Patents by Inventor Edith C. Wolff

Edith C. Wolff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of diagnosing and treating hyperproliferative disorders
    Publication number: 20180237517
    Abstract: The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.
    Type: Application
    Filed: January 2, 2014
    Publication date: August 23, 2018
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Hartmut M. Hanauske-Abel, Myung-Hee Park, Edith C. Wolff, Debra Sheldon-Heller, Bernadette M. Cracchiolo, Anthony Popowicz, Paul M. Clement
  • Methods of diagnosing and treating hyperproliferative disorders
    Publication number: 20170226201
    Abstract: The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.
    Type: Application
    Filed: January 2, 2014
    Publication date: August 10, 2017
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Hartmut M. Hanauske-Abel, Myung-Hee Park, Edith C. Wolff, Debra Sheldon-Heller, Bernadette M. Cracchiolo, Anthony Popowicz, Paul M. Clement
  • Methods of diagnosing and treating hyperproliferative disorders
    Publication number: 20090253777
    Abstract: The invention relates to compositions and methods for diagnosing and treating hyperproliferative disorders using ligands which specifically recognize the hypusine and/or folate binding region of mature eukaryotic translation initiation factor 5A (hypusine-containing eIF-5A). The invention further relates to methods of identifying molecules which displace immunoreagents binding to mature eIF-5A. Such agents are useful for treating hyperproliferative disorders.
    Type: Application
    Filed: September 13, 2003
    Publication date: October 8, 2009
    Inventors: Hartmut M. Hanauske-Abel, Myung-Hee Park, Edith C. Wolff, Debra Sheldon-Heller, Bernadette M. Cracciolo, Anthony Popowicz, Paul M.J. Clement
  • Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation
    Patent number: 7141589
    Abstract: A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: November 28, 2006
    Assignees: The United States of America as represented by the Department of Health and Human Services, University of Medicine and Dentistry of New Jersey
    Inventors: Myung Hee Park, Paul M Clement, Hartmut M Hanauske-Abel, Edith C. Wolff, Hynda K Kleinman, Bernadette M Cracchiolo
  • Methods of inhibiting formation of vascular channels and methods of inhibiting proliferation
    Publication number: 20040198636
    Abstract: A method of inhibiting formation of vascular channels in tissues and a method of inhibiting proliferation of a cell of a non-vascularized intraepithelial neoplasia, both of which methods comprise administering to the tissues or the cell a compound.
    Type: Application
    Filed: May 11, 2004
    Publication date: October 7, 2004
    Inventors: Myung Hee Park, Paul M. Clement, Hartmut M. Hanauske-Abel, Edith C. Wolff, Hynda K. Kleinman, Bernadette M. Cracchiolo
  • Compositions and methods for inhibiting deoxyhypusine synthase and the growth of cells
    Patent number: 5344846
    Abstract: Compositions and methods for the treatment of mammalian cells to inhibit cell growth, especially for inhibiting the proliferative cell growth associated with malignant and non-malignant disease, are provided. More particularly, a deoxyhypusine synthase inhibitor, typically, a mono- or bisguanyl diamine or polyamine, is administered to the cells.Also provided by this invention are diagnostic methods and kits for screening the cells of a patient to determine the effect of the deoxyhypusine synthase inhibitor on proliferation of the cells.
    Type: Grant
    Filed: December 30, 1992
    Date of Patent: September 6, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Judit Jakus, Myung H. Park, Edith C. Wolff, John E. Folk