA, Salvatore CISTERNINO
  • Isolated population of cells and methods of generating and using same
    Patent number: 9085754
    Abstract: An isolated homogeneous population of cells comprising a plurality of human ectodermal progenitor cells. Also provided are methods of generating and using the population of cells.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: July 21, 2015
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Daniel Aberdam, Edith Aberdam, Efrat Barak, Michal Amit, Joseph Itskovitz-Eldor
  • ISOLATED POPULATIONS OF CELLS AND METHODS OF GENERATING AND USING SAME
    Publication number: 20100233136
    Abstract: An isolated homogeneous population of cells comprising a plurality of human ectodermal progenitor cells. Also provided are methods of generating and using the population of cells.
    Type: Application
    Filed: March 27, 2008
    Publication date: September 16, 2010
    Inventors: Daniel Aberdam, Edith Aberdam, Efrat Barak, Michal Amit, Joseph Itskovitz-Eldor