Abstract: A continuous renal replacement therapy (CRRT) device is provided that weighs between 2 and 10 pounds. The CRRT device can be portable, mobile or completely worn on the person of the patient. Blood and dialysate are each pumped in a pulsed or pulsatile manner through a dialyzer such that a significant portion of the peak pulse of the blood flow coincides with a significant portion of a low pulse portion of the dialysate flow. An differential pressure between a dialysate inlet of the dialyzer and the blood inlet of the dialyzer periodically changes from a high differential pressure of between 70 and 120 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a second time period. The frequency of the high and low differential pressure cycle is between about 0.5 and 4 Hz.

Abstract: A continuous renal replacement therapy (CRRT) device is provided that weighs between 2 and 10 pounds. The CRRT device can be portable, mobile or completely worn on the person of the patient. Blood and dialysate are each pumped in a pulsed or pulsatile manner through a dialyzer such that a significant portion of the peak pulse of the blood flow coincides with a significant portion of a low pulse portion of the dialysate flow. An differential pressure between a dialysate inlet of the dialyzer and the blood inlet of the dialyzer periodically changes from a high differential pressure of between 70 and 120 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a second time period. The frequency of the high and low differential pressure cycle is between about 0.5 and 4 Hz.

Abstract: A continuous renal replacement therapy (CRRT) device is provided that weighs between 2 and 10 pounds. The CRRT device can be portable, mobile or completely worn on the person of the patient. Blood and dialysate are each pumped in a pulsed or pulsatile manner through a dialyzer such that a significant portion of the peak pulse of the blood flow coincides with a significant portion of a low pulse portion of the dialysate flow. An differential pressure between a dialysate inlet of the dialyzer and the blood inlet of the dialyzer periodically changes from a high differential pressure of between 70 and 120 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a second time period. The frequency of the high and low differential pressure cycle is between about 0.5 and 4 Hz.

Abstract: This invention relates to diagnostic and screening medical ultrasound in general and to ultrasound-stimulated detection and location, Image-based Dynamic Ultrasound Spectrography, Acoustic Radiation Force Imaging, and similar modalities in particular. In this invention, an ultrasound signal is emitted into tissue and the resulting radiation force induces localized lower frequency oscillations, which are then received by various acoustic sensors and analyzed to determine certain features or characteristics of the interrogated region. The sensors can be arranged in the form of a ring, in any random arrangements, or positioned in specifically chosen locations. An ultrasonic imaging and excitation transducer generates certain stimulating signals which are received by the breast tissues and which, if they contact a microcalcification, other target, or any region with sharply different mechanical and visco-elastic properties, will result in reflected, demodulated, or re-radiated signals.

Abstract: A method for the detection and localization of breast microcalcification through a precise method of ultrasound impacting and ultrasound frequency wave detection which will enable the system to detect not only if there is a microcalcification in the breast, but the precise location of the microcalcification and the mass of the microcalcification. The invention is also a method and system that provides bi-modal guided stimulation of a targeted mass within the breast to determine the location and nature of the microcalcification within the breast.

Abstract: The present invention is a method for detecting and locating a target using phase information obtained from an array of microphones or other sensors.

Abstract: An ultrafiltration device adapted to be worn on a portion of the body of a patient includes a blood inlet tube leading from a first blood vessel, a blood pump, an anticoagulant reservoir for infusing anticoagulants into the blood, a blood filter including a substrate through which the blood is circulated and filtered, a fluid bag for storing the excess fluid and a blood outlet tube leading to a second blood vessel.

Abstract: Using Image-based Dynamic Ultrasound Spectrography (IDUS®) technology, the intrabody monitoring and positioning of an inserted catheter is achieved by coupling a thin micron-size polymeric wire to the catheter with 100-500 micron metallic cylinder attached to the tip of the wire. The area of interest is imaged and subsequently stimulated using specialized stimulation schemes delivered by an imaging ultrasound transducer. The targeted metallic tip is stimulated and emanates a unique acoustic response (signature) corresponding to its mechanical and material properties. Because of the fundamental structural differences between the targeted metallic tip and its surroundings, its unique resonant frequency signature can be analyzed and differentiated relative to the surrounding soft tissue, the wire and the catheter itself so that the location of the catheter in the body can be determined.

Abstract: An ultrafiltration device adapted to be worn on a portion of the body of a patient includes a blood inlet tube leading from a first blood vessel, a blood pump, an anticoagulant reservoir for infusing anticoagulants into the blood, a blood filter including a substrate through which the blood is circulated and filtered, a fluid bag for storing the excess fluid and a blood outlet tube leading to a second blood vessel.

Abstract: A method for detecting a target or targets in a medium. The method incorporates generating beams of ultrasonic wave energy each having a modulation envelope and causing each beam of wave energy to impact a target region having a multiplicity of targets and demodulating each signal generated by vibration of each target caused by the interaction of a respective ultrasound wave energy beam having a modulation envelope with each of the targets and receiving each demodulated signal from each target by a multiplicity of sensors. Thereafter, each time-of-flight of each demodulated signal from each of the targets to each of the multiplicity of sensors is computed to determine the location of a respective target.

Abstract: The present invention is a non-invasive method and apparatus to determine the structural integrity of an implanted BSCC by insonifying the implanted heart valve with a megahertz frequency to cause the structural components of the heart valve to vibrate at a kilohertz frequency range to cause the individual structural components of the heart valve being investigated to vibrate at their resonant frequency. From experimental testing, the Applicants have established resonant frequency ranges of certain structural components of the BSCC which indicate that at certain resonant frequency ranges the heart valve components are intact. At other resonant frequency ranges, certain components are in danger of breaking. At other frequency ranges, the components of the heart valve are fractured. Through the present invention, the condition of the BSCC can be determined in order to provide a clinical determination as to whether or not the implanted BSCC needs to be replaced.

Abstract: Real-time Ultrasound Burst Spectrography (RUBS) is a technique in which a target is stimulated using a specialized ultrasound burst signal delivered by an imaging or non-imaging ultrasound transducer and the frequency spectrum of the resulting response is analyzed and studied. The objective of this method is to interrogate (vibrate) the target and then examine its characteristic response frequency (resonance) peaks, which are unique to its mechanical and material properties (viscosity, elasticity, plasticity, visco-elasticity, etc.). The resonances could deviate from a few Hz to several KHz and the response could be in the form of a narrow peak or a band of frequencies based on the stiffness coefficient of the target material. The primary goal is to develop a reliable and non-invasive ultrasound-based diagnostic device that can be used to identify different diseases or structural abnormalities based on the stationary or dynamic target's response frequency (resonance) to a specialized acoustic excitation.

Abstract: A dual channel pulsatile pump for use with a completely wearable renal replacement device is provided.

Abstract: A continuous renal replacement therapy (CRRT) device is provided that weighs between 2 and 10 pounds. The CRRT device can be portable, mobile or completely worn on the person of the patient. Blood and dialysate are each pumped in a pulsed or pulsatile manner through a dialyzer such that a significant portion of the peak pulse of the blood flow coincides with a significant portion of a low pulse portion of the dialysate flow. An differential pressure between a dialysate inlet of the dialyzer and the blood inlet of the dialyzer periodically changes from a high differential pressure of between 70 and 120 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a second time period. The frequency of the high and low differential pressure cycle is between about 0.5 and 4 Hz.

Abstract: A continuous renal replacement therapy (CRRT) device adapted to be worn on a portion of the body of a patient. The CRRT device is worn by the patient and operates on rechargeable batteries for more than 5 hours. Dialysate is used to remove impurities from the blood. The dialysate is recycled and refreshed by a filter section. Less than one liter of dialysate is required to circulate through the wearable CRRT device.

Abstract: An ultrafiltration device adapted to be worn on a portion of the body of a patient includes a blood inlet tube leading from a first blood vessel, a blood pump, an anticoagulant reservoir for infusing anticoagulants into the blood, a blood filter including a substrate through which the blood is circulated and filtered, a fluid bag for storing the excess fluid and a blood outlet tube leading to a second blood vessel.

Abstract: A continuous renal replacement therapy (CRRT) device adapted to be worn on a portion of the body of a patient. The CRRT device is worn by the patient and operates on rechargeable batteries for more than 5 hours. Dialysate is used to remove impurities from the blood. The dialysate is recycled and refreshed by a filter section. Less than one liter of dialysate is required to circulate through the wearable CRRT device.

Abstract: A continuous renal replacement therapy (CRRT) device is provided that weighs between 2 and 10 pounds. The CRRT device can be portable, mobile or completely worn on the person of the patient. Blood and dialysate are each pumped in a pulsed or pulsatile manner through a dialyzer such that a significant portion of the peak pulse of the blood flow coincides with a significant portion of a low pulse portion of the dialysate flow. An differential pressure between a dialysate inlet of the dialyzer and the blood inlet of the dialyzer periodically changes from a high differential pressure of between 70 and 120 mmHg for a first time period and a low differential pressure of between ?10 and 10 mmHg for a second time period. The frequency of the high and low differential pressure cycle is between about 0.5 and 4 Hz.

Abstract: A dual channel pulsatile pump for use with a completely wearable renal replacement device is provided.

Abstract: An ultrafiltration device adapted to be worn on a portion of the body of a patient includes a blood inlet tube leading from a first blood vessel, a blood pump, an anticoagulant reservoir for infusing anticoagulants into the blood, a blood filter including a substrate through which the blood is circulated and filtered, a fluid bag for storing the excess fluid and a blood outlet tube leading to a second blood vessel.