Patents by Inventor Edith M. Lord

Edith M. Lord has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human glandular kallikrein (hk2)-specific monoclonal antibodies that enhance or inhibit the enzymatic activity of hk2
    Publication number: 20040219163
    Abstract: Disclosed are compositions and methods for preferentially binding hK2 over PSA.
    Type: Application
    Filed: May 27, 2004
    Publication date: November 4, 2004
    Inventors: John G. Frelinger, Terrence L. Fisher, Mary Ann Nocera, Edith M. Lord
  • Detection of hypoxia
    Patent number: 5843404
    Abstract: Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.
    Type: Grant
    Filed: February 8, 1996
    Date of Patent: December 1, 1998
    Assignees: Trustees of the University of Pennsylvania, Trustees of the University of Rochester
    Inventors: Cameron J. Koch, Edith M. Lord
  • Method of monitoring exposure to Bowman Birk inhibitor using monoclonal antibodies against Bowman Birk inhibitor metabolites
    Patent number: 5618679
    Abstract: Monoclonal antibodies and a method capable of detecting Bowman Birk inhibitor metabolites in a sample of body fluid or tissue are provided.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: April 8, 1997
    Assignees: Trustees of the University of Pennsylvania, University of Rochester
    Inventors: Ann R. Kennedy, Cameron J. Koch, Edith M. Lord, Xingsheng Wan
  • Monoclonal antibodies differentially reactive with native and reductively modified Bowman-Birk protease inhibitor
    Patent number: 5616492
    Abstract: Monoclonal antibodies and a method capable of detecting BBI metabolites in a sample of body fluid or tissue are provided.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: April 1, 1997
    Assignees: Trustees of the University of Pennsylvania, University of Rochester
    Inventors: Ann R. Kennedy, Cameron J. Koch, Edith M. Lord, Xingsheng Wan
  • Detection of hypoxia with reagents containing 2-nitroimidazole compounds and methods of making such reagents
    Patent number: 5540908
    Abstract: Novel nitroaromatic compounds and immunogenic conjugates comprising a novel nitroaromatic compound and a carrier protein are disclosed. The invention further presents monoclonal antibodies highly specific for the claimed nitroaromatic compounds, the compounds' protein conjugates, the compounds' reductive byproducts, and adducts formed between the compounds and mammalian hypoxic cell tissue proteins. The invention is further directed to methods for detecting tissue hypoxia using immunohistological techniques, non-invasive nuclear medicinal methods, or nuclear magnetic resonance. Diagnostic kits useful in practicing the methods of claimed invention are also provided.
    Type: Grant
    Filed: August 4, 1994
    Date of Patent: July 30, 1996
    Assignees: The Trustees of the Univ. of Pennsylvania, The University of Rochester
    Inventors: Cameron J. Koch, Edith M. Lord
  • Serum free cell culture medium
    Patent number: 4816401
    Abstract: A serum free cell culture medium containing less than 10 ug/ml protein is disclosed. The medium comprises a basal media supplemented with levels of 2-aminoethanol substantially higher than previously disclosed and supplemented with 2-mercaptoethanol, transferrin, insulin and free essential amino acids. Unlike other serum free media, the media disclosed herein will support the growth and long term culture of a large variety of cell types including hybridomas and tumor cell lines while maintaining both growth potential and the differentiated characteristics of the particular cell line.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: March 28, 1989
    Assignee: University of Rochester
    Inventors: Mary A. Taupier, Edith M. Lord