Patents by Inventor Edith Chitlaru

Edith Chitlaru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Homogeneity and secretion of recombinant proteins in mammalian systems
    Patent number: 7282352
    Abstract: The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human hGH. Specifically, the present invention relates to a method wherein the protein of interest is a subunit of the follicle stimulating hormone (FSH). The invention also relates to DNA expression vectors containing the sequence encoding such proteins of interest fused to the signal peptide sequence of the hGH and to cells harbouring such vectors.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: October 16, 2007
    Assignee: Applied Research Systems ARS Holding N.V.
    Inventors: Edith Chitlaru, Hagit Amitai, Daniel Helman
  • Expression and secretion of icIL-1 receptor antagonist type II
    Publication number: 20060293230
    Abstract: Novel glycosylated intracellular IL-1 receptor antagonist type II (icIL-1ra-II) is expressed and secreted in mammalian cells transformed with an expression vector where icIL-1ra-II is secreted by expressing icIL-1ra-II fused to the human growth hormone signal peptide. Also disclosed are a pharmaceutical composition containing glycosylated icIL-1ra-Il as an active ingredient and a method for reducing IL-1 levels in patients having a condition involving overexpressed IL-1.
    Type: Application
    Filed: July 29, 2005
    Publication date: December 28, 2006
    Applicant: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
    Inventors: Hagit Amitai, Edith Chitlaru
  • Homogeneity and secretion of recombinant proteins in mammalian systems
    Publication number: 20060234352
    Abstract: The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human hGH. Specifically, the present invention relates to a method wherein the protein of interest is a subunit of the follicle stimulating hormone (FSH). The invention also relates to DNA expression vectors containing the sequence encoding such proteins of interest fused to the signal peptide sequence of the hGH and to cells harbouring such vectors.
    Type: Application
    Filed: June 2, 2004
    Publication date: October 19, 2006
    Applicant: Applied Research Systems ARS Holding N.V.
    Inventors: Edith Chitlaru, Hagit Amitai, Daniel Helman
  • Homogeneity and secretion of recombinant proteins in mammalian systems
    Publication number: 20040115775
    Abstract: The present invention relates to a method for improving homogeneity and/or secretion of a recombinant protein of interest expressed in mammalian cells by replacing the endogenous signal peptide sequence of the DNA encoding the protein of interest with that of human hGH. The invention also relates to DNA expression vectors containing the sequence encoding such proteins fused to the signal peptide sequence of the hGH and to cells harboring such vectors.
    Type: Application
    Filed: November 26, 2003
    Publication date: June 17, 2004
    Inventors: Edith Chitlaru, Hagit Amitai
  • Bacterial catabolism of chitin
    Patent number: 5985644
    Abstract: Three genes involved in the catabolism of chitin in Vibrio furnissii: endI encodes periplasmic chitodextrinase, exoI encodes periplasmic .beta.-N-acetylglucosaminidase, and exoII encodes aryl .beta.-N-acetylglucosaminidase are provided. The complete nucleotide sequence for each of the three genes and the complete amino acid for the corresponding enzymes are demonstrated along with host cells capable of expressing the recombinant enzymes. The present invention also describes four specific strains of V. furnissii having deletions in genes involved in the catabolic pathway of chitin and a process for the production of chitin oligosaccharides.
    Type: Grant
    Filed: February 13, 1996
    Date of Patent: November 16, 1999
    Assignee: The Johns Hopkins University
    Inventors: Saul Roseman, Bonnie Bassler, Nemat O. Keyhani, Edith Chitlaru, Charles Yu
  • Bacterial catabolism of chitin
    Patent number: 5792647
    Abstract: The present invention reveals the cloning of four genes involved in the catabolism of chitin in Vibrio furnissii: endI encodes periplasmic chitodextrinase, exoI encodes periplasmic .beta.-N-acetylglucosaminidase, exoII encodes aryl .beta.-N-acetyl-glucosaminidase and chiA encodes extracellular chitinase. The complete nucleotide sequence for each of the four genes and the complete amino acid for the corresponding enzymes are demonstrated along with host cells capable of expressing the recombinant enzymes. The present invention also describes four specific strains of V. furnissii having deletions in genes involved in the catabolic pathway of chitin and a process for the production of chitin oligosaccharides.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: August 11, 1998
    Assignee: The Johns Hopkins University
    Inventors: Saul Roseman, Bonnie Bassler, Nemat O. Keyhani, Edith Chitlaru, Chris Rowe, Charles Yu