Patents by Inventor Edith Mathiowitz
Edith Mathiowitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170157083Abstract: Formulations of a neuroprotective agent for parenteral administration are described herein. The formulation is in the form of a concentrated (supersaturated) solution or a concentrated suspension of microparticles. The suspension medium or the solution solvent carrier may also contain dissolved neuroprotective agent. For the supersaturated solutions, the agent is dissolved a high concentrations of at least about 1% by weight, 5% by weight, 10% by weight, 15% by weight, or 20% by weight in a solvent suitable for parenteral administration. For the concentrated suspension, the microparticles have an effective particle size form about 100 nm to about 5 microns, preferably form about 50 nm to about 3 microns, more preferably from about 10 nm to about 2 microns. The formulations described herein can be used to treat a variety of neurological disease/disorders and/or neurological injury or trauma.Type: ApplicationFiled: February 21, 2017Publication date: June 8, 2017Inventors: Sasha H. Bakhru, Bryan E. Laulicht, Edith Mathiowitz, Solomon S. Steiner
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Patent number: 9610229Abstract: Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.Type: GrantFiled: January 9, 2015Date of Patent: April 4, 2017Assignee: Chamber Works, LLCInventors: Patrick Duffy, Ellen Dias Jorgensen, Erich Boger, Edith Mathiowitz
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Patent number: 9587213Abstract: Molds for making cell aggregation devices include upper and lower surfaces. Methods of aggregating cells include depositing cells on in a seeding chamber, incubating the cells and removing aggregated cells. Devices for encapsulating aggregates of cells include biocompatible, bio-sustainable substrates compartments and a coating of a biocompatible, bio-sustainable polymer that completely surrounds the substrate and cell-encapsulating compartments.Type: GrantFiled: January 24, 2013Date of Patent: March 7, 2017Assignee: Brown UniversityInventors: Jeffrey Morgan, Peter Chai, Anthony Napolitano, Edith Mathiowitz, Dylan Dean
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Publication number: 20170056396Abstract: Novel anticoagulant reversal compounds are disclosed, as well as methods of making the compounds, pharmaceutical compositions including the compounds, methods of using the compounds to reverse the anticoagulant effects of coagulation inhibitors, and diagnostic assays comprising the compounds.Type: ApplicationFiled: November 10, 2016Publication date: March 2, 2017Inventors: Solomon S. Steiner, Bryan E. Laulicht, Sasha H. Bakhru, Edith Mathiowitz
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Publication number: 20170035847Abstract: Compositions and methods for treating inflammatory disorders of the GI tract are provided. The compositions include a therapeutically effective amount of TGF? and ATRA (all-trans retinoic acid), in a pharmaceutically acceptable carrier suitable for oral administration. TGF? and ATRA are preferably encapsulated in microspheres. The compositions are useful in alleviating symptoms in subject with an inflammatory disease of the gastrointestinal tract. Exemplary subjects include subjects with Chrohns disease, ulcerative colitis, gastritis, irritable bowel syndrome, ileitis, etc. The composition is administered to the subject following a therapeutically effective regimen, for length of time resulting in an improvement in one or more symptoms associated with inflammatory disorders of the GI tract.Type: ApplicationFiled: August 8, 2016Publication date: February 9, 2017Inventors: Nejat K. Egilmez, Edith Mathiowitz, Dominik L. Auci
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Publication number: 20170007513Abstract: Compositions for delivering materials having personal significance to an individual are described herein. The compositions include particles encapsulating a personalizing substance, which can be any material of personal significance. The particles are made from a biocompatible, inert material, preferably a metal. In some embodiments, the composition includes the personalizing particles in a pharmaceutically acceptable carrier for delivery into the skin. A method for delivering materials of personal significance to an individual are also described. The method includes administering particles containing personalizing substances to the recipient. The material is preferably delivered to the individual's skin. Kits for obtaining a personalizing substance from an end user and kits for delivering the encapsulated personalizing substance to the end user are provided. The kits include equipment for obtaining a sample of the personalizing substance and a vial, or personalizing particles.Type: ApplicationFiled: July 11, 2016Publication date: January 12, 2017Inventors: Patrick Duffy, SR., Patrick Duffy, JR., Sherry Freebery, Brian McVeigh, Edith Mathiowitz
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Patent number: 9539187Abstract: Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.Type: GrantFiled: February 5, 2016Date of Patent: January 10, 2017Assignee: Chamber Works, LLCInventors: Patrick Duffy, Ellen Dias Jorgensen, Erich Boger, Edith Mathiowitz
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Patent number: 9539186Abstract: Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.Type: GrantFiled: February 5, 2016Date of Patent: January 10, 2017Assignee: Chamber Works, LLCInventors: Patrick Duffy, Ellen Dias Jorgensen, Erich Boger, Edith Mathiowitz
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Patent number: 9522892Abstract: Novel anticoagulant reversal compounds are disclosed, as well as methods of making the compounds, pharmaceutical compositions including the compounds, methods of using the compounds to reverse the anticoagulant effects of coagulation inhibitors, and diagnostic assays comprising the compounds.Type: GrantFiled: November 29, 2012Date of Patent: December 20, 2016Assignee: PEROSPHERE INC.Inventors: Solomon S. Steiner, Bryan E. Laulicht, Sasha H. Bakhru, Edith Mathiowitz
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Publication number: 20160158120Abstract: Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.Type: ApplicationFiled: February 5, 2016Publication date: June 9, 2016Applicant: Chamber Works, LLCInventors: Patrick Duffy, Ellen Dias Jorgensen, Erich Boger, Edith Mathiowitz
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Publication number: 20160158119Abstract: Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.Type: ApplicationFiled: February 5, 2016Publication date: June 9, 2016Applicant: Chamber Works, LLCInventors: Patrick Duffy, Ellen Dias Jorgensen, Erich Boger, Edith Mathiowitz
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Patent number: 9238011Abstract: Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various embodiments, the therapeutic agent includes at least one selected from the group of: a drug, a protein, a sugar, a carbohydrate, and a nucleotide sequence. In related embodiments, the composition is a fiber, a suture, a sphere, an implant, or a scaffold.Type: GrantFiled: March 15, 2013Date of Patent: January 19, 2016Assignee: Brown UniversityInventors: Edith Mathiowitz, Danya Lavin, Richard Hopkins
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Publication number: 20150320158Abstract: The present invention relates to jewelry or a metal composition containing an additive or personalizing substance such as a nucleic acid, sand or other suitable component intended to have personal significance to the wearer. A nucleic acid personalizing substance may comprise human DNA of amplified repeat sequences. The jewelry may be made by using a cold or warm metallurgical technique. Prior to being integrated into the article of jewelry, the additive may be encapsulated to provide a protective layer around the personalizing substance. The protective layer can prevent degradation of the personalizing substance during manufacture of the article of jewelry. The personalizing substance can also be added to a polymer solution which is cast to form a continuous matrix of polymer including the personalizing substance.Type: ApplicationFiled: March 13, 2015Publication date: November 12, 2015Inventors: Patrick Joseph Duffy, JR., Ellen Dias Jorgensen, Edith Mathiowitz, Christopher Bagnall
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Patent number: 9165703Abstract: An effective method for prolonging localization of therapeutics within the rat gastrointestinal tract of at least about 12 hours is provided. The method includes localization of therapeutic agents that are nanoparticulated or nanoencapsulated. Attractive forces between an orally administered magnetic dose and an external magnet were monitored and internal dose motion in real time using biplanar videofluoroscopy was visualized. Tissue elasticity was quantified as a measure of tissue health by combining data streams. The methods address safety, efficacy, and monitoring capacity of magnetically localized doses and show a platform for testing the benefits of localized drug delivery.Type: GrantFiled: December 21, 2011Date of Patent: October 20, 2015Assignee: BROWN UNIVERSITYInventors: Bryan Laulicht, Edith Mathiowitz
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Publication number: 20150216935Abstract: Compositions and methods for producing autologous brown adipose cells in vitro or in vivo are provided. In particular, a drug delivery device is described that recruits adipose stem cells (ASCs) to a site in the body of a subject. These ASCs may then be isolated and induced to differentiate into autologous brown adipose cells. Alternatively, the drug delivery device may also include differentiation factors that induce differentiation of the recruited ASCs into brown adipose cells in vivo. The brown adipose cells produced by these methods may be used therapeutically to treat conditions, such as obesity and diabetes.Type: ApplicationFiled: August 8, 2013Publication date: August 6, 2015Applicant: Brown UniversityInventors: Edith Mathiowitz, Sasha Bakhru
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Publication number: 20150196478Abstract: Compositions for delivering materials, such as a biological material, sand, soil, metal, water, sea water, holy water, synthetic or biological polymers, cremated ash, ceramics, animal or plant tissue, or another physiologically compatible component having personal significance to an individual are described herein. The material(s) are encapsulated in an inert, non-bioerodible, hydrophobic, polymeric material. Methods of making microparticles encapsulating the personalizing substance and methods of use are also provided. The personalizing substance may be encapsulated in a polymeric non-bioerodible microparticle. The encapsulated personalizing substance may be combined with a carrier for delivery to an individual's skin. In some embodiments, the personalizing substance is added to a tattoo ink and incorporated in a tattoo created on an individual's skin. Following injection in the skin, the encapsulated material remains in the microparticles, and is not released over time.Type: ApplicationFiled: January 9, 2015Publication date: July 16, 2015Applicant: CHAMBER WORKS, LLCInventors: PATRICK DUFFY, ELLEN DIAS JORGENSEN, ERICH BOGER, EDITH MATHIOWITZ
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Publication number: 20140271931Abstract: Topical formulations containing one or more pharmaceutically acceptable bioadhesive film-forming agent, one or more anti-acne agent, and an aqueous solvent in the form of a solution or suspension are described herein. The formulation may further contain one or more excipients, including evaporation suppressants, humectants, or plasticizers. When the formulation is contacted with the skin of a patient, the solvent evaporates and forms a thin, transparent, and solid bioadhesive film. The bioadhesive film adheres to the skin surface for a prolonged period of time and the anti-acne agent is released into the skin over a prolonged period of time. Typically, the bioadhesive film adheres to the skin for at least 60 minutes following administration of the formulation, preferably for at least 8 hours following administration, more preferably up to 24 hours following administration. The prolonged retention of the anti-acne agent at the site increases the amount of uptake into the skin.Type: ApplicationFiled: March 12, 2014Publication date: September 18, 2014Applicant: Perosphere Inc.Inventors: Edith Mathiowitz, Bryan E. Laulicht, Sasha H. Bakhru, Solomon S. Steiner
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Publication number: 20140207105Abstract: Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed. Rapid desensitization is achieved by introducing small quantities of antigen into the lymphatic system. In preferred embodiments, the compositions are administered to yield therapeutically effective levels of antigen within the lymph, where macrophages reside in the greatest concentration, by intradermal administration, using for example, microneedles or microparticles, oral administration, using for example, enteric coated capsules or tablets, or autologous transfusion. In some embodiments, the methods and compositions for delivering antigens orally achieve uptake by the Peyer's patches of the small intestines.Type: ApplicationFiled: August 30, 2012Publication date: July 24, 2014Applicant: PEROSPHERE, INC.Inventors: Bryan E. Laulicht, Sasha H. Bakhru, Solomon S. Steiner, Edith Mathiowitz
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Patent number: 8776802Abstract: An effective method for prolonging localization of therapeutics within the rat gastrointestinal tract of at least about 12 hours is provided. Attractive forces between an orally administered magnetic dose and an external magnet were monitored and internal dose motion in real time using biplanar videofluoroscopy was visualized. Tissue elasticity was quantified as a measure of tissue health by combining data streams. The methods address safety, efficacy, and monitoring capacity of magnetically localized doses and show a platform for testing the benefits of localized drug delivery.Type: GrantFiled: August 25, 2011Date of Patent: July 15, 2014Assignee: Brown UniversityInventors: Edith Mathiowitz, Bryan Laulicht
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Publication number: 20140178479Abstract: Formulations of a neuroprotective agent for parenteral administration are described herein. The formulation is in the form of a concentrated (supersaturated) solution or a concentrated suspension of microparticles. The suspension medium or the solution solvent carrier may also contain dissolved neuroprotective agent. For the supersaturated solutions, the agent is dissolved at high concentrations of at least about 1% by weight, 5% by weight, 10% by weight, 15% by weight, or 20% by weight in a solvent suitable for parenteral administration. For the concentrated suspension, the microparticles have an effective particle size from about 100 nm to about 5 microns, preferably from about 50 nm to about 3 microns, more preferably from about 10 nm to about 2 microns. The formulations described herein can be used to treat a variety of neurological diseases/disorders and/or neurological injury or trauma.Type: ApplicationFiled: April 9, 2012Publication date: June 26, 2014Applicant: PEROSPHERE, INC.Inventors: Sasha H. Bakhru, Bryan E. Laulicht, Edith Mathiowitz, Solomon S. Steiner